BRPI0622054B8 - composto e composição farmacêutica - Google Patents

composto e composição farmacêutica

Info

Publication number
BRPI0622054B8
BRPI0622054B8 BRPI0622054A BRPI0622054A BRPI0622054B8 BR PI0622054 B8 BRPI0622054 B8 BR PI0622054B8 BR PI0622054 A BRPI0622054 A BR PI0622054A BR PI0622054 A BRPI0622054 A BR PI0622054A BR PI0622054 B8 BRPI0622054 B8 BR PI0622054B8
Authority
BR
Brazil
Prior art keywords
disclosed
compounds
conditions
btk
compound
Prior art date
Application number
BRPI0622054A
Other languages
English (en)
Inventor
Verner Erik
Honigberg Lee
Pan Zhengying
Original Assignee
Oxford Amherst Llc
Pharmacyclics Llc
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39225888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0622054(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oxford Amherst Llc, Pharmacyclics Llc, Pharmacyclics Inc filed Critical Oxford Amherst Llc
Publication of BRPI0622054A2 publication Critical patent/BRPI0622054A2/pt
Publication of BRPI0622054B1 publication Critical patent/BRPI0622054B1/pt
Publication of BRPI0622054B8 publication Critical patent/BRPI0622054B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

composto, composição farmacêutica, tirosina quinase inibida, e, metodo para tratar uma condição ou uma doença. aqui revelados estão compostos que formam ligações covalentes com a tirosina quinase de bruton (btk). também descritos estão inibidores irreversíveis da btk. métodos para a preparação dos compostos são revelados. também revelados estão composições farmacêuticas que incluem os compostos. métodos de uso dos inibidores de btk são revelados, sozinhos ou em combinação com outros agentes terapêuticos, para o tratamento de doenças ou condições autoimunes, doenças ou condições heteroimunes, câncer, incluindo linfoma, e doenças ou condições inflamatórias.
BRPI0622054A 2006-09-22 2006-12-28 composto e composição farmacêutica BRPI0622054B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US82672006P 2006-09-22 2006-09-22
US60/826,720 2006-09-22
US60/826720 2006-09-22
US82859006P 2006-10-06 2006-10-06
US60/828,590 2006-10-06
US60/828590 2006-10-06
PCT/US2006/049626 WO2008039218A2 (en) 2006-09-22 2006-12-28 Inhibitors of bruton's tyrosine kinase

Publications (3)

Publication Number Publication Date
BRPI0622054A2 BRPI0622054A2 (pt) 2010-11-09
BRPI0622054B1 BRPI0622054B1 (pt) 2018-02-06
BRPI0622054B8 true BRPI0622054B8 (pt) 2021-05-25

Family

ID=39225888

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0622277-3A BRPI0622277A2 (pt) 2006-09-22 2006-12-28 composto, composição farmacêutica, e, tirosina quinase inibida
BRPI0622054A BRPI0622054B8 (pt) 2006-09-22 2006-12-28 composto e composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0622277-3A BRPI0622277A2 (pt) 2006-09-22 2006-12-28 composto, composição farmacêutica, e, tirosina quinase inibida

Country Status (28)

Country Link
US (48) US7514444B2 (pt)
EP (11) EP2529621B1 (pt)
JP (4) JP4934197B2 (pt)
KR (4) KR101464424B1 (pt)
CN (4) CN102887900B (pt)
AT (1) ATE531263T1 (pt)
AU (2) AU2006348662B8 (pt)
BR (2) BRPI0622277A2 (pt)
CA (3) CA2663116C (pt)
CY (11) CY1112513T1 (pt)
DK (7) DK2526771T3 (pt)
EA (3) EA020001B1 (pt)
ES (8) ES2564647T3 (pt)
FR (1) FR15C0029I2 (pt)
HK (3) HK1129274A1 (pt)
HU (10) HUE029095T2 (pt)
IL (1) IL197550A0 (pt)
LT (7) LT2529622T (pt)
LU (3) LU92692I2 (pt)
MX (3) MX347525B (pt)
NL (1) NL300728I2 (pt)
NZ (3) NZ575650A (pt)
PL (8) PL2081435T3 (pt)
PT (7) PT2526771T (pt)
SG (2) SG10201503235VA (pt)
SI (8) SI2526934T1 (pt)
WO (1) WO2008039218A2 (pt)
ZA (4) ZA200901784B (pt)

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CA2561950C (en) 2004-04-02 2010-04-20 Osi Pharmaceuticals, Inc. 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
US20100279994A1 (en) * 2005-06-21 2010-11-04 Inifinity Discovery, Inc. Ansamycin Formulations and Methods of Use Thereof
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