PE20080143A1 - Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicina - Google Patents
Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicinaInfo
- Publication number
- PE20080143A1 PE20080143A1 PE2007000281A PE2007000281A PE20080143A1 PE 20080143 A1 PE20080143 A1 PE 20080143A1 PE 2007000281 A PE2007000281 A PE 2007000281A PE 2007000281 A PE2007000281 A PE 2007000281A PE 20080143 A1 PE20080143 A1 PE 20080143A1
- Authority
- PE
- Peru
- Prior art keywords
- diazaespiro
- oxo
- dec
- phenyl
- acetamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS 2-OXO-3-FENIL-(1,4-DIAZAESPIRO[4.5]DEC-3-EN-1-IL)ACETAMIDA SUSTITUIDOS DE FORMULA (I), EN DONDE R1, R2 Y R4 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C4), ALCOXI(C1-C4), HALO, HALOALQUILO(C1-C4), CN, ENTRE OTROS; R3 ES H, METILO, ETILO, ALCOXI(C1-C4), HALO, HALOALQUILO(C1-C4), ENTRE OTROS; O R2 Y R3 JUNTOS FORMAN -O-CH2-O- Y -O-CH2-O-; R5 Y R7 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C4), ALCOXI(C1-C4), HALO, ENTRE OTROS; CON LA CONDICION DE QUE CUANDO R5 SE SELECCIONA ENTRE H, METILO, METOXI, Cl Y F, ENTONCES R7 NO SEA H; R6 ES H Y METILO; R8 ES H Y FLUOR; n ES 0,1 y 2. SON SELECCIONADOS: N-[2-(METILOXI)FENIL]-2-{2-OXO-3-[4-(TRIFLUOROMETIL)FENIL]-1,4-DIAZAESPIRO[4.5]DEC-3-EN-1-IL}ACETAMIDA, 2-[3-(4-BROMOFENIL)-2-OXO-1,4-DIAZAESPIRO[4.5]DEC-3-EN-1-IL]-N-(3,4-DIFLUOROFENIL)ACETAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MEDIADORES DE LOS TRANSPORTADORES DE GLICINA (GlyT1) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS Y NEUROPSIQUIATRICOS
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0605412A GB0605412D0 (en) | 2006-03-16 | 2006-03-16 | Compounds |
GB0605827A GB0605827D0 (en) | 2006-03-22 | 2006-03-22 | Compounds |
GB0622995A GB0622995D0 (en) | 2006-11-17 | 2006-11-17 | Compounds |
GB0701947A GB0701947D0 (en) | 2007-02-01 | 2007-02-01 | Compounds which inhibit the glycine transpoter and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080143A1 true PE20080143A1 (es) | 2008-04-02 |
Family
ID=38017148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000281A PE20080143A1 (es) | 2006-03-16 | 2007-03-14 | Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicina |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090062360A1 (es) |
EP (1) | EP1994010A1 (es) |
JP (1) | JP2009530246A (es) |
AR (1) | AR059839A1 (es) |
PE (1) | PE20080143A1 (es) |
TW (1) | TW200812976A (es) |
WO (1) | WO2007104775A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010517962A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | GlyT1トランスポーター阻害薬および神経学的および神経精神病学的障害の治療におけるその使用 |
GB0701955D0 (en) * | 2007-02-01 | 2007-03-14 | Glaxo Group Ltd | Compounds |
JP2010517963A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | 神経学的および神経精神病学的障害の治療におけるGlyT1トランスポーター阻害薬としての8−オキサ−1,4−ジアザスピロ[4,5]デク−3−エン−1−イルおよび1,4,8−トリアザスピロ[4,5]デク−3−エン−1−イルアセトアミド誘導体 |
TW200846328A (en) * | 2007-02-01 | 2008-12-01 | Glaxo Group Ltd | GlyT1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
EP2121624A1 (en) * | 2007-02-01 | 2009-11-25 | Glaxo Group Limited | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
WO2008092874A1 (en) * | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
GB0701985D0 (en) * | 2007-02-01 | 2007-03-14 | Glaxo Group Ltd | Compounds |
US20100317704A1 (en) * | 2007-09-11 | 2010-12-16 | Glaxo Group Limited a corporation | Spiro-condensed imidazolone derivatives inhibiting the glycine transporter |
