PL2638064T3 - Pożywka do hodowli komórkowej i sposób ekspresji białka, przy czym wymieniona pożywka i sposób obejmują inhibitory pam - Google Patents
Pożywka do hodowli komórkowej i sposób ekspresji białka, przy czym wymieniona pożywka i sposób obejmują inhibitory pamInfo
- Publication number
- PL2638064T3 PL2638064T3 PL11782121T PL11782121T PL2638064T3 PL 2638064 T3 PL2638064 T3 PL 2638064T3 PL 11782121 T PL11782121 T PL 11782121T PL 11782121 T PL11782121 T PL 11782121T PL 2638064 T3 PL2638064 T3 PL 2638064T3
- Authority
- PL
- Poland
- Prior art keywords
- medium
- cell culture
- protein expression
- culture medium
- pam inhibitor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/71—Oxidoreductases (EC 1.)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10190532A EP2450375A1 (en) | 2010-11-09 | 2010-11-09 | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| PCT/EP2011/069756 WO2012062810A2 (en) | 2010-11-09 | 2011-11-09 | Cell culture medium and process for protein expression, said medium and process comprising a pam inhibitor |
| EP11782121.5A EP2638064B1 (en) | 2010-11-09 | 2011-11-09 | Cell culture medium and process for protein expression, said medium and process comprising a pam inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2638064T3 true PL2638064T3 (pl) | 2021-12-20 |
Family
ID=43795181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11782121T PL2638064T3 (pl) | 2010-11-09 | 2011-11-09 | Pożywka do hodowli komórkowej i sposób ekspresji białka, przy czym wymieniona pożywka i sposób obejmują inhibitory pam |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9062337B2 (pl) |
| EP (2) | EP2450375A1 (pl) |
| JP (2) | JP6298295B2 (pl) |
| KR (2) | KR101991215B1 (pl) |
| CN (2) | CN103298830A (pl) |
| AU (1) | AU2011328166B2 (pl) |
| CA (1) | CA2816394A1 (pl) |
| DK (1) | DK2638064T3 (pl) |
| HU (1) | HUE055573T2 (pl) |
| PL (1) | PL2638064T3 (pl) |
| SG (2) | SG10201602507UA (pl) |
| SI (1) | SI2638064T1 (pl) |
| WO (1) | WO2012062810A2 (pl) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY161866A (en) | 2006-09-13 | 2017-05-15 | Abbvie Inc | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| CN104974251A (zh) | 2008-10-20 | 2015-10-14 | Abbvie公司 | 在抗体纯化过程中的病毒灭活 |
| SG10201702922VA (en) | 2008-10-20 | 2017-06-29 | Abbvie Inc | Isolation and purification of antibodies using protein a affinity chromatography |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP2839003B1 (en) * | 2012-04-16 | 2018-06-27 | LEK Pharmaceuticals d.d. | Reduction of formation of amidated amino acids in cell lines for protein expression |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
| WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| JP2016527911A (ja) | 2013-08-20 | 2016-09-15 | レック・ファーマシューティカルズ・ディー・ディーＬｅｋ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｄ．Ｄ． | ポリペプチドのα−アミド化および／またはＣ末端アミノ酸開裂を制御するための細胞培養用培地およびプロセス |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| PL3500586T3 (pl) | 2016-10-17 | 2021-09-27 | Enzene Biosciences Ltd. | Sposób ciągły zmniejszania heterogeniczności białka terapeutycznego |
