PL3884939T3 - Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania - Google Patents
Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowaniaInfo
- Publication number
- PL3884939T3 PL3884939T3 PL21167434.6T PL21167434T PL3884939T3 PL 3884939 T3 PL3884939 T3 PL 3884939T3 PL 21167434 T PL21167434 T PL 21167434T PL 3884939 T3 PL3884939 T3 PL 3884939T3
- Authority
- PL
- Poland
- Prior art keywords
- dehydrogenase inhibitors
- phosphoglycerate dehydrogenase
- phosphoglycerate
- inhibitors
- dehydrogenase
- Prior art date
Links
- 108010038555 Phosphoglycerate dehydrogenase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305930P | 2016-03-09 | 2016-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3884939T3 true PL3884939T3 (pl) | 2024-02-26 |
Family
ID=59789738
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL21167434.6T PL3884939T3 (pl) | 2016-03-09 | 2017-03-08 | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| PL17764026T PL3426243T3 (pl) | 2016-03-09 | 2017-03-08 | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17764026T PL3426243T3 (pl) | 2016-03-09 | 2017-03-08 | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10954220B2 (pl) |
| EP (2) | EP3884939B1 (pl) |
| CY (1) | CY1124338T1 (pl) |
| DK (1) | DK3426243T3 (pl) |
| ES (2) | ES2883328T3 (pl) |
| HR (1) | HRP20211220T1 (pl) |
| HU (1) | HUE055197T2 (pl) |
| LT (1) | LT3426243T (pl) |
| PL (2) | PL3884939T3 (pl) |
| PT (1) | PT3426243T (pl) |
| RS (1) | RS62271B1 (pl) |
| SI (1) | SI3426243T1 (pl) |
| WO (1) | WO2017156165A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3884939T3 (pl) | 2016-03-09 | 2024-02-26 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| EP4234552A3 (en) | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| WO2019074748A1 (en) | 2017-10-09 | 2019-04-18 | Merck Sharp & Dohme Corp. | NOVEL SUBSTITUTED PHENYL-OXETANE AND PHENYLTETRAHYDROFURAN COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO) |
| WO2019099294A1 (en) | 2017-11-14 | 2019-05-23 | Merck Sharp & Dohme Corp. | Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US20240002388A1 (en) * | 2020-08-18 | 2024-01-04 | Hutchison Medipharma Limited | Pyrimidinone compounds and uses thereof |
| JP2024522718A (ja) | 2021-06-16 | 2024-06-21 | セルジーン コーポレーション | 神経変性疾患の治療のための、カルボン酸基を含むアゼチジニル化合物 |
| EP4637755A1 (en) | 2022-12-19 | 2025-10-29 | Chiesi Farmaceutici S.p.A. | Phosphoglicerate dehydrogenase inhibitors for the treatment of fibrosis |
| WO2025125295A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Thieno-indole amide derivatives as phgdh inhibitors |
| WO2025125293A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Thienopyrimidylamine derivatives as phgdh inhibitors |
| WO2025125290A1 (en) | 2023-12-13 | 2025-06-19 | Chiesi Farmaceutici S.P.A. | Novel phosphoglicerate dehydrogenase inhibitors for the treatment of fibrosis |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US5639600A (en) | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| DE60045474D1 (de) | 1999-01-13 | 2011-02-17 | Univ New York State Res Found | Neues verfahren zum erschaffen von proteinkinase-inhibitoren |
| PT1382339E (pt) | 1999-12-10 | 2008-02-06 | Pfizer Prod Inc | Composições que contêm derivados de pirrolo[2,3-d]- pirimidina |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| JP3836436B2 (ja) | 2001-04-27 | 2006-10-25 | 全薬工業株式会社 | 複素環式化合物及びそれを有効成分とする抗腫瘍剤 |
| AR034897A1 (es) | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| CA2464214C (en) | 2001-10-22 | 2011-02-08 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| DK1536827T3 (da) | 2002-08-14 | 2009-04-20 | Silence Therapeutics Ag | Anvendelse af proteinkinase N-beta |
| JP2006523237A (ja) | 2003-04-03 | 2006-10-12 | セマフォア ファーマシューティカルズ， インコーポレイテッド | Ｐｉ−３キナーゼインヒビタープロドラッグ |
| JP4980715B2 (ja) | 2003-05-30 | 2012-07-18 | ジェミン エックス ファーマシューティカルズ カナダ インコーポレイテッド | がんまたはウイルス疾患を治療するための三環性複素環化合物、組成物および方法 |
| JP2007524397A (ja) | 2003-07-03 | 2007-08-30 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | Ｓｙｋキナーゼ発現の阻害 |
| PL1761540T3 (pl) | 2004-05-13 | 2017-06-30 | Icos Corporation | Chinazolinony jako inhibitory ludzkiej kinazy 3-fosfatydyloinozytolu delta |
| TW200635899A (en) | 2004-12-22 | 2006-10-16 | Astrazeneca Ab | Chemical compounds |
