PL3426244T3 - Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania - Google Patents
Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowaniaInfo
- Publication number
- PL3426244T3 PL3426244T3 PL17764038.0T PL17764038T PL3426244T3 PL 3426244 T3 PL3426244 T3 PL 3426244T3 PL 17764038 T PL17764038 T PL 17764038T PL 3426244 T3 PL3426244 T3 PL 3426244T3
- Authority
- PL
- Poland
- Prior art keywords
- dehydrogenase inhibitors
- phosphoglycerate dehydrogenase
- phosphoglycerate
- inhibitors
- dehydrogenase
- Prior art date
Links
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305940P | 2016-03-09 | 2016-03-09 | |
| PCT/US2017/021436 WO2017156179A1 (en) | 2016-03-09 | 2017-03-08 | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3426244T3 true PL3426244T3 (pl) | 2023-09-25 |
Family
ID=59789712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17764038.0T PL3426244T3 (pl) | 2016-03-09 | 2017-03-08 | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11014882B2 (pl) |
| EP (2) | EP4234552A3 (pl) |
| ES (1) | ES2949357T3 (pl) |
| PL (1) | PL3426244T3 (pl) |
| WO (1) | WO2017156179A1 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3884939T3 (pl) | 2016-03-09 | 2024-02-26 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| EP4234552A3 (en) | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| CN111909040A (zh) * | 2019-05-10 | 2020-11-10 | 南京莱克施德药业有限公司 | 一种Elagolix中间体2-氟-6-三氟甲基苄胺的制备方法 |
| WO2021173962A1 (en) * | 2020-02-28 | 2021-09-02 | Genemo, Inc. | Methods and materials for diagnosis and treatment of neuronal disorder |
| KR20220144399A (ko) * | 2020-04-07 | 2022-10-26 | 테오리아 사이언스 인크. | 세포외 소포의 분비를 억제하는 세포외 소포 분비 억제제, 및 그 용도 |
| CN116981656B (zh) | 2021-03-17 | 2025-09-26 | 三井化学株式会社 | 锂(n-羰基)磺酰胺化合物、锂二次电池用添加剂、锂二次电池用非水电解液、锂二次电池前体、锂二次电池、及锂二次电池的制造方法 |
| WO2024126453A1 (en) | 2022-12-15 | 2024-06-20 | Boehringer Ingelheim International Gmbh | New substituted indole-2-carboxamides as phgdh inhibitors |
| EP4637757A1 (en) | 2022-12-19 | 2025-10-29 | Chiesi Farmaceutici S.p.A. | Phosphoglicerate dehydrogenase inhibitors for the treatment of fibrosis |
| CN117603123B (zh) * | 2023-11-04 | 2026-03-13 | 郑州大学 | 新型吲哚类hdac6小分子抑制剂、制备方法和应用 |
| WO2025125295A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Thieno-indole amide derivatives as phgdh inhibitors |
| WO2025125292A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | New phosphoglicerate dehydrogenase inhibitors for the treatment of fibrosis |
| WO2025125293A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Thienopyrimidylamine derivatives as phgdh inhibitors |
| WO2025233464A1 (en) | 2024-05-10 | 2025-11-13 | Chiesi Farmaceutici S.P.A. | Process and intermediates for the preparation of a phosphoglicerate dehydrogenase inhibitor |
| WO2025233465A1 (en) | 2024-05-10 | 2025-11-13 | Chiesi Farmaceutici S.P.A. | Process and intermediates for the preparation of a phosphoglicerate dehydrogenase inhibitor |
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| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US5639600A (en) | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| DE60045474D1 (de) * | 1999-01-13 | 2011-02-17 | Univ New York State Res Found | Neues verfahren zum erschaffen von proteinkinase-inhibitoren |
| PT1382339E (pt) * | 1999-12-10 | 2008-02-06 | Pfizer Prod Inc | Composições que contêm derivados de pirrolo[2,3-d]- pirimidina |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| JP3836436B2 (ja) * | 2001-04-27 | 2006-10-25 | 全薬工業株式会社 | 複素環式化合物及びそれを有効成分とする抗腫瘍剤 |
| AR034897A1 (es) * | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| CA2464214C (en) * | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| DK1536827T3 (da) * | 2002-08-14 | 2009-04-20 | Silence Therapeutics Ag | Anvendelse af proteinkinase N-beta |
| JP2006523237A (ja) | 2003-04-03 | 2006-10-12 | セマフォア ファーマシューティカルズ， インコーポレイテッド | Ｐｉ−３キナーゼインヒビタープロドラッグ |
| JP4980715B2 (ja) * | 2003-05-30 | 2012-07-18 | ジェミン エックス ファーマシューティカルズ カナダ インコーポレイテッド | がんまたはウイルス疾患を治療するための三環性複素環化合物、組成物および方法 |
