SG10201510384UA - Cell culture improvements - Google Patents

Cell culture improvements

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Publication number
SG10201510384UA
SG10201510384UA SG10201510384UA SG10201510384UA SG10201510384UA SG 10201510384U A SG10201510384U A SG 10201510384UA SG 10201510384U A SG10201510384U A SG 10201510384UA SG 10201510384U A SG10201510384U A SG 10201510384UA SG 10201510384U A SG10201510384U A SG 10201510384UA
Authority
SG
Singapore
Prior art keywords
cell culture
culture improvements
improvements
cell
Prior art date
Application number
SG10201510384UA
Inventor
Itzcoatl A Pla
Joseph C Matuck
John C Fann
Christof Schulz
Nicole A Roy
David F Bruton
James Mcintire
Yu-Hsiang David Chang
Thomas Seewoester
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US84515806P priority Critical
Priority to US87637406P priority
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of SG10201510384UA publication Critical patent/SG10201510384UA/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39184386&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201510384U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0037Serum-free medium, which may still contain naturally-sourced components
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
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    • C12N5/0603Embryonic cells ; Embryoid bodies
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    • C07K2317/00Immunoglobulins specific features
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/33Insulin
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    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
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    • C12N2511/00Cells for large scale production
SG10201510384UA 2006-09-13 2007-09-13 Cell culture improvements SG10201510384UA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US84515806P true 2006-09-13 2006-09-13
US87637406P true 2006-12-21 2006-12-21

Publications (1)

Publication Number Publication Date
SG10201510384UA true SG10201510384UA (en) 2016-01-28

Family

ID=39184386

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201510384UA SG10201510384UA (en) 2006-09-13 2007-09-13 Cell culture improvements
SG2011065711A SG174804A1 (en) 2006-09-13 2007-09-13 Cell culture improvements
SG2013049846A SG192441A1 (en) 2006-09-13 2007-09-13 Cell culture improvements

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG2011065711A SG174804A1 (en) 2006-09-13 2007-09-13 Cell culture improvements
SG2013049846A SG192441A1 (en) 2006-09-13 2007-09-13 Cell culture improvements

Country Status (17)

Country Link
US (10) US8093045B2 (en)
EP (4) EP2064314A4 (en)
JP (3) JP5878682B2 (en)
KR (2) KR20140132017A (en)
CN (6) CN103276033A (en)
AU (1) AU2007294731B2 (en)
BR (1) BRPI0716762A2 (en)
CA (5) CA2663442A1 (en)
IL (1) IL197444D0 (en)
MX (4) MX353340B (en)
MY (1) MY161866A (en)
NO (1) NO20091439L (en)
NZ (2) NZ597334A (en)
RU (2) RU2518289C2 (en)
SG (3) SG10201510384UA (en)
TW (4) TWI548747B (en)
WO (1) WO2008033517A2 (en)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
CN103275221B (en) 1996-02-09 2016-08-17 艾伯维生物技术有限公司 Human antibody binding to human TNFα of
AU2003267999B2 (en) * 2002-07-19 2010-03-11 Abbvie Biotechnology Ltd Treatment of TNFalpha related disorders
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
MY150740A (en) * 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
TWI556829B (en) 2004-04-09 2016-11-11 Abbvie Biotechnology Ltd Multiple-variable dose regimen for treating tnfα-related disorders
GB0414054D0 (en) 2004-06-23 2004-07-28 Owen Mumford Ltd Improvements relating to automatic injection devices
EP1807111A4 (en) * 2004-10-08 2009-05-27 Abbott Biotech Ltd Respiratory syncytial virus (rsv) infection
NZ591701A (en) 2005-05-16 2012-11-30 Abbott Biotech Ltd Use of tnf inhibitor for treatment of erosive polyarthritis
NZ595340A (en) 2005-11-01 2013-04-26 Abbott Biotech Ltd Methods and compositions for diagnosing ankylosing spondylitis using biomarkers
US7863426B2 (en) * 2006-04-05 2011-01-04 Abbott Biotechnology Ltd. Antibody purification
