DK2081435T3 - Inhibitorer af bruton's tyrosinkinase - Google Patents

Inhibitorer af bruton's tyrosinkinase Download PDF

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DK2081435T3
DK2081435T3 DK06850039.6T DK06850039T DK2081435T3 DK 2081435 T3 DK2081435 T3 DK 2081435T3 DK 06850039 T DK06850039 T DK 06850039T DK 2081435 T3 DK2081435 T3 DK 2081435T3
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compound
compounds
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btk
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DK06850039.6T
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Lee Honigberg
Erik Verner
Zhengying Pan
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Pharmacyclics Llc
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Claims (8)

1. Forbindelse med formlen (D):
formel D hvor: La er CH2, O, NH eller S; Ar er substitueret eller usubstitueret aryl, eller substitueret eller usubstitueret heteroaryl; Y er en eventuelt substitueret gruppe valgt blandt alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, og heteroaryl; Z er C(=0), 0C(=0), NHC(=0), C(=S), S(=0)x, 0S(=0)X, NHS(=0)x, hvor x er 1 eller 2; R7 og Rs er uafhængigt valgt blandt H, usubstitueret Ci-C4alkyl, substitueret Ci-C4alkyl, usubstitueret Ci-C4heteroalkyl, substitueret Ci-C4heteroalkyl, usubstitueret Cs-Cecycloalkyl, substitueret Cs-Cecycloalkyl, usubstitueret C2-C6heterocycloalkyl, og substitueret C2-C6heterocycloalkyl; eller R7 og Re sammen danner en binding; R6 er H, substitueret eller usubstitueret Ci-C4alkyl, substitueret eller usubstitueret Ci-C4heteroalkyl, Ci-C6alkoxyalkyl, Ci-C6alkylaminoalkyl, substitueret eller usubstitueret Cs-Cecycloalkyl, substitueret eller usubstitueret aryl, substitueret eller usubstitueret C2-Ceheterocycloalkyl, substitueret eller usubstitueret heteroaryl, Ci-C4alkyl(aryl), Ci- 2 C4alkyl(heteroaryl), Ci-C4alkyl(C3-C8Cycloalkyl), eller Ci-C4alkyl(C2-Csheterocycloalkyl); eller et farmaceutisk acceptabelt salt deraf.
2. Forbindelse ifølge krav 1, hvor U er O.
3. Forbindelse ifølge krav 1 eller 2, hvor Ar er phenyl.
4. Forbindelse ifølge et hvilket som helst af kravene 1-3, hvor Z er C(=0).
5. Forbindelse ifølge et hvilket som helst af kravene 1-4, hvor R7 og Rs hver er hydrogen.
6. Forbindelse ifølge et hvilket som helst af kravene 1-5, hvor Y er 5- eller 6-leddet cycloalkyl eller 5- eller 6-leddet heterocycloalkyl indeholdende 1 eller 2 N-atomer.
7. Isoleret og oprenset forbindelse med formlen:
8. Farmaceutisk sammensætning omfattende en terapeutisk effektiv mængde af en forbindelse ifølge et hvilket som helst af kravene 1-7, og en farmaceutisk acceptabel excipiens.
DK06850039.6T 2006-09-22 2006-12-28 Inhibitorer af bruton's tyrosinkinase DK2081435T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82672006P 2006-09-22 2006-09-22
US82859006P 2006-10-06 2006-10-06
PCT/US2006/049626 WO2008039218A2 (en) 2006-09-22 2006-12-28 Inhibitors of bruton's tyrosine kinase

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DK2081435T3 true DK2081435T3 (da) 2016-08-15

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