ITUB20152576A1 - Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi. - Google Patents

Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.

Info

Publication number
ITUB20152576A1
ITUB20152576A1 ITUB2015A002576A ITUB20152576A ITUB20152576A1 IT UB20152576 A1 ITUB20152576 A1 IT UB20152576A1 IT UB2015A002576 A ITUB2015A002576 A IT UB2015A002576A IT UB20152576 A ITUB20152576 A IT UB20152576A IT UB20152576 A1 ITUB20152576 A1 IT UB20152576A1
Authority
IT
Italy
Prior art keywords
ibrutinib
procedure
preparation
synthetic intermediate
new synthetic
Prior art date
Application number
ITUB2015A002576A
Other languages
English (en)
Original Assignee
Laboratorio Chimico Int S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Int S P A filed Critical Laboratorio Chimico Int S P A
Priority to ITUB2015A002576A priority Critical patent/ITUB20152576A1/it
Priority to JP2018504095A priority patent/JP2018525366A/ja
Priority to EP16766363.2A priority patent/EP3328863A1/en
Priority to US15/747,657 priority patent/US20180222909A1/en
Priority to PCT/IB2016/054476 priority patent/WO2017017619A1/en
Publication of ITUB20152576A1 publication Critical patent/ITUB20152576A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITUB2015A002576A 2015-07-29 2015-07-29 Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi. ITUB20152576A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITUB2015A002576A ITUB20152576A1 (it) 2015-07-29 2015-07-29 Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.
JP2018504095A JP2018525366A (ja) 2015-07-29 2016-07-27 イブルチニブの製法及び新規な合成中間体
EP16766363.2A EP3328863A1 (en) 2015-07-29 2016-07-27 Process for the preparation of ibrutinib and new synthesis intermediate
US15/747,657 US20180222909A1 (en) 2015-07-29 2016-07-27 Process for the preparation of ibrutinib and new synthesis intermediate
PCT/IB2016/054476 WO2017017619A1 (en) 2015-07-29 2016-07-27 Process for the preparation of ibrutinib and new synthesis intermediate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUB2015A002576A ITUB20152576A1 (it) 2015-07-29 2015-07-29 Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.

Publications (1)

Publication Number Publication Date
ITUB20152576A1 true ITUB20152576A1 (it) 2017-01-29

Family

ID=54347736

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUB2015A002576A ITUB20152576A1 (it) 2015-07-29 2015-07-29 Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.

Country Status (5)

Country Link
US (1) US20180222909A1 (it)
EP (1) EP3328863A1 (it)
JP (1) JP2018525366A (it)
IT (1) ITUB20152576A1 (it)
WO (1) WO2017017619A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039218A2 (en) * 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039218A2 (en) * 2006-09-22 2008-04-03 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANNA TURETSKY ET AL: "Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor", SCIENTIFIC REPORTS, vol. 4, 24 April 2014 (2014-04-24), pages 1 - 7, XP055213899, DOI: 10.1038/srep04782 *
KIM ET AL.: "Optimized near-IR fluorescent agents for in vivo imaging of Btk expression", BIOCONJUGATE CHEMISTRY, vol. 26, 27 May 2015 (2015-05-27), pages 1513 - 1518, XP002750926 *

Also Published As

Publication number Publication date
JP2018525366A (ja) 2018-09-06
EP3328863A1 (en) 2018-06-06
WO2017017619A1 (en) 2017-02-02
US20180222909A1 (en) 2018-08-09

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