US9605064B2 (en) * 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
EP2007426A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd Uses and compositions for treatment of psoriatic arthritis
US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
US20090280065A1 (en) * 2006-04-10 2009-11-12 Willian Mary K Uses and Compositions for Treatment of Psoriasis
EP2012586A4 (en) 2006-04-10 2010-08-18 Abbott Biotech Ltd Uses and compositions for treatment of ankylosing spondylitis
US20090317399A1 (en) * 2006-04-10 2009-12-24 Pollack Paul F Uses and compositions for treatment of CROHN'S disease
WO2007120656A2 (en) 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of rheumatoid arthritis
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
US20100021451A1 (en) 2006-06-08 2010-01-28 Wong Robert L Uses and compositions for treatment of ankylosing spondylitis
US20080311043A1 (en) * 2006-06-08 2008-12-18 Hoffman Rebecca S Uses and compositions for treatment of psoriatic arthritis
WO2008005315A2 (en) 2006-06-30 2008-01-10 Abbott Biotechnology Ltd. Automatic injection device
SG10201510384UA (en) 2006-09-13 2016-01-28 Abbvie Inc Cell culture improvements
EP2684895A1 (en) * 2006-10-27 2014-01-15 AbbVie Biotechnology Ltd Crystalline anti-hTNFalpha antibodies
EP2528002B1 (en) * 2007-04-16 2015-11-04 Momenta Pharmaceuticals, Inc. Defined glycoprotein products and related methods
KR101574355B1 (en) * 2007-04-26 2015-12-11 추가이 세이야쿠 가부시키가이샤 How to culture the cell with a high concentration of amino acid-containing medium
EP2165194A4 (en) * 2007-05-31 2010-09-08 Abbott Lab BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNF-alpha INHIBITORS IN AUTOIMMUNE DISORDERS
WO2008154543A2 (en) * 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis
WO2009011782A2 (en) * 2007-07-13 2009-01-22 Abbott Biotechnology Ltd. METHODS AND COMPOSITIONS FOR PULMONARY ADMINISTRATION OF A TNFa INHIBITOR
RU2010107994A (en) 2007-08-08 2011-09-20 Эбботт Лэборетриз (Us) Compositions and methods for crystallizing antibodies
TWI629064B (en) 2007-11-30 2018-07-11 艾伯維生物技術有限責任公司 Protein formulations and manufacturing method therefor
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US8415094B2 (en) * 2007-12-21 2013-04-09 Jaffar Ali bin M. Abdullah Protein-free gamete and embryo handling and culture media products
US20090271164A1 (en) * 2008-01-03 2009-10-29 Peng Joanna Z Predicting long-term efficacy of a compound in the treatment of psoriasis
EP2250251B1 (en) 2008-01-09 2017-11-22 Sartorius Stedim Cellca GmbH Improved culture media additive and process for using it
WO2009090189A1 (en) 2008-01-15 2009-07-23 Abbott Gmbh & Co.Kg Powdered protein compositions and methods of making same
JP4883067B2 (en) 2008-09-29 2012-02-22 株式会社日立プラントテクノロジー METHOD culture apparatus and culture
BRPI0920027A2 (en) * 2008-10-20 2015-10-06 Abbott Lab Isolation and purification of antibodies using affinity chromatography on protein
DK2373783T3 (en) 2008-12-30 2018-01-29 Baxalta GmbH A method of improving cell growth using alkyl-amine-N-oxide (aanox)
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
DK2427483T3 (en) 2009-05-07 2015-05-04 Hemarina Novel hemoglobin and uses thereof
SG176217A1 (en) * 2009-05-28 2011-12-29 Boehringer Ingelheim Int Method for a rational cell culturing process
NZ600069A (en) 2009-12-15 2015-02-27 Abbvie Biotechnology Ltd Improved firing button for automatic injection device
CN102869784A (en) 2010-04-07 2013-01-09 动量制药公司 High mannose glycans
EP3330370A1 (en) * 2010-04-26 2018-06-06 Novartis AG Process for cultivation of cho cells
ES2685607T3 (en) 2010-06-03 2018-10-10 Abbvie Biotechnology Ltd Uses and compositions for treating hidradenitis suppurativa (HS)
US9458222B2 (en) * 2010-07-08 2016-10-04 Baxalta Incorporated Method of producing recombinant ADAMTS13 in cell culture
EP2611904A2 (en) * 2010-08-31 2013-07-10 Friesland Brands B.V. Culture medium for eukaryotic cells
TWI606840B (en) 2010-11-11 2017-12-01 Abbvie Biotechnology Ltd Improved high concentration anti-tnfα antibody liquid formulations
MX360402B (en) 2011-01-24 2018-10-31 Abbvie Biotechnology Ltd Automatic injection devices having overmolded gripping surfaces.
