SG11201609259VA - Boron-containing proteasome inhibitors for use after primary cancer therapy - Google Patents

Boron-containing proteasome inhibitors for use after primary cancer therapy

Info

Publication number
SG11201609259VA
SG11201609259VA SG11201609259VA SG11201609259VA SG11201609259VA SG 11201609259V A SG11201609259V A SG 11201609259VA SG 11201609259V A SG11201609259V A SG 11201609259VA SG 11201609259V A SG11201609259V A SG 11201609259VA SG 11201609259V A SG11201609259V A SG 11201609259VA
Authority
SG
Singapore
Prior art keywords
boron
cancer therapy
proteasome inhibitors
primary cancer
containing proteasome
Prior art date
Application number
SG11201609259VA
Inventor
Ai-Min Hui
Richard Labotka
Neeraj Gupta
Karthik Venkatakrishnan
Guohui Lui
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of SG11201609259VA publication Critical patent/SG11201609259VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
SG11201609259VA 2014-05-20 2015-05-19 Boron-containing proteasome inhibitors for use after primary cancer therapy SG11201609259VA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462000991P 2014-05-20 2014-05-20
US201462019600P 2014-07-01 2014-07-01
US201462088154P 2014-12-05 2014-12-05
PCT/US2015/031633 WO2015179443A1 (en) 2014-05-20 2015-05-19 Boron-containing proteasome inhibitors for use after primary cancer therapy

Publications (1)

Publication Number Publication Date
SG11201609259VA true SG11201609259VA (en) 2016-12-29

Family

ID=54554652

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201609259VA SG11201609259VA (en) 2014-05-20 2015-05-19 Boron-containing proteasome inhibitors for use after primary cancer therapy
SG10202003693RA SG10202003693RA (en) 2014-05-20 2015-05-19 Boron-containing proteasome inhibitors for use after primary cancer therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202003693RA SG10202003693RA (en) 2014-05-20 2015-05-19 Boron-containing proteasome inhibitors for use after primary cancer therapy

Country Status (22)

Country Link
US (5) US20150335668A1 (en)
EP (1) EP3145526A1 (en)
JP (2) JP2017524652A (en)
KR (2) KR102509950B1 (en)
CN (1) CN106659761A (en)
AU (2) AU2015264272A1 (en)
BR (1) BR112016026774A8 (en)
CA (1) CA2949517A1 (en)
CL (1) CL2016002948A1 (en)
CR (1) CR20160577A (en)
EA (1) EA201692332A1 (en)
IL (2) IL249025B (en)
MA (1) MA39964A (en)
MX (2) MX2016015267A (en)
NZ (1) NZ725948A (en)
PH (1) PH12016502301A1 (en)
SG (2) SG11201609259VA (en)
TN (1) TN2016000492A1 (en)
TW (1) TWI746422B (en)
UA (1) UA121389C2 (en)
UY (1) UY36132A (en)
WO (1) WO2015179443A1 (en)

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CN108472304A (en) * 2015-11-04 2018-08-31 千年药物公司 Method for identifying, evaluating and treating the patient for suffering from Huppert's disease
MA45862A (en) * 2016-08-04 2021-05-05 Millennium Pharm Inc COMBINATION OF PROTEASOME INHIBITORS AND ANTI-CD30 ANTIBODIES
AU2017386771A1 (en) * 2016-12-28 2019-06-20 Daiichi Sankyo Company, Limited Therapeutic drug for Alport's syndrome
US11414437B2 (en) 2017-07-28 2022-08-16 Chengdu Origin Biotechnology Limited Company Borate compound, and synthesis method therefor and uses thereof
TW202342060A (en) * 2021-12-06 2023-11-01 美商普萊萃歐治療公司 Lonp1 inhibitor compounds, uses and methods

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Also Published As

Publication number Publication date
BR112016026774A8 (en) 2021-07-13
US11241448B2 (en) 2022-02-08
IL249025B (en) 2020-05-31
TW201613570A (en) 2016-04-16
PH12016502301A1 (en) 2017-02-13
MX2016015267A (en) 2017-02-22
JP2017524652A (en) 2017-08-31
KR20220097553A (en) 2022-07-07
AU2015264272A1 (en) 2016-11-24
SG10202003693RA (en) 2020-05-28
TN2016000492A1 (en) 2018-04-04
CA2949517A1 (en) 2015-11-26
TWI746422B (en) 2021-11-21
CR20160577A (en) 2017-01-06
EP3145526A1 (en) 2017-03-29
IL274042A (en) 2020-06-30
KR102481856B1 (en) 2022-12-26
NZ725948A (en) 2024-01-26
CL2016002948A1 (en) 2017-03-31
UY36132A (en) 2015-11-30
CN106659761A (en) 2017-05-10
US20150335668A1 (en) 2015-11-26
AU2021200370B2 (en) 2022-11-03
MX2021009044A (en) 2021-09-21
EA201692332A1 (en) 2017-04-28
US20200171061A1 (en) 2020-06-04
WO2015179443A1 (en) 2015-11-26
KR20170005042A (en) 2017-01-11
BR112016026774A2 (en) 2017-08-15
JP6906564B2 (en) 2021-07-21
UA121389C2 (en) 2020-05-25
MA39964A (en) 2015-11-26
KR102509950B1 (en) 2023-03-14
US20210177871A1 (en) 2021-06-17
US20190125773A1 (en) 2019-05-02
US20190343851A1 (en) 2019-11-14
IL249025A0 (en) 2017-01-31
JP2019147837A (en) 2019-09-05
AU2021200370A1 (en) 2021-03-18

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