SI3426243T1 - Zaviralci 3-fosfoglicerat dehidrogenaze in uporabe le-teh - Google Patents
Zaviralci 3-fosfoglicerat dehidrogenaze in uporabe le-tehInfo
- Publication number
- SI3426243T1 SI3426243T1 SI201730882T SI201730882T SI3426243T1 SI 3426243 T1 SI3426243 T1 SI 3426243T1 SI 201730882 T SI201730882 T SI 201730882T SI 201730882 T SI201730882 T SI 201730882T SI 3426243 T1 SI3426243 T1 SI 3426243T1
- Authority
- SI
- Slovenia
- Prior art keywords
- dehydrogenase inhibitors
- phosphoglycerate dehydrogenase
- phosphoglycerate
- inhibitors
- dehydrogenase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305930P | 2016-03-09 | 2016-03-09 | |
| PCT/US2017/021420 WO2017156165A1 (en) | 2016-03-09 | 2017-03-08 | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| EP17764026.5A EP3426243B1 (en) | 2016-03-09 | 2017-03-08 | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3426243T1 true SI3426243T1 (sl) | 2021-11-30 |
Family
ID=59789738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201730882T SI3426243T1 (sl) | 2016-03-09 | 2017-03-08 | Zaviralci 3-fosfoglicerat dehidrogenaze in uporabe le-teh |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10954220B2 (sl) |
| EP (2) | EP3884939B1 (sl) |
| CY (1) | CY1124338T1 (sl) |
| DK (1) | DK3426243T3 (sl) |
| ES (2) | ES2883328T3 (sl) |
| HR (1) | HRP20211220T1 (sl) |
| HU (1) | HUE055197T2 (sl) |
| LT (1) | LT3426243T (sl) |
| PL (2) | PL3884939T3 (sl) |
| PT (1) | PT3426243T (sl) |
| RS (1) | RS62271B1 (sl) |
| SI (1) | SI3426243T1 (sl) |
| WO (1) | WO2017156165A1 (sl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3426244T3 (pl) * | 2016-03-09 | 2023-09-25 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
| EP3884939B1 (en) | 2016-03-09 | 2023-10-25 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| EP3694506B1 (en) * | 2017-10-09 | 2023-08-02 | Merck Sharp & Dohme LLC | Novel substituted phenyloxetane and phenyltetrahydrofuran compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| US11498904B2 (en) | 2017-11-14 | 2022-11-15 | Merck Sharp & Dohme Llc | Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| IL300471A (en) * | 2020-08-18 | 2023-04-01 | Hutchison Medipharma Ltd | Pyrimidinone compounds and their uses |
| US11919879B2 (en) | 2021-06-16 | 2024-03-05 | Celgene Corporation | Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US5639600A (en) | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| MXPA01007099A (es) | 1999-01-13 | 2002-03-27 | Univ New York State Res Found | Metodo novedoso para disenar inhibidores de la proteina cinasa. |
| CZ303875B6 (cs) | 1999-12-10 | 2013-06-05 | Pfizer Products Inc. | Pyrrolo[2,3-d]pyrimidinová sloucenina a farmaceutická kompozice s jejím obsahem |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| KR100833371B1 (ko) | 2001-04-27 | 2008-05-28 | 젠야쿠코교가부시키가이샤 | 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제 |
| AR034897A1 (es) | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
| MXPA04003758A (es) | 2001-10-22 | 2005-06-20 | Univ New York State Res Found | Inhibidores de proteina - cinasas y proteina-fosfatasas, metodos para disenarlos y metodos para usarlos. |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| EP1536827B1 (en) | 2002-08-14 | 2009-01-07 | Silence Therapeutics Aktiengesellschaft | Use of protein kinase n beta |
| EP1611119A1 (en) | 2003-04-03 | 2006-01-04 | Semafore Pharmaceuticals, Inc. | Pi-3 kinase inhibitor prodrugs |
| AU2004242928B2 (en) | 2003-05-30 | 2011-03-10 | Gemin X Pharmaceuticals Canada Inc. | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
| AU2004257167B2 (en) | 2003-07-03 | 2012-03-29 | The Trustees Of The University Of Pennsylvania | Inhibition of Syk kinase expression |
| EP1761540B1 (en) | 2004-05-13 | 2016-09-28 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| AR053992A1 (es) | 2004-12-22 | 2007-05-30 | Astrazeneca Ab | Compuestos quimicos con actividad anticancerosa, un procedimiento para su preparacion, su uso en la preparacion de medicamentos y composicion farmaceutica. |
| AR054183A1 (es) | 2004-12-22 | 2007-06-06 | Astrazeneca Ab | Derivados de piridincarboxamida y su uso como agentes anticancerigenos. procesos de obtencion y composiciones farmaceuticas. |