WO2012110435A1 (en) * 2011-02-14 2012-08-23 Basf Se Bio process additives
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CA2852021C (en) * 2011-10-21 2018-08-28 Pfizer Inc. Addition of iron to improve cell culture
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
CA2926384A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. Low acidic species compositions and methods for producing and using the same
US20130281355A1 (en) * 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
BR112015004467A2 (en) 2012-09-02 2017-03-21 Abbvie Inc method for controlling the heterogeneity of proteins
US9512214B2 (en) * 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
AR093460A1 (en) 2012-11-14 2015-06-10 Merck Patent Ges Mit Beschränkter Haftung Cell culture media
US20140199728A1 (en) * 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
SG11201507230PA (en) * 2013-03-12 2015-10-29 Abbvie Inc Human antibodies that bind human tnf-alpha and methods of preparing the same
AU2014240431A1 (en) 2013-03-14 2015-08-27 Abbvie Inc. Low acidic species compositions and methods for producing the same using displacement chromatography
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2014151901A1 (en) * 2013-03-14 2014-09-25 Abbvie Inc. Improvement of mammalian cell culture performance through surfactant supplementation of feed media
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
KR20160068000A (en) * 2013-10-14 2016-06-14 아레스 트레이딩 에스.아. New medium for high performance mammalian fed-batch cultures
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP3083933A1 (en) * 2013-12-20 2016-10-26 Biogen MA Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
EP2923707A1 (en) 2014-03-28 2015-09-30 Hemarina Blood substitute with respiratory pigment
PE13262016A1 (en) * 2014-04-10 2016-12-11 Bayer Healthcare Llc Powder formulation of medium composed and preparation method of liquid culture medium Cell
KR101699761B1 (en) * 2014-05-23 2017-01-25 주식회사 비비에이치씨 Method for Preparing Induced Pluripotency Stem Cell from Mesenchymal Stem Cell Using Phlorotannin Fraction
RU2017101195A3 (en) * 2014-06-18 2019-02-19
WO2016004197A1 (en) 2014-07-03 2016-01-07 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt
WO2016007764A1 (en) 2014-07-09 2016-01-14 Abbvie Inc. Methods for modulating the glycosylation profile of recombinant proteins using non-commonly used sugars
EP3279317A4 (en) * 2015-03-30 2018-11-21 Ajinomoto Co., Inc. Chelated iron-containing culture medium for neural stem cells
CN106190948A (en) * 2015-05-07 2016-12-07 上海津曼特生物科技有限公司 CHO-S cell semisolid medium as well as preparation method and application thereof
CN105018425B (en) * 2015-07-09 2018-09-28 广州白云山拜迪生物医药有限公司 A non-animal derived component medium peripheral blood lymphocytes
CN105441378A (en) * 2015-12-22 2016-03-30 肇庆大华农生物药品有限公司 Serum-free medium used for culturing Vero cells, and preparation method thereof
WO2017195789A1 (en) * 2016-05-10 2017-11-16 興人ライフサイエンス株式会社 Composition for culture medium
WO2018018613A1 (en) 2016-07-29 2018-02-01 广东东阳光药业有限公司 Cell culture medium and culture method for increasing purity of antibody
WO2018116198A1 (en) 2016-12-23 2018-06-28 Serum Institute Of India Private Limited Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof
US10280217B2 (en) * 2017-09-19 2019-05-07 American Air Liquide, Inc. Cell culture additives and their use for increased bioprotein production from cells
CN107904200B (en) * 2017-10-20 2018-10-16 通化东宝生物科技有限公司 An expression of adalimumab joint media and its application
WO2019099891A1 (en) * 2017-11-16 2019-05-23 Life Technologies Corporation Streamlined methods for making liquid media
EP3492582A1 (en) * 2017-12-01 2019-06-05 UCB Biopharma SPRL Cell culture methods

Family Cites Families (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5672502A (en) * 1985-06-28 1997-09-30 Celltech Therapeutics Limited Animal cell culture
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5045468A (en) 1986-12-12 1991-09-03 Cell Enterprises, Inc. Protein-free culture medium which promotes hybridoma growth
US4965195A (en) 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US4968607A (en) 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
AU643427B2 (en) 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US6451983B2 (en) * 1989-08-07 2002-09-17 Peptech Limited Tumor necrosis factor antibodies
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5110913A (en) 1990-05-25 1992-05-05 Miles Inc. Antibody purification method
WO1991018982A1 (en) 1990-06-05 1991-12-12 Immunex Corporation Type ii interleukin-1 receptors
US5096816A (en) 1990-06-05 1992-03-17 Cetus Corporation In vitro management of ammonia's effect on glycosylation of cell products through pH control
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
US20070298040A1 (en) * 1991-03-18 2007-12-27 Centocor, Inc. Methods of treating seronegative arthropathy with anti-TNF antibodies
US20060246073A1 (en) * 1991-03-18 2006-11-02 Knight David M Anti-TNF antibodies and peptides of human tumor necrosis factor
US20060018907A1 (en) 2000-08-07 2006-01-26 Centocor, Inc. Anti-TNF antibodies and peptides of human tumor necrosis factor
US20050249735A1 (en) * 2000-08-07 2005-11-10 Centocor, Inc. Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor
CA2736076A1 (en) 1991-03-18 1992-09-19 New York University Monoclonal and chimeric antibodies specific for human tumor necrosis factor
US6277969B1 (en) * 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US5656272A (en) * 1991-03-18 1997-08-12 New York University Medical Center Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
US7192584B2 (en) * 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co., Inc. A method for reducing the immunogenicity of antibody variable domains
ES2199216T3 (en) 1991-07-15 2004-02-16 The Wellcome Foundation Limited Antibody production.