| JP2007524397A (ja) | 2003-07-03 | 2007-08-30 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | Ｓｙｋキナーゼ発現の阻害 |
| PL1761540T3 (pl) | 2004-05-13 | 2017-06-30 | Icos Corporation | Chinazolinony jako inhibitory ludzkiej kinazy 3-fosfatydyloinozytolu delta |
| TW200635899A (en) * | 2004-12-22 | 2006-10-16 | Astrazeneca Ab | Chemical compounds |
| CA2589773A1 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
| CN101115761B (zh) * | 2005-01-19 | 2012-07-18 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物的前药及其应用 |
| PT1888550E (pt) | 2005-05-12 | 2014-09-03 | Abbvie Bahamas Ltd | Promotores de apoptose |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| JP2009505948A (ja) * | 2005-07-11 | 2009-02-12 | デブジェン エヌブイ | キナーゼ阻害剤としてのアミド誘導体 |
| US7402325B2 (en) * | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| CA2618370A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
| ES2513165T3 (es) * | 2005-10-07 | 2014-10-24 | Exelixis, Inc. | Derivados de N-(3-amino-quinoxalin-2-il)-sulfonamida y su uso como inhibidores de la fosfatidilinositol-3-quinasa |
| NZ567851A (en) * | 2005-11-01 | 2011-09-30 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
| TWI630207B (zh) * | 2005-12-13 | 2018-07-21 | 英塞特控股公司 | 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶 |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| MX2008013196A (es) * | 2006-04-12 | 2008-10-22 | Hoffmann La Roche | 5-amido-2-carboxiamida-indoles. |
| KR101533461B1 (ko) * | 2006-04-26 | 2015-07-02 | 에프. 호프만-라 로슈 아게 | Ｐｉ３ｋ저해제로 유용한 티에노［3,2-ｄ］피리미딘 유도체 |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| EA018573B1 (ru) * | 2006-09-22 | 2013-09-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
| CA2668190A1 (en) * | 2006-11-03 | 2008-05-15 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| KR101737753B1 (ko) | 2007-03-12 | 2017-05-18 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| WO2008118802A1 (en) * | 2007-03-23 | 2008-10-02 | Regents Of The University Of Minnesota | Therapeutic compounds |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| JP2010528035A (ja) * | 2007-05-25 | 2010-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節物質およびその使用 |
| PL2288610T3 (pl) * | 2008-03-11 | 2017-12-29 | Incyte Holdings Corporation | Azetydynowe i cyklobutanowe pochodne jako inhibitory jak |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| CA2742568C (en) * | 2008-11-03 | 2017-09-26 | Syntarga B.V. | Novel cc-1065 analogs and their conjugates |
| US9096579B2 (en) * | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| WO2014184235A1 (en) * | 2013-05-15 | 2014-11-20 | Acturum Life Science AB | Benzamide trpa1 antagonists |
| RS60878B1 (sr) * | 2014-04-04 | 2020-11-30 | Iomet Pharma Ltd | Derivati indola za upotrebu u medicini |
| PL3884939T3 (pl) * | 2016-03-09 | 2024-02-26 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| EP4234552A3 (en) | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
-
2017
- 2017-03-08 EP EP23177193.2A patent/EP4234552A3/en active Pending
- 2017-03-08 EP EP17764038.0A patent/EP3426244B1/en active Active
- 2017-03-08 US US16/082,665 patent/US11014882B2/en active Active
- 2017-03-08 ES ES17764038T patent/ES2949357T3/es active Active
- 2017-03-08 PL PL17764038.0T patent/PL3426244T3/pl unknown
- 2017-03-08 WO PCT/US2017/021436 patent/WO2017156179A1/en not_active Ceased
-
2021
- 2021-04-02 US US17/221,514 patent/US11535593B2/en active Active
-
2022
- 2022-11-22 US US17/992,284 patent/US12264132B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11014882B2 (en) | 2021-05-25 |
| EP3426244C0 (en) | 2023-06-07 |
| ES2949357T3 (es) | 2023-09-28 |
| EP4234552A2 (en) | 2023-08-30 |
| US20190071400A1 (en) | 2019-03-07 |
| WO2017156179A1 (en) | 2017-09-14 |
| EP3426244A4 (en) | 2019-11-06 |
| US20220017464A1 (en) | 2022-01-20 |
| US12264132B2 (en) | 2025-04-01 |
| US20230348386A1 (en) | 2023-11-02 |
| EP3426244A1 (en) | 2019-01-16 |
| EP3426244B1 (en) | 2023-06-07 |
| US11535593B2 (en) | 2022-12-27 |
| EP4234552A3 (en) | 2023-10-18 |
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