MX2011002484A - Algoritmo para diseñar inhibidores irreversibles. - Google Patents

Algoritmo para diseñar inhibidores irreversibles.

Info

Publication number
MX2011002484A
MX2011002484A MX2011002484A MX2011002484A MX2011002484A MX 2011002484 A MX2011002484 A MX 2011002484A MX 2011002484 A MX2011002484 A MX 2011002484A MX 2011002484 A MX2011002484 A MX 2011002484A MX 2011002484 A MX2011002484 A MX 2011002484A
Authority
MX
Mexico
Prior art keywords
algorithm
irreversible inhibitors
designing
designing irreversible
inhibitors
Prior art date
Application number
MX2011002484A
Other languages
English (en)
Inventor
Deqiang Niu
Juswinder Singh
Russel Colyn Petter
Original Assignee
Avila Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avila Therapeutics Inc filed Critical Avila Therapeutics Inc
Publication of MX2011002484A publication Critical patent/MX2011002484A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/203—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C49/205—Methyl-vinyl ketone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Computing Systems (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La invención se refiere a un algoritmo y método para diseñar un inhibidor que covalentemente une un polipéptido objetivo. El algoritmo y el método pueden ser utilizados para convertir rápida u eficientemente inhibidores reversibles en inhibidores irreversibles.
MX2011002484A 2008-09-05 2009-09-04 Algoritmo para diseñar inhibidores irreversibles. MX2011002484A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9478208P 2008-09-05 2008-09-05
PCT/US2009/056025 WO2010028236A1 (en) 2008-09-05 2009-09-04 Algorithm for designing irreversible inhibitors

Publications (1)

Publication Number Publication Date
MX2011002484A true MX2011002484A (es) 2011-09-26

Family

ID=41797504

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011002484A MX2011002484A (es) 2008-09-05 2009-09-04 Algoritmo para diseñar inhibidores irreversibles.

Country Status (16)

Country Link
US (1) US20100185419A1 (es)
EP (1) EP2352827A4 (es)
JP (2) JP2012501654A (es)
KR (1) KR101341876B1 (es)
CN (2) CN102405284B (es)
AU (1) AU2009289602B2 (es)
BR (1) BRPI0918970A2 (es)
CA (1) CA2735937A1 (es)
HK (1) HK1169139A1 (es)
IL (1) IL211553A0 (es)
MX (1) MX2011002484A (es)
MY (1) MY156789A (es)
NZ (2) NZ603495A (es)
RU (2) RU2014150660A (es)
SG (1) SG193859A1 (es)
WO (1) WO2010028236A1 (es)

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Also Published As

Publication number Publication date
RU2011108531A (ru) 2012-10-10
AU2009289602B2 (en) 2014-02-13
AU2009289602A1 (en) 2010-03-11
EP2352827A4 (en) 2016-07-20
CN105574346A (zh) 2016-05-11
NZ603495A (en) 2014-05-30
RU2014150660A (ru) 2015-07-20
RU2542963C2 (ru) 2015-02-27
SG193859A1 (en) 2013-10-30
CN102405284A (zh) 2012-04-04
WO2010028236A1 (en) 2010-03-11
US20100185419A1 (en) 2010-07-22
NZ621143A (en) 2016-08-26
CN102405284B (zh) 2016-01-20
EP2352827A1 (en) 2011-08-10
JP2012501654A (ja) 2012-01-26
KR101341876B1 (ko) 2013-12-20
KR20110084169A (ko) 2011-07-21
JP2015062428A (ja) 2015-04-09
HK1169139A1 (zh) 2013-01-18
MY156789A (en) 2016-03-31
CA2735937A1 (en) 2010-03-11
BRPI0918970A2 (pt) 2019-09-24
IL211553A0 (en) 2011-05-31

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