AT274055T (en) 1991-10-25 2004-09-15 Immunex Corp new cytokine
DK0832229T3 (en) 1995-06-07 2004-05-03 Immunex Corp CD40L mutein
EP0666312A1 (en) 1994-02-08 1995-08-09 Wolfgang A. Renner Process for the improvement of mammalian cell growth
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5856179A (en) * 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5741705A (en) 1995-02-23 1998-04-21 Quest International Flavors & Food Ingredients Company, Division Of Indopco, Inc. Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5721121A (en) 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
JP4306813B2 (en) * 1995-09-19 2009-08-05 アスビオファーマ株式会社 A new method for culturing animal cells
AR005035A1 (en) * 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Process for preparing recombinant proteins in e. coli, by fermentation with high cell concentration.
AU708981B2 (en) 1996-01-11 1999-08-19 Immunex Corporation Expression augmenting sequence elements (ease) for eukaryotic expression systems
CN103275221B (en) * 1996-02-09 2016-08-17 艾伯维生物技术有限公司 Human antibody binding to human TNFα of
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
PT802257E (en) 1996-04-19 2003-01-31 Nestle Sa immortalized line of epithelial cells of the human colon
AU4751697A (en) 1996-10-10 1998-05-05 Douglas Danner Animal cell culture media comprising plant-derived nutrients
US20040171152A1 (en) * 1996-10-10 2004-09-02 Invitrogen Corporation Animal cell culture media comprising non-animal or plant-derived nutrients
SI1900751T1 (en) 1996-11-27 2010-03-31 Genentech Inc Affinity purification of polypeptide on protein a matrix
US20020045207A1 (en) 1997-10-31 2002-04-18 Lynne A. Krummen Glycoprotein production process
WO1999032605A1 (en) 1997-12-19 1999-07-01 Novo Nordisk A/S Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents
WO1999057246A1 (en) * 1998-05-01 1999-11-11 Life Technologies, Inc. Animal cell culture media comprising non-animal or plant-derived nutrients
IL139035D0 (en) 1998-05-06 2001-11-25 Genentech Inc Protein purification by ion exchange chromatography
US6528286B1 (en) 1998-05-29 2003-03-04 Genentech, Inc. Mammalian cell culture process for producing glycoproteins
ES2277438T3 (en) 1998-07-01 2007-07-01 Takara Bio Inc. Methods of gene transfer.