| US20220177818A1 (en) | 2019-04-01 | 2022-06-09 | The Automation Partnership (Cambridge ) Ltd. | Operation process for a cell cultivation system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953041A4 (en) * | 1996-08-30 | 2003-01-29 | Life Technologies Inc | SERUM-FREE CULTURAL MEDIUM FOR MAMMAL CELLS AND THEIR USE |
| US20080160577A1 (en) * | 2005-02-04 | 2008-07-03 | Glaxo Group Limited | Optimization of Heterologous Polypeptide Expression |
| US20080227134A9 (en) * | 2005-09-16 | 2008-09-18 | Unigene Laboratories Inc. | Glyoxylate assays and their use of inden tifying natural amidated compounds |
| JP5088136B2 (ja) * | 2005-10-18 | 2012-12-05 | 味の素株式会社 | コハク酸の製造方法 |
| EA030566B1 (ru) | 2010-07-15 | 2018-08-31 | Олег Ильич ЭПШТЕЙН | Способ повышения терапевтической эффективности активированной-потенцированной формы антитела к эндогенной биомолекуле и фармацевтическая композиция |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
-
2010
- 2010-11-09 EP EP10190532A patent/EP2450375A1/en not_active Withdrawn
-
2011
- 2011-11-09 AU AU2011328166A patent/AU2011328166B2/en active Active
- 2011-11-09 HU HUE11782121A patent/HUE055573T2/hu unknown
- 2011-11-09 DK DK11782121.5T patent/DK2638064T3/da active
- 2011-11-09 CN CN201180053542XA patent/CN103298830A/zh active Pending
- 2011-11-09 KR KR1020187019845A patent/KR101991215B1/ko active IP Right Grant
- 2011-11-09 EP EP11782121.5A patent/EP2638064B1/en active Active
- 2011-11-09 SG SG10201602507UA patent/SG10201602507UA/en unknown
- 2011-11-09 PL PL11782121T patent/PL2638064T3/pl unknown
- 2011-11-09 CA CA2816394A patent/CA2816394A1/en not_active Abandoned
- 2011-11-09 US US13/883,986 patent/US9062337B2/en active Active
- 2011-11-09 SI SI201131994T patent/SI2638064T1/sl unknown
- 2011-11-09 JP JP2013538186A patent/JP6298295B2/ja active Active
- 2011-11-09 SG SG2013034871A patent/SG190182A1/en unknown
- 2011-11-09 WO PCT/EP2011/069756 patent/WO2012062810A2/en active Application Filing
- 2011-11-09 KR KR1020137013920A patent/KR101905204B1/ko active IP Right Grant
- 2011-11-09 CN CN201710966840.7A patent/CN107629995A/zh active Pending
-
2015
- 2015-05-26 US US14/721,679 patent/US10106828B2/en active Active
-
2016
- 2016-08-24 JP JP2016163954A patent/JP2017035084A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US9062337B2 (en) | 2015-06-23 |
| EP2638064B1 (en) | 2021-07-21 |
| CA2816394A1 (en) | 2012-05-18 |
| SG190182A1 (en) | 2013-06-28 |
| DK2638064T3 (da) | 2021-10-04 |
| JP6298295B2 (ja) | 2018-03-20 |
| SI2638064T1 (sl) | 2021-11-30 |
| EP2638064A2 (en) | 2013-09-18 |
| JP2013541963A (ja) | 2013-11-21 |
| JP2017035084A (ja) | 2017-02-16 |
| KR20130131355A (ko) | 2013-12-03 |
| KR101991215B1 (ko) | 2019-09-30 |
| CN103298830A (zh) | 2013-09-11 |
| AU2011328166B2 (en) | 2017-02-23 |
| US10106828B2 (en) | 2018-10-23 |
| HUE055573T2 (hu) | 2021-12-28 |
| WO2012062810A3 (en) | 2012-07-05 |
| KR20180082643A (ko) | 2018-07-18 |
| EP2450375A1 (en) | 2012-05-09 |
| CN107629995A (zh) | 2018-01-26 |
| WO2012062810A2 (en) | 2012-05-18 |
| SG10201602507UA (en) | 2016-05-30 |
| KR101905204B1 (ko) | 2018-10-05 |
| US20130337506A1 (en) | 2013-12-19 |
| AU2011328166A1 (en) | 2013-05-30 |
| US20150267238A1 (en) | 2015-09-24 |
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