DK2638064T3 - Celledyrkningsmedie og fremgangsmåde til proteinekspression, hvilket medie og hvilken fremgangsmåde omfatter en PAM inhibitor - Google Patents
Celledyrkningsmedie og fremgangsmåde til proteinekspression, hvilket medie og hvilken fremgangsmåde omfatter en PAM inhibitor Download PDFInfo
- Publication number
- DK2638064T3 DK2638064T3 DK11782121.5T DK11782121T DK2638064T3 DK 2638064 T3 DK2638064 T3 DK 2638064T3 DK 11782121 T DK11782121 T DK 11782121T DK 2638064 T3 DK2638064 T3 DK 2638064T3
- Authority
- DK
- Denmark
- Prior art keywords
- medium
- cell culture
- protein expression
- method comprises
- culture medium
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/71—Oxidoreductases (EC 1.)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10190532A EP2450375A1 (en) | 2010-11-09 | 2010-11-09 | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| PCT/EP2011/069756 WO2012062810A2 (en) | 2010-11-09 | 2011-11-09 | Cell culture medium and process for protein expression, said medium and process comprising a pam inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2638064T3 true DK2638064T3 (da) | 2021-10-04 |
Family
ID=43795181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11782121.5T DK2638064T3 (da) | 2010-11-09 | 2011-11-09 | Celledyrkningsmedie og fremgangsmåde til proteinekspression, hvilket medie og hvilken fremgangsmåde omfatter en PAM inhibitor |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9062337B2 (da) |
| EP (2) | EP2450375A1 (da) |
| JP (2) | JP6298295B2 (da) |
| KR (2) | KR101991215B1 (da) |
| CN (2) | CN107629995A (da) |
| AU (1) | AU2011328166B2 (da) |
| CA (1) | CA2816394A1 (da) |
| DK (1) | DK2638064T3 (da) |
| HU (1) | HUE055573T2 (da) |
| PL (1) | PL2638064T3 (da) |
| SG (2) | SG10201602507UA (da) |
| SI (1) | SI2638064T1 (da) |
| WO (1) | WO2012062810A2 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| BRPI0716762A2 (pt) | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
| EP2921501A1 (en) | 2008-10-20 | 2015-09-23 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
| CA2738499A1 (en) | 2008-10-20 | 2010-04-29 | Abbott Laboratories | Viral inactivation during purification of antibodies |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| JP6438387B2 (ja) * | 2012-04-16 | 2018-12-12 | レツク・フアーマシユーテイカルズ・デー・デー | タンパク質発現のための細胞株におけるアミド化アミノ酸形成の減少 |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| KR20150043523A (ko) | 2012-09-02 | 2015-04-22 | 애브비 인코포레이티드 | 단백질 불균일성의 제어 방법 |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| CN105473614B (zh) | 2013-08-20 | 2019-11-01 | 斯洛文尼亚莱柯制药股份有限公司 | 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法 |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| KR102543033B1 (ko) | 2016-10-17 | 2023-06-12 | 엔진 바이오사이언스 리미티드 | 치료적 단백질의 불균일성을 감소시키기 위한 연속 공정 |
| US20220177818A1 (en) | 2019-04-01 | 2022-06-09 | The Automation Partnership (Cambridge ) Ltd. | Operation process for a cell cultivation system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2243827B2 (en) * | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
| WO2006084111A2 (en) * | 2005-02-04 | 2006-08-10 | Glaxo Group Limited | Optimization of heterologous polypeptide expression |
| US20080227134A9 (en) * | 2005-09-16 | 2008-09-18 | Unigene Laboratories Inc. | Glyoxylate assays and their use of inden tifying natural amidated compounds |
| EP1947190B1 (en) * | 2005-10-18 | 2017-11-29 | Ajinomoto Co., Inc. | Process for production of succinic acid |
| NZ606767A (en) | 2010-07-15 | 2015-08-28 | Oleg Iliich Epshtein | A method of increasing the effect of an activated-potentiated form of an antibody |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
-
2010
- 2010-11-09 EP EP10190532A patent/EP2450375A1/en not_active Withdrawn
-
2011
- 2011-11-09 CN CN201710966840.7A patent/CN107629995A/zh active Pending
- 2011-11-09 SI SI201131994T patent/SI2638064T1/sl unknown
- 2011-11-09 WO PCT/EP2011/069756 patent/WO2012062810A2/en active Application Filing
- 2011-11-09 EP EP11782121.5A patent/EP2638064B1/en active Active
- 2011-11-09 SG SG10201602507UA patent/SG10201602507UA/en unknown
- 2011-11-09 HU HUE11782121A patent/HUE055573T2/hu unknown
- 2011-11-09 PL PL11782121T patent/PL2638064T3/pl unknown
- 2011-11-09 SG SG2013034871A patent/SG190182A1/en unknown
- 2011-11-09 CN CN201180053542XA patent/CN103298830A/zh active Pending
- 2011-11-09 KR KR1020187019845A patent/KR101991215B1/ko active IP Right Grant
- 2011-11-09 CA CA2816394A patent/CA2816394A1/en not_active Abandoned
- 2011-11-09 AU AU2011328166A patent/AU2011328166B2/en active Active
- 2011-11-09 KR KR1020137013920A patent/KR101905204B1/ko active IP Right Grant
- 2011-11-09 JP JP2013538186A patent/JP6298295B2/ja active Active
- 2011-11-09 US US13/883,986 patent/US9062337B2/en active Active
- 2011-11-09 DK DK11782121.5T patent/DK2638064T3/da active
-
2015
- 2015-05-26 US US14/721,679 patent/US10106828B2/en active Active
-
2016
- 2016-08-24 JP JP2016163954A patent/JP2017035084A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SG10201602507UA (en) | 2016-05-30 |
| HUE055573T2 (hu) | 2021-12-28 |
| EP2638064A2 (en) | 2013-09-18 |
| CN103298830A (zh) | 2013-09-11 |
| CA2816394A1 (en) | 2012-05-18 |
| KR101905204B1 (ko) | 2018-10-05 |
| WO2012062810A2 (en) | 2012-05-18 |
| AU2011328166A1 (en) | 2013-05-30 |
| AU2011328166B2 (en) | 2017-02-23 |
| EP2450375A1 (en) | 2012-05-09 |
| JP2013541963A (ja) | 2013-11-21 |
| US9062337B2 (en) | 2015-06-23 |
| WO2012062810A3 (en) | 2012-07-05 |
| CN107629995A (zh) | 2018-01-26 |
| KR20180082643A (ko) | 2018-07-18 |
| EP2638064B1 (en) | 2021-07-21 |
| KR20130131355A (ko) | 2013-12-03 |
| KR101991215B1 (ko) | 2019-09-30 |
| SG190182A1 (en) | 2013-06-28 |
| JP6298295B2 (ja) | 2018-03-20 |
| US10106828B2 (en) | 2018-10-23 |
| PL2638064T3 (pl) | 2021-12-20 |
| US20150267238A1 (en) | 2015-09-24 |
| JP2017035084A (ja) | 2017-02-16 |
| SI2638064T1 (sl) | 2021-11-30 |
| US20130337506A1 (en) | 2013-12-19 |
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