US6406909B1 (en) * 1998-07-10 2002-06-18 Chugai Seiyaku Kabushiki Kaisha Serum-free medium for culturing animal cells
US6210924B1 (en) 1998-08-11 2001-04-03 Amgen Inc. Overexpressing cyclin D 1 in a eukaryotic cell line
US7883704B2 (en) 1999-03-25 2011-02-08 Abbott Gmbh & Co. Kg Methods for inhibiting the activity of the P40 subunit of human IL-12
US6914128B1 (en) * 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
AT409379B (en) 1999-06-02 2002-07-25 Baxter Ag Medium for the protein and serum-free cultivation of cells
US6190523B1 (en) 1999-07-20 2001-02-20 Basf Corporation Electrocoat coating composition and process for electrocoating a substrate
EP1220934B1 (en) 1999-09-27 2005-12-21 Genentech, Inc. Methods for making recombinant proteins using apoptosis inhibitors
EP1222298B1 (en) 1999-10-13 2005-12-07 Immunex Corporation Vectors and methods for recombinant protein expression
AR026743A1 (en) * 1999-12-09 2003-02-26 Pharmacia Ab Peptide production
EP1254216B1 (en) 2000-02-08 2006-06-07 Genentech, Inc. Improved galactosylation of recombinant glycoproteins
WO2001058956A2 (en) * 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
WO2001077362A1 (en) * 2000-04-06 2001-10-18 Chugai Seiyaku Kabushiki Kaisha Immunoassay of anti-hm1.24 antibody
US7598055B2 (en) 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
EP1175931A1 (en) 2000-07-25 2002-01-30 Computer Cell Culture Center S.A. Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
NZ562811A (en) 2000-08-07 2009-05-31 Centocor Inc Anti-TNF antibodies, compositions, methods and uses
US20040120952A1 (en) * 2000-08-07 2004-06-24 Centocor, Inc Anti-TNF antibodies and peptides of human tumor necrosis factor
US7288390B2 (en) * 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
US6635448B2 (en) 2000-08-21 2003-10-21 Clonexdevelopment, Inc. Methods and compositions for increasing protein yield from a cell culture
KR20040039472A (en) 2001-10-02 2004-05-10 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Method for production of recombinant proteins in eukaryote cells
US6693173B2 (en) 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
US20030096414A1 (en) 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
WO2002094192A2 (en) 2001-05-24 2002-11-28 Human Genome Sciences, Inc. Antibodies against tumor necrosis factor delta (april)
US7223848B2 (en) 2001-06-05 2007-05-29 Genetics Institute, Llc Methods for purifying Fc-containing proteins
EP1404813A4 (en) 2001-06-13 2004-11-24 Genentech Inc Methods of culturing animal cells and polypeptide production in animal cells
HU0700103A3 (en) 2001-08-03 2012-09-28 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
US20030157108A1 (en) 2001-10-25 2003-08-21 Genentech, Inc. Glycoprotein compositions
US20030201229A1 (en) 2002-02-04 2003-10-30 Martin Siwak Process for prefiltration of a protein solution
RU2004119816A (en) 2001-11-28 2006-01-10 Сандоз АГ (CH) cell culture method
AU2002356749A1 (en) 2001-11-28 2003-06-10 Hermann Katinger Process for the production of polypeptides in mammalian cell cultures
AT425989T (en) 2001-12-21 2009-04-15 Immunex Corp Protein purification methods
WO2003066662A2 (en) 2002-02-05 2003-08-14 Genentech, Inc. Protein purification
CA2417689C (en) 2002-03-05 2006-05-09 F. Hoffmann-La Roche Ag Improved methods for growing mammalian cells in vitro
EP1497444B1 (en) * 2002-03-27 2015-11-04 Immunex Corporation Methods for increasing polypeptide production
US20030190710A1 (en) 2002-03-28 2003-10-09 Devries Ruth L. Control of glycoforms in IgG
CA2481837A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. Production process for antibody composition
US20040029229A1 (en) 2002-05-20 2004-02-12 Reeves Philip J. High level protein expression system
DE60313188T2 (en) 2002-07-15 2007-12-20 Immunex Corp., Thousand Oaks Methods and media to control the sialylation of proteins produced by mammalian cells
US7067279B1 (en) 2002-08-23 2006-06-27 Immunex Corporation Cell culture performance with betaine
US6974681B1 (en) 2002-08-23 2005-12-13 Immunex Corporation Cell culture performance with vanadate
US6924124B1 (en) * 2002-08-23 2005-08-02 Immunex Corporation Feeding strategies for cell culture
US7208585B2 (en) 2002-09-18 2007-04-24 Genencor International, Inc. Protein purification
US6890736B1 (en) * 2002-09-20 2005-05-10 Immunex Corporation Methods for producing proteins in cultured cells
