UA115767C2 - Способи отримання ізохінолінонів і тверді форми ізохінолінонів - Google Patents

Способи отримання ізохінолінонів і тверді форми ізохінолінонів

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Publication number
UA115767C2
UA115767C2 UAA201309964A UAA201309964A UA115767C2 UA 115767 C2 UA115767 C2 UA 115767C2 UA A201309964 A UAA201309964 A UA A201309964A UA A201309964 A UAA201309964 A UA A201309964A UA 115767 C2 UA115767 C2 UA 115767C2
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UA
Ukraine
Prior art keywords
isoquinolinones
processes
preparing
solid forms
kinase activity
Prior art date
Application number
UAA201309964A
Other languages
English (en)
Inventor
Пінда Жень
Майкл Мартін
Пол Ізбестер
Бенджамін С. Лейн
Джейсон КРОПП
Original Assignee
Інфініті Фармасьютікалз, Інк.
ІНТЕЛЛАЙКІН ЕлЕлСі
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46491229&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA115767(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Інфініті Фармасьютікалз, Інк., ІНТЕЛЛАЙКІН ЕлЕлСі filed Critical Інфініті Фармасьютікалз, Інк.
Publication of UA115767C2 publication Critical patent/UA115767C2/uk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

У винаході описані поліморфи хімічних сполук, які модулюють активність кіназ, в т. ч. активність РІ3-кіназ, а також сполуки, фармацевтичні композиції і способи лікування захворювань і станів, пов'язаних з активністю кіназ, в т. ч. активністю РІ3-кіназ. Крім того, винахід стосується способів отримання сполук, їх поліморфів і їх фармацевтичних композицій.
UAA201309964A 2011-01-10 2012-01-10 Способи отримання ізохінолінонів і тверді форми ізохінолінонів UA115767C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161431304P 2011-01-10 2011-01-10
US201161578655P 2011-12-21 2011-12-21
PCT/US2012/020831 WO2012097000A1 (en) 2011-01-10 2012-01-10 Processes for preparing isoquinolinones and solid forms of isoquinolinones

Publications (1)

Publication Number Publication Date
UA115767C2 true UA115767C2 (uk) 2017-12-26

Family

ID=46491229

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201309964A UA115767C2 (uk) 2011-01-10 2012-01-10 Способи отримання ізохінолінонів і тверді форми ізохінолінонів

Country Status (23)

Country Link
US (7) US8809349B2 (uk)
EP (3) EP3581574A1 (uk)
JP (2) JP2014501790A (uk)
KR (2) KR20180080358A (uk)
CN (1) CN103648499B (uk)
AR (1) AR084824A1 (uk)
AU (1) AU2012205669B2 (uk)
BR (1) BR112013017670B1 (uk)
CA (1) CA2824197C (uk)
CL (1) CL2013002007A1 (uk)
DK (1) DK2663309T3 (uk)
ES (1) ES2637113T3 (uk)
HK (1) HK1245110B (uk)
IL (1) IL227387B (uk)
MX (1) MX347708B (uk)
NZ (1) NZ612909A (uk)
PE (2) PE20141303A1 (uk)
PH (1) PH12018500960A1 (uk)
SG (2) SG191897A1 (uk)
TW (3) TWI674262B (uk)
UA (1) UA115767C2 (uk)
WO (1) WO2012097000A1 (uk)
ZA (1) ZA201305150B (uk)

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