EA202091742A1 - ПРОИЗВОДНЫЕ ХРОМЕНА В КАЧЕСТВЕ ИНГИБИТОРОВ ВЗАИМОДЕЙСТВИЯ TCR-Nck - Google Patents

ПРОИЗВОДНЫЕ ХРОМЕНА В КАЧЕСТВЕ ИНГИБИТОРОВ ВЗАИМОДЕЙСТВИЯ TCR-Nck

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Publication number
EA202091742A1
EA202091742A1 EA202091742A EA202091742A EA202091742A1 EA 202091742 A1 EA202091742 A1 EA 202091742A1 EA 202091742 A EA202091742 A EA 202091742A EA 202091742 A EA202091742 A EA 202091742A EA 202091742 A1 EA202091742 A1 EA 202091742A1
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EA
Eurasian Patent Office
Prior art keywords
tcr
inhibitors
chromene derivatives
nck interaction
nck
Prior art date
Application number
EA202091742A
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English (en)
Inventor
Хулио Кастро
Андрес Гахете Матеос
Питер Дж. Мачин
Кристофер Лорен Вандойсен
Original Assignee
Артакс Биофарма Инк.
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Application filed by Артакс Биофарма Инк. filed Critical Артакс Биофарма Инк.
Publication of EA202091742A1 publication Critical patent/EA202091742A1/ru

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

В настоящем изобретении предложены соединения, которые модулируют взаимодействие TCR с Nck, содержащие их композиции и способы лечения с их применением.
EA202091742A 2018-02-27 2019-02-27 ПРОИЗВОДНЫЕ ХРОМЕНА В КАЧЕСТВЕ ИНГИБИТОРОВ ВЗАИМОДЕЙСТВИЯ TCR-Nck EA202091742A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862635834P 2018-02-27 2018-02-27
PCT/US2019/019856 WO2019169001A1 (en) 2018-02-27 2019-02-27 Chromene derivatives as inhibitors of tcr-nck interaction

Publications (1)

Publication Number Publication Date
EA202091742A1 true EA202091742A1 (ru) 2021-02-19

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EA202091742A EA202091742A1 (ru) 2018-02-27 2019-02-27 ПРОИЗВОДНЫЕ ХРОМЕНА В КАЧЕСТВЕ ИНГИБИТОРОВ ВЗАИМОДЕЙСТВИЯ TCR-Nck

Country Status (15)

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US (4) US10696663B2 (ru)
EP (1) EP3759086A1 (ru)
JP (3) JP7317032B2 (ru)
KR (1) KR20200140262A (ru)
CN (2) CN112189009B (ru)
AU (2) AU2019229258B2 (ru)
BR (1) BR112020017386A2 (ru)
CA (1) CA3091202A1 (ru)
CO (1) CO2020010537A2 (ru)
EA (1) EA202091742A1 (ru)
IL (2) IL301120A (ru)
MX (2) MX2020008814A (ru)
PH (1) PH12020500638A1 (ru)
SG (1) SG11202008067QA (ru)
WO (1) WO2019169001A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019169001A1 (en) 2018-02-27 2019-09-06 Artax Biopharma Inc. Chromene derivatives as inhibitors of tcr-nck interaction

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