| US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| TWI337608B (en) | 2005-05-12 | 2011-02-21 | Abbott Lab | Apoptosis promoters |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| AU2006278505B2 (en) | 2005-08-04 | 2013-01-17 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| EA019255B1 (ru) | 2005-10-07 | 2014-02-28 | Экселиксис, Инк. | Ингибиторы фосфатидилинозит-3-киназы и содержащие их фармацевтические композиции |
| JP5191391B2 (ja) | 2005-11-01 | 2013-05-08 | ターゲジェン インコーポレーティッド | キナーゼのビ−アリールメタ−ピリミジン阻害剤 |
| CN103214484B (zh) | 2005-12-13 | 2016-07-06 | 因塞特控股公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| US7781433B2 (en) | 2006-04-26 | 2010-08-24 | Piramed Limited | Pharmaceutical compounds |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| SI2526934T1 (sl) | 2006-09-22 | 2016-04-29 | Pharmacyclics Llc | Inhibitorji Bruton tirozin kinaze |
| US20100048539A1 (en) | 2006-11-03 | 2010-02-25 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| KR101566840B1 (ko) | 2007-03-12 | 2015-11-06 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| WO2008118802A1 (en) | 2007-03-23 | 2008-10-02 | Regents Of The University Of Minnesota | Therapeutic compounds |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| NZ581309A (en) | 2007-05-25 | 2012-02-24 | Vertex Pharma | Ion channel modulators and methods of use |
| SI2288610T1 (sl) | 2008-03-11 | 2016-11-30 | Incyte Holdings Corporation | Derivati azetidina in ciklobutana kot inhibitorji jak |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| NO2344478T3 (sl) | 2008-11-03 | 2018-02-24 | ||
| US9096579B2 (en) * | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| UA121386C2 (uk) * | 2014-04-04 | 2020-05-25 | Айомет Фарма Лтд | Похідні індолу, фармацевтична композиція, яка їх містить, та способи їх застосування |
| EP3884939B1 (en) | 2016-03-09 | 2023-10-25 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| PL3426244T3 (pl) | 2016-03-09 | 2023-09-25 | Raze Therapeutics, Inc. | Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania |
-
2017
- 2017-03-08 EP EP21167434.6A patent/EP3884939B1/en active Active
- 2017-03-08 SI SI201730882T patent/SI3426243T1/sl unknown
- 2017-03-08 EP EP17764026.5A patent/EP3426243B1/en active Active
- 2017-03-08 PL PL21167434.6T patent/PL3884939T3/pl unknown
- 2017-03-08 PT PT177640265T patent/PT3426243T/pt unknown
- 2017-03-08 HU HUE17764026A patent/HUE055197T2/hu unknown
- 2017-03-08 LT LTEP17764026.5T patent/LT3426243T/lt unknown
- 2017-03-08 ES ES17764026T patent/ES2883328T3/es active Active
- 2017-03-08 PL PL17764026T patent/PL3426243T3/pl unknown
- 2017-03-08 RS RS20211023A patent/RS62271B1/sr unknown
- 2017-03-08 DK DK17764026.5T patent/DK3426243T3/da active
- 2017-03-08 US US16/082,659 patent/US10954220B2/en active Active
- 2017-03-08 ES ES21167434T patent/ES2965264T3/es active Active
- 2017-03-08 WO PCT/US2017/021420 patent/WO2017156165A1/en active Application Filing
-
2021
- 2021-01-15 US US17/150,669 patent/US11634412B2/en active Active
- 2021-07-19 CY CY20211100651T patent/CY1124338T1/el unknown
- 2021-07-28 HR HRP20211220TT patent/HRP20211220T1/hr unknown
-
2023
- 2023-03-01 US US18/115,942 patent/US20230312536A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3426243A1 (en) | 2019-01-16 |
| EP3426243A4 (en) | 2019-07-03 |
| LT3426243T (lt) | 2021-08-10 |
| HUE055197T2 (hu) | 2021-11-29 |
| EP3884939A1 (en) | 2021-09-29 |
| PL3884939T3 (pl) | 2024-02-26 |
| US20230312536A1 (en) | 2023-10-05 |
| EP3884939C0 (en) | 2023-10-25 |
| WO2017156165A1 (en) | 2017-09-14 |
| PT3426243T (pt) | 2021-08-19 |
| RS62271B1 (sr) | 2021-09-30 |
| HRP20211220T1 (hr) | 2021-10-29 |
| EP3426243B1 (en) | 2021-05-19 |
| US20190071431A1 (en) | 2019-03-07 |
| ES2883328T3 (es) | 2021-12-07 |
| EP3884939B1 (en) | 2023-10-25 |
| US11634412B2 (en) | 2023-04-25 |
| US20230009122A1 (en) | 2023-01-12 |
| DK3426243T3 (da) | 2021-07-19 |
| CY1124338T1 (el) | 2022-07-22 |
| US10954220B2 (en) | 2021-03-23 |
| ES2965264T3 (es) | 2024-04-11 |
| PL3426243T3 (pl) | 2021-10-04 |
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