BR112016006978A2 - inibidores de tirosina quinase de bruton - Google Patents
inibidores de tirosina quinase de brutonInfo
- Publication number
- BR112016006978A2 BR112016006978A2 BR112016006978A BR112016006978A BR112016006978A2 BR 112016006978 A2 BR112016006978 A2 BR 112016006978A2 BR 112016006978 A BR112016006978 A BR 112016006978A BR 112016006978 A BR112016006978 A BR 112016006978A BR 112016006978 A2 BR112016006978 A2 BR 112016006978A2
- Authority
- BR
- Brazil
- Prior art keywords
- tyrosine kinase
- bruton tyrosine
- disclosed
- conditions
- kinase inhibitors
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1/1 resumo inibidores de tirosina quinase de bruton são aqui revelados compostos que formam ligações covalentes com tirosina-quinase de bruton (btk). também são descritos inibidores irreversíveis de btk. além disso, inibidores reversíveis de btk também são descritos. também são reveladas composições farmacêuticas que incluem os compostos. métodos de utilização dos inibidores de btk são revelados, isoladamente ou em combinação com outros agentes terapêuticos, para o tratamento de doenças ou condições autoimunes, doenças ou condições heteroimunes, câncer, incluindo linfoma e doenças ou condições inflamatórias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361884888P | 2013-09-30 | 2013-09-30 | |
PCT/US2014/058132 WO2015048689A1 (en) | 2013-09-30 | 2014-09-29 | Inhibitors of bruton's tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016006978A2 true BR112016006978A2 (pt) | 2017-08-01 |
Family
ID=52740746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016006978A BR112016006978A2 (pt) | 2013-09-30 | 2014-09-29 | inibidores de tirosina quinase de bruton |
Country Status (20)
Country | Link |
---|---|
US (2) | US9624224B2 (pt) |
EP (1) | EP3052486A1 (pt) |
JP (1) | JP2016531941A (pt) |
KR (1) | KR20160062103A (pt) |
CN (1) | CN105764896A (pt) |
AR (1) | AR097862A1 (pt) |
AU (1) | AU2014324532A1 (pt) |
BR (1) | BR112016006978A2 (pt) |
CA (1) | CA2925124A1 (pt) |
CR (1) | CR20160203A (pt) |
DO (1) | DOP2016000071A (pt) |
EA (1) | EA201690618A1 (pt) |
IL (1) | IL244492A0 (pt) |
MA (1) | MA38961A1 (pt) |
PE (1) | PE20160560A1 (pt) |
PH (1) | PH12016500575A1 (pt) |
SG (1) | SG11201602421VA (pt) |
TN (1) | TN2016000094A1 (pt) |
TW (1) | TW201546061A (pt) |
WO (1) | WO2015048689A1 (pt) |
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EA031737B1 (ru) | 2010-06-03 | 2019-02-28 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) для лечения лейкоза и лимфомы |
JP2014520863A (ja) | 2011-07-13 | 2014-08-25 | ファーマサイクリックス,インク. | Bruton型チロシンキナーゼの阻害剤 |
ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
KR102334260B1 (ko) | 2013-03-14 | 2021-12-02 | 스미토모 다이니폰 파마 온콜로지, 인크. | Jak2 및 alk2 억제제 및 이들의 사용 방법 |
JP6458018B2 (ja) | 2013-07-02 | 2019-01-23 | ファーマサイクリックス エルエルシー | キナーゼ阻害剤としてのプリノン化合物 |
EP3119910A4 (en) | 2014-03-20 | 2018-02-21 | Pharmacyclics LLC | Phospholipase c gamma 2 and resistance associated mutations |
CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
CN108602834B (zh) * | 2016-02-05 | 2021-01-08 | 北京盛诺基医药科技股份有限公司 | 一种布鲁顿酪氨酸激酶抑制剂 |
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KR101956815B1 (ko) | 2017-02-14 | 2019-03-12 | 한국화학연구원 | 트리아졸로피리다진 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