US20040071694A1 (en) 2002-10-14 2004-04-15 Devries Peter J. Erythropoietin receptor binding antibodies
WO2004058944A2 (en) 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
KR20050088136A (en) 2002-12-23 2005-09-01 브리스톨-마이어스 스큅 컴퍼니 Mammalian cell culture processes for protein production
AU2004215653B2 (en) 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
US20060104968A1 (en) * 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
DK1623019T4 (en) 2003-05-15 2017-03-27 Wyeth Llc Limited glucose to the animal cell culture
CA2531595C (en) 2003-07-28 2015-12-08 Genentech, Inc. Reducing protein a leaching during protein a affinity chromatography
GB2404665B (en) 2003-08-08 2005-07-06 Cambridge Antibody Tech Cell culture
JP4619362B2 (en) * 2003-08-08 2011-01-26 メディミューン リミテッド Myeloma cell culture in a transferrin-free, low-iron medium
WO2005035748A1 (en) 2003-10-10 2005-04-21 Novo Nordisk Health Care Ag Method for large-scale production of a polypeptide in eukaryote cells and a culture vessel suitable therefor
KR101321876B1 (en) 2003-10-27 2013-10-28 와이어쓰 엘엘씨 Removal of high molecular weight aggregates using hydroxyapatite chromatography
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
AU2004309114A1 (en) 2003-12-23 2005-07-14 Laboratoires Serono Sa Process for the production of tumor necrosis factor-binding proteins
US8084032B2 (en) 2004-01-21 2011-12-27 Ajinomoto Co., Inc. Purification method which prevents denaturation of an antibody
CN1238498C (en) * 2004-02-12 2006-01-25 陈志南 Method for parameter control of the process for culturing serum-suspension free animal cell
WO2005087915A2 (en) 2004-03-08 2005-09-22 Biovest International, Inc. Use of ethanolamine for enhancing cell growth in membrane systems
SE0400886D0 (en) 2004-04-02 2004-04-02 Amersham Biosciences Ab The process of purification
US20060018902A1 (en) 2004-04-09 2006-01-26 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
US20060127950A1 (en) 2004-04-15 2006-06-15 Massachusetts Institute Of Technology Methods and products related to the improved analysis of carbohydrates
KR20070008645A (en) 2004-05-04 2007-01-17 노보 노르디스크 헬스 케어 악티엔게젤샤프트 O-linked glycoforms of polypeptides and method to manufacture them
US20060001890A1 (en) * 2004-07-02 2006-01-05 Asml Holding N.V. Spatial light modulator as source module for DUV wavefront sensor
TWI384069B (en) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals Production of polypeptides
UA112529C2 (en) 2004-09-30 2016-09-26 Байер Хелскеа Елелсі The device and process integrated continuous production of biological molecules
WO2006050050A2 (en) 2004-10-29 2006-05-11 Centocor, Inc. Chemically defined media compositions
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
JP2006143601A (en) 2004-11-16 2006-06-08 Masahito Hitosugi Blood viscosity-reducing agent
AT541919T (en) 2005-02-11 2012-02-15 Novo Nordisk Healthcare Ag includes production of a protein in serum-free cell culture, the plant a protein hydrolyzate from
AU2006223180B2 (en) 2005-03-11 2011-11-24 Wyeth Llc A method of weak partitioning chromatography
US20090203055A1 (en) 2005-04-18 2009-08-13 Massachusetts Institute Of Technology Compositions and methods for RNA interference with sialidase expression and uses thereof
US7247457B2 (en) 2005-04-26 2007-07-24 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Detection and identification of enteroviruses by semi-nested amplification of the enterovirus VP1 protein
EP1891207A2 (en) 2005-06-03 2008-02-27 Biovitrum AB Process for cultivating animal cells comprising the feeding of plant-derived peptones
EP1888638A2 (en) 2005-06-03 2008-02-20 Genentech, Inc. Method of producing antibodies with modified fucosylation level
JP2008543839A (en) 2005-06-14 2008-12-04 アムジェン インコーポレーテッドAmgen Inc. Self-buffering protein formulations
EP2388274A1 (en) 2005-06-17 2011-11-23 Janssen Alzheimer Immunotherapy Methods of purifying anti A Beta antibodies
US20080219952A1 (en) 2005-08-26 2008-09-11 Ares Trading S.A. Process For the Preparation of Glycosylated Interferon Beta
DE102005046225B4 (en) 2005-09-28 2012-01-05 Cellca Gmbh Improved cell culture medium
AR058140A1 (en) 2005-10-24 2008-01-23 Wyeth Corp Method of protein production using anti-senescence compounds
CA2630811C (en) 2005-12-08 2016-05-31 Amgen Inc. Improved production of glycoproteins using manganese