| CA2589773A1 (en) | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
| CN101115761B (zh) | 2005-01-19 | 2012-07-18 | 里格尔药品股份有限公司 | 2,4-嘧啶二胺化合物的前药及其应用 |
| PT1888550E (pt) | 2005-05-12 | 2014-09-03 | Abbvie Bahamas Ltd | Promotores de apoptose |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| CA2618370A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
| ES2513165T3 (es) | 2005-10-07 | 2014-10-24 | Exelixis, Inc. | Derivados de N-(3-amino-quinoxalin-2-il)-sulfonamida y su uso como inhibidores de la fosfatidilinositol-3-quinasa |
| NZ567851A (en) | 2005-11-01 | 2011-09-30 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
| TWI630207B (zh) | 2005-12-13 | 2018-07-21 | 英塞特控股公司 | 作為傑納斯激酶（ＪＡＮＵＳ ＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶 |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| KR101533461B1 (ko) | 2006-04-26 | 2015-07-02 | 에프. 호프만-라 로슈 아게 | Ｐｉ３ｋ저해제로 유용한 티에노［3,2-ｄ］피리미딘 유도체 |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| EA018573B1 (ru) | 2006-09-22 | 2013-09-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
| CA2668190A1 (en) | 2006-11-03 | 2008-05-15 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| KR101737753B1 (ko) | 2007-03-12 | 2017-05-18 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| WO2008118802A1 (en) | 2007-03-23 | 2008-10-02 | Regents Of The University Of Minnesota | Therapeutic compounds |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| JP2010528035A (ja) | 2007-05-25 | 2010-08-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節物質およびその使用 |
| PL2288610T3 (pl) | 2008-03-11 | 2017-12-29 | Incyte Holdings Corporation | Azetydynowe i cyklobutanowe pochodne jako inhibitory jak |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| CA2742568C (en) | 2008-11-03 | 2017-09-26 | Syntarga B.V. | Novel cc-1065 analogs and their conjugates |
| US9096579B2 (en) * | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| RS60878B1 (sr) * | 2014-04-04 | 2020-11-30 | Iomet Pharma Ltd | Derivati indola za upotrebu u medicini |
| EP4234552A3 (en) | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| PL3884939T3 (pl) | 2016-03-09 | 2024-02-26 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
-
2017
- 2017-03-08 PL PL21167434.6T patent/PL3884939T3/pl unknown
- 2017-03-08 LT LTEP17764026.5T patent/LT3426243T/lt unknown
- 2017-03-08 RS RS20211023A patent/RS62271B1/sr unknown
- 2017-03-08 ES ES17764026T patent/ES2883328T3/es active Active
- 2017-03-08 HR HRP20211220TT patent/HRP20211220T1/hr unknown
- 2017-03-08 EP EP21167434.6A patent/EP3884939B1/en active Active
- 2017-03-08 ES ES21167434T patent/ES2965264T3/es active Active
- 2017-03-08 PL PL17764026T patent/PL3426243T3/pl unknown
- 2017-03-08 WO PCT/US2017/021420 patent/WO2017156165A1/en not_active Ceased
- 2017-03-08 HU HUE17764026A patent/HUE055197T2/hu unknown
- 2017-03-08 DK DK17764026.5T patent/DK3426243T3/da active
- 2017-03-08 US US16/082,659 patent/US10954220B2/en active Active
- 2017-03-08 PT PT177640265T patent/PT3426243T/pt unknown
- 2017-03-08 SI SI201730882T patent/SI3426243T1/sl unknown
- 2017-03-08 EP EP17764026.5A patent/EP3426243B1/en active Active
-
2021
- 2021-01-15 US US17/150,669 patent/US11634412B2/en active Active
- 2021-07-19 CY CY20211100651T patent/CY1124338T1/el unknown
-
2023
- 2023-03-01 US US18/115,942 patent/US20230312536A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3426243A4 (en) | 2019-07-03 |
| US20190071431A1 (en) | 2019-03-07 |
| EP3884939C0 (en) | 2023-10-25 |
| ES2883328T3 (es) | 2021-12-07 |
| CY1124338T1 (el) | 2022-07-22 |
| PL3426243T3 (pl) | 2021-10-04 |
| EP3884939A1 (en) | 2021-09-29 |
| RS62271B1 (sr) | 2021-09-30 |
| DK3426243T3 (da) | 2021-07-19 |
| EP3426243A1 (en) | 2019-01-16 |
| PT3426243T (pt) | 2021-08-19 |
| HUE055197T2 (hu) | 2021-11-29 |
| WO2017156165A1 (en) | 2017-09-14 |
| LT3426243T (lt) | 2021-08-10 |
| US20230312536A1 (en) | 2023-10-05 |
| SI3426243T1 (sl) | 2021-11-30 |
| HRP20211220T1 (hr) | 2021-10-29 |
| US10954220B2 (en) | 2021-03-23 |
| US20230009122A1 (en) | 2023-01-12 |
| EP3884939B1 (en) | 2023-10-25 |
| ES2965264T3 (es) | 2024-04-11 |
| US11634412B2 (en) | 2023-04-25 |
| EP3426243B1 (en) | 2021-05-19 |
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