US10370381B2 (en) | 2017-02-24 | 2019-08-06 | Gilead Sciences, Inc. | Inhibitors of bruton'S tyrosine kinase |
WO2018156901A1 (en) | 2017-02-24 | 2018-08-30 | Gilead Sciences, Inc. | Inhibitors of bruton's tyrosine kinase |
CN108570036A (zh) * | 2017-03-09 | 2018-09-25 | 北京赛林泰医药技术有限公司 | 一种btk抑制剂的多晶型物及其制备方法 |
KR102128018B1 (ko) | 2017-05-12 | 2020-06-30 | 한국화학연구원 | 피라졸로 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암, 자가면역질환 및 뇌질환의 예방 또는 치료용 약학적 조성물 |
WO2018208132A1 (en) * | 2017-05-12 | 2018-11-15 | Korea Research Institute Of Chemical Technology | Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient |
KR102032418B1 (ko) | 2017-06-15 | 2019-10-16 | 한국화학연구원 | 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
CN109748929A (zh) * | 2017-11-06 | 2019-05-14 | 苏州鹏旭医药科技有限公司 | 一种化合物的制备方法 |
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BR112020020246A8 (pt) | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
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EP3826684A4 (en) | 2018-07-26 | 2022-04-06 | Sumitomo Dainippon Pharma Oncology, Inc. | METHODS FOR TREATING DISEASES ASSOCIATED WITH ABNORMAL ACVR1 EXPRESSION AND ACVR1 INHIBITORS FOR USE THEREOF |
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2014
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- 2014-09-29 CR CR20160203A patent/CR20160203A/es unknown
- 2014-09-29 MA MA38961A patent/MA38961A1/fr unknown
- 2014-09-29 EP EP14848332.4A patent/EP3052486A1/en not_active Withdrawn
- 2014-09-29 TN TN2016000094A patent/TN2016000094A1/en unknown
- 2014-09-29 JP JP2016545269A patent/JP2016531941A/ja active Pending
- 2014-09-29 CN CN201480065396.6A patent/CN105764896A/zh active Pending
- 2014-09-29 PE PE2016000427A patent/PE20160560A1/es not_active Application Discontinuation
- 2014-09-29 AU AU2014324532A patent/AU2014324532A1/en not_active Abandoned
- 2014-09-29 WO PCT/US2014/058132 patent/WO2015048689A1/en active Application Filing
- 2014-09-29 EA EA201690618A patent/EA201690618A1/ru unknown
- 2014-09-29 US US14/500,897 patent/US9624224B2/en active Active
- 2014-09-29 SG SG11201602421VA patent/SG11201602421VA/en unknown
- 2014-09-29 KR KR1020167010963A patent/KR20160062103A/ko not_active Application Discontinuation
- 2014-09-29 BR BR112016006978A patent/BR112016006978A2/pt not_active Application Discontinuation
- 2014-09-30 TW TW103134098A patent/TW201546061A/zh unknown
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WO2015048689A8 (en) | 2015-05-07 |
CA2925124A1 (en) | 2015-04-02 |
JP2016531941A (ja) | 2016-10-13 |
IL244492A0 (en) | 2016-04-21 |
PE20160560A1 (es) | 2016-06-09 |
PH12016500575A1 (en) | 2016-07-25 |
AR097862A1 (es) | 2016-04-20 |
CN105764896A (zh) | 2016-07-13 |
EP3052486A1 (en) | 2016-08-10 |
KR20160062103A (ko) | 2016-06-01 |
EA201690618A1 (ru) | 2016-09-30 |
TW201546061A (zh) | 2015-12-16 |
DOP2016000071A (es) | 2016-09-15 |
US9624224B2 (en) | 2017-04-18 |
SG11201602421VA (en) | 2016-04-28 |
WO2015048689A1 (en) | 2015-04-02 |
US20170050970A1 (en) | 2017-02-23 |
TN2016000094A1 (en) | 2017-07-05 |
CR20160203A (es) | 2016-08-31 |
MA38961A1 (fr) | 2018-05-31 |
US20150094319A1 (en) | 2015-04-02 |
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