US20070190057A1 (en) 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
EP2032600A2 (en) 2006-05-19 2009-03-11 Glycofi, Inc. Erythropoietin compositions
JP2010510963A (en) 2006-06-14 2010-04-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC Method of purifying antibodies using ceramic hydroxyapatite
KR101495549B1 (en) 2006-07-13 2015-02-25 와이어쓰 엘엘씨 Production of glycoproteins
WO2008031020A2 (en) 2006-09-08 2008-03-13 Wyeth Arginine wash in protein purification using affinity chromatography
SG10201510384UA (en) 2006-09-13 2016-01-28 Abbvie Inc Cell culture improvements
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
WO2008036600A2 (en) 2006-09-18 2008-03-27 Genentech, Inc. Methods of protein production
WO2008055260A2 (en) 2006-11-03 2008-05-08 Wyeth Glycolysis-inhibiting substances in cell culture
EP2089424B1 (en) 2006-12-06 2015-07-01 JCR PHARMACEUTICALS Co., LTD. Method for production of human erythropoietin
JP5586235B2 (en) 2007-03-02 2014-09-10 ワイス・エルエルシー Use of copper and glutamate in cell culture for the production of a polypeptide
WO2008121616A2 (en) 2007-03-30 2008-10-09 Medimmune, Inc. Antibodies with decreased deamidation profiles
EP2134853B1 (en) 2007-04-03 2018-07-18 Oxyrane UK Limited Glycosylation of molecules
EP2528002B1 (en) 2007-04-16 2015-11-04 Momenta Pharmaceuticals, Inc. Defined glycoprotein products and related methods
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP1988101A1 (en) 2007-05-04 2008-11-05 Novo Nordisk A/S Improvement of factor VIII polypeptide titers in cell cultures
WO2008135498A2 (en) 2007-05-04 2008-11-13 Novo Nordisk A/S Prevention of protein degradation in mammalian cell cultures
ES2392701T3 (en) 2007-05-11 2012-12-13 Amgen Inc. Improved media feeding
US20100221823A1 (en) 2007-06-11 2010-09-02 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
DE17196350T1 (en) 2007-07-09 2018-12-27 Genentech, Inc. Prevent the disulfide bond reduction during recombinant production of polypeptides
WO2009023562A2 (en) 2007-08-09 2009-02-19 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
NZ584839A (en) 2007-10-30 2012-07-27 Genentech Inc Antibody purification by cation exchange chromatography
TWI629064B (en) 2007-11-30 2018-07-11 艾伯維生物技術有限責任公司 Protein formulations and manufacturing method therefor
KR101798813B1 (en) 2007-12-27 2017-11-16 박스알타 인코퍼레이티드 Cell culture processes
US20090186396A1 (en) 2008-01-18 2009-07-23 Gagnon Peter S Enhanced purification of phosphorylated and nonphosphorylated biomolecules by apatite chromatography
AU2009223054A1 (en) 2008-03-11 2009-09-17 Genentech, Inc. Antibodies with enhanced ADCC function
WO2009129226A1 (en) 2008-04-15 2009-10-22 Talecris Biotherapeutics, Inc. Two-stage ultrafiltration/diafiltration
AU2009242453B2 (en) 2008-05-02 2014-12-04 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
US8318416B2 (en) 2008-08-08 2012-11-27 Biogen Idec Ma Inc. Nutrient monitoring and feedback control for increased bioproduct production
BRPI0823046A2 (en) 2008-08-14 2015-07-28 Genentech Inc Methods for removing a contaminant chromatography using ion exchange membrane by displacement of the native protein
US20100081172A1 (en) 2008-09-26 2010-04-01 Eureka Therapeutics, Inc. N-Glycans and Uses Thereof
EP2350130B1 (en) 2008-10-31 2018-10-03 Wyeth LLC Purification of acidic proteins using ceramic hydroxyapatite chromatography
EP2376118A1 (en) 2008-12-09 2011-10-19 F. Hoffmann-La Roche AG Method for obtaining an excipient-free antibody solution
WO2010072381A1 (en) 2008-12-22 2010-07-01 F. Hoffmann-La Roche Ag Immunoglobulin purification
JP5785098B2 (en) 2009-01-08 2015-09-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ Separation method using a single polymer phase system
CA2752393A1 (en) 2009-03-05 2010-09-10 Biogen Idec Ma Inc. Purification of immunoglobulins
JP5755136B2 (en) 2009-03-27 2015-07-29 旭化成メディカル株式会社 Virus removal method of the high density monoclonal antibody solution
EP2419436A1 (en) 2009-04-13 2012-02-22 Bristol-Myers Squibb Company Protein purification by citrate precipitation
AU2010240569A1 (en) 2009-04-20 2011-10-20 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
SG176217A1 (en) 2009-05-28 2011-12-29 Boehringer Ingelheim Int Method for a rational cell culturing process
US20120277165A1 (en) 2009-06-05 2012-11-01 Collins Brian E Methods of modulating fucosylation of glycoproteins
BR112012000242A2 (en) 2009-07-06 2015-09-08 Genentech Inc method for cultivation in batch eukaryotic cells, method for perfusion culture of eukaryotic cells and apparatus for culturing eukaryotic cells
SG178078A1 (en) 2009-07-24 2012-03-29 Hoffmann La Roche Optimizing the production of antibodies
WO2011015926A1 (en) 2009-08-03 2011-02-10 Avesthagen Limited A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein
PL2462158T3 (en) 2009-08-06 2018-05-30 F. Hoffmann-La Roche Ag Method to improve virus removal in protein purification
WO2011019622A1 (en) 2009-08-14 2011-02-17 Genentech, Inc. Cell culture methods to make antibodies with enhanced adcc function
WO2011024025A1 (en) 2009-08-28 2011-03-03 Avesthagen Limited An erythropoietin analogue and a method thereof
KR101764449B1 (en) 2009-09-01 2017-08-02 제넨테크, 인크. Enhanced protein purification through a modified protein a elution
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
WO2011049798A1 (en) 2009-10-20 2011-04-28 Merck Sharp & Dohme Corp. Use of mixed mode chromatography for the capture and purification of basic antibody products
EP2499973A1 (en) 2009-11-10 2012-09-19 Hitachi Medical Corporation Ultrasonic diagnosis device
WO2011065940A1 (en) 2009-11-24 2011-06-03 Biogen Idec Ma Inc. Method of supplementing culture media to prevent undesirable amino acid substitutions
EP2507627A2 (en) 2009-12-04 2012-10-10 Momenta Pharmaceuticals, Inc. Antennary fucosylation in glycoproteins from cho cells
US8277649B2 (en) 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
EP3272764A1 (en) 2009-12-18 2018-01-24 Novartis AG Method for affinity chromatography
CN102869784A (en) 2010-04-07 2013-01-09 动量制药公司 High mannose glycans
SG185038A1 (en) 2010-04-26 2012-11-29 Novartis Ag Improved cell culture medium
EP3330370A1 (en) 2010-04-26 2018-06-06 Novartis AG Process for cultivation of cho cells
RU2614125C2 (en) 2010-05-28 2017-03-22 Дженентек, Инк. Reduction of level of lactate and increasing of production of polypeptide by inhibiting expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
WO2012019160A1 (en) 2010-08-05 2012-02-09 Amgen Inc. Dipeptides to enhance yield and viability from cell cultures
WO2012030512A1 (en) 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
KR101898302B1 (en) 2010-10-15 2018-09-13 제이씨알 파마 가부시키가이샤 Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
EP2450375A1 (en) 2010-11-09 2012-05-09 Sandoz Gmbh Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor
CN103429609A (en) 2010-12-08 2013-12-04 安姆根有限公司 Ion exchange chromatography in presence of amino acid
WO2012084829A1 (en) 2010-12-21 2012-06-28 F. Hoffmann-La Roche Ag Isoform enriched antibody preparation and method for obtaining it
WO2012094623A2 (en) 2011-01-07 2012-07-12 Abbott Laboratories Anti-il-12/il-23 antibodies and uses thereof
EP2683821B1 (en) 2011-03-06 2018-07-25 Merck Serono SA Low fucose cell lines and uses thereof
ES2685079T3 (en) 2011-03-25 2018-10-05 F. Hoffmann-La Roche Ag Purification procedures novel proteins
EP2511293A1 (en) 2011-04-13 2012-10-17 LEK Pharmaceuticals d.d. A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
US9133493B2 (en) 2011-04-21 2015-09-15 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
US9670519B2 (en) 2011-04-29 2017-06-06 Biocon Limited Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
US20120283419A1 (en) 2011-05-03 2012-11-08 Avantor Performance Materials, Inc. Separation of protein monomers from aggregates by solid weak anion exchange support functionalized with amine moieties
US9562252B2 (en) 2011-05-13 2017-02-07 Biogen Ma Inc. Methods of preventing and removing trisulfide bonds
WO2013006461A1 (en) 2011-07-01 2013-01-10 Biogen Idec Ma Inc. Cholesterol-based media supplementals for cell culture
EA201391826A1 (en) 2011-07-01 2014-04-30 Амген Инк. The cultivation of mammalian cells
US9475858B2 (en) 2011-07-08 2016-10-25 Momenta Pharmaceuticals, Inc. Cell culture process
WO2013013013A2 (en) 2011-07-21 2013-01-24 Alnylam Pharmaceuticals, Inc. Compositions and methods for producing modified glycoproteins
RU2650873C2 (en) 2011-10-19 2018-04-17 Рош Гликарт Аг Separation method for fucosylated antibodies
EP2773439A4 (en) 2011-10-31 2015-07-01 Merck Sharp & Dohme Chromatography process for resolving heterogeneous antibody aggregates

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