CY1117587T1 - Αναστολεις κινασης τυροσινης bruton - Google Patents
Αναστολεις κινασης τυροσινης brutonInfo
- Publication number
- CY1117587T1 CY1117587T1 CY20161100196T CY161100196T CY1117587T1 CY 1117587 T1 CY1117587 T1 CY 1117587T1 CY 20161100196 T CY20161100196 T CY 20161100196T CY 161100196 T CY161100196 T CY 161100196T CY 1117587 T1 CY1117587 T1 CY 1117587T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bruton
- tyrus
- suspensions
- movement
- compounds
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940124291 BTK inhibitor Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 abstract 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 abstract 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 abstract 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002427 irreversible effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
Αποκαλυπτόμενες στο παρόν είναι ενώσεις που σχηματίζουν ομοιοπολικούς δεσμούς με κινάση τυροσίνης Bruton (Btk). Επίσης περιγραφόμενη είναι μη αντιστρεπτοί αναστολείς Btk. Μέθοδοι για την παρασκευή των ενώσεων αποκαλύπτονται. Επίσης αποκαλυπτόμενες είναι φαρμακευτικές συνθέσεις που περιλαμβάνουν τις ενώσεις. Αποκαλύπτονται μέθοδοι χρήσης των αναστολέων Btk, μόνων ή σε συνδυασμό με άλλους θεραπευτικούς παράγοντες, για τη θεραπεία χρόνιας λεμφοκυτταρικής λευχαιμίας.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US82672006P | 2006-09-22 | 2006-09-22 | |
US82859006P | 2006-10-06 | 2006-10-06 | |
EP12166305.8A EP2526934B1 (en) | 2006-09-22 | 2006-12-28 | Inhibitors of bruton's tyrosine kinase |
Publications (1)
Publication Number | Publication Date |
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CY1117587T1 true CY1117587T1 (el) | 2017-03-15 |
Family
ID=39225888
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100100T CY1112513T1 (el) | 2006-09-22 | 2012-01-27 | Αναστολεις της κινασης τυροσινης του bruton |
CY2015016C CY2015016I2 (el) | 2006-09-22 | 2015-04-03 | Αναστολεις της κινασης τυροσινης του bruton |
CY20151100453T CY1116295T1 (el) | 2006-09-22 | 2015-05-20 | Αναστολεις της κινασης τυροσινης toy bruton |
CY20161100196T CY1117587T1 (el) | 2006-09-22 | 2016-03-07 | Αναστολεις κινασης τυροσινης bruton |
CY20161100734T CY1117840T1 (el) | 2006-09-22 | 2016-07-26 | Αναστολεις κινασης τυροσινης bruton |
CY20161100765T CY1117897T1 (el) | 2006-09-22 | 2016-08-03 | Αναστολεις κινασης τυροσινης bruton |
CY2016041C CY2016041I2 (el) | 2006-09-22 | 2016-11-15 | Αναστολεις κινασης τυροσινης bruton |
CY20161101348T CY1119209T1 (el) | 2006-09-22 | 2016-12-27 | Αναστολεις κινασης τυροσινης bruton |
CY20171100248T CY1118666T1 (el) | 2006-09-22 | 2017-02-22 | Αναστολεις κινασης τυροσινης bruton |
CY2017012C CY2017012I2 (el) | 2006-09-22 | 2017-03-31 | Αναστολεις κινασης τυροσινης bruton |
CY20181100404T CY1120135T1 (el) | 2006-09-22 | 2018-04-17 | Αναστολεις κινασης τυροσινης bruton |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
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CY20121100100T CY1112513T1 (el) | 2006-09-22 | 2012-01-27 | Αναστολεις της κινασης τυροσινης του bruton |
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CY20161100734T CY1117840T1 (el) | 2006-09-22 | 2016-07-26 | Αναστολεις κινασης τυροσινης bruton |
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CY2016041C CY2016041I2 (el) | 2006-09-22 | 2016-11-15 | Αναστολεις κινασης τυροσινης bruton |
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CY20171100248T CY1118666T1 (el) | 2006-09-22 | 2017-02-22 | Αναστολεις κινασης τυροσινης bruton |
CY2017012C CY2017012I2 (el) | 2006-09-22 | 2017-03-31 | Αναστολεις κινασης τυροσινης bruton |
CY20181100404T CY1120135T1 (el) | 2006-09-22 | 2018-04-17 | Αναστολεις κινασης τυροσινης bruton |
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