JP2015157764A (ja) * | 2012-06-14 | 2015-09-03 | 大正製薬株式会社 | グリシントランスポーター阻害物質 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0130696D0 (en) | 2001-12-21 | 2002-02-06 | Smithkline Beecham Plc | Chemical Compounds |
CA2560256C (en) * | 2004-03-24 | 2013-02-19 | Merck & Co., Inc. | Heteroaryl piperidine glycine transporter inhibitors |
GB0408772D0 (en) * | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
WO2007014762A2 (en) * | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders |
-
2007
- 2007-03-14 US US12/282,677 patent/US20090062360A1/en not_active Abandoned
- 2007-03-14 TW TW096108664A patent/TW200812976A/zh unknown
- 2007-03-14 PE PE2007000281A patent/PE20080143A1/es not_active Application Discontinuation
- 2007-03-14 AR ARP070101036A patent/AR059839A1/es unknown
- 2007-03-14 EP EP07726905A patent/EP1994010A1/en not_active Withdrawn
- 2007-03-14 JP JP2008558817A patent/JP2009530246A/ja active Pending
- 2007-03-14 WO PCT/EP2007/052414 patent/WO2007104775A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AR059839A1 (es) | 2008-04-30 |
WO2007104775A1 (en) | 2007-09-20 |
TW200812976A (en) | 2008-03-16 |
EP1994010A1 (en) | 2008-11-26 |
US20090062360A1 (en) | 2009-03-05 |
JP2009530246A (ja) | 2009-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20080143A1 (es) | Compuestos 2-oxo-3-fenil-(1,4-diazaespiro[4.5]dec-3-en-1-il)acetamida sustituidos como inhibidores del transportador de glicina | |
PE20081704A1 (es) | Derivados de azacicloalcanos como inhibidores de estearoil-coenzima a delta-9 desaturasa | |
PE20081894A1 (es) | Derivados de isoindolina 4'-o-sustituidos y composiciones que los comprenden y metodos para usarlos | |
EA201171333A1 (ru) | Кристаллические сольваты и комплексы производных (1s)-1,5-ангидро-1-с-(3-((фенил)метил)фенил)-d-глюцитола с аминокислотами в качестве ингибиторов sglt2 для лечения диабета | |
NZ590268A (en) | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase | |
EA201070422A1 (ru) | Производные оксадиазола | |
PE20142099A1 (es) | Derivados de sulfonamida | |
PE20091843A1 (es) | Inhibidores de catepsina c | |
PE20091828A1 (es) | Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino como inhibidores de edg-2 | |
PE20110136A1 (es) | Compuestos organicos | |
PE20060692A1 (es) | Inhibidores bace | |
PE20120911A1 (es) | Derivados de prolina como inhibidores de catepsina | |
PE20142294A1 (es) | Compuestos de indol e indazol que activan la ampk | |
PE20091425A1 (es) | Derivados de aminotiazol | |
PE20131377A1 (es) | Triazina-oxadiazoles | |
PE20110150A1 (es) | Amidofenoxiindazoles como inhibidores de c-met | |
BR122012009489B8 (pt) | processo para produzir 2-etóxi-1-{[2-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso | |
PE20110062A1 (es) | N-(3-(3,5-dimetoxifenetil)-1h-pirazol-5-il)-4-(3,4-dimetilpiperazin-1-il)benzamida y sales del mismo | |
PE20070172A1 (es) | DERIVADOS BICICLICOS COMO INHIBIDORES DE p38 | |
PE20090297A1 (es) | Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis | |
PE20081545A1 (es) | Derivados de sulfonamida como inhibidores de acido graso sintasas | |
PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
EA200802329A1 (ru) | Производные триазола ii | |
PE20120834A1 (es) | Derivados de furopirimidindiona como moduladores de trpa1 | |
AR052330A1 (es) | Derivados de adamantano que comprenden quinoleinas sustituidas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |