ES2721148T3 - Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso - Google Patents

Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso Download PDF

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Publication number
ES2721148T3
ES2721148T3 ES09733078T ES09733078T ES2721148T3 ES 2721148 T3 ES2721148 T3 ES 2721148T3 ES 09733078 T ES09733078 T ES 09733078T ES 09733078 T ES09733078 T ES 09733078T ES 2721148 T3 ES2721148 T3 ES 2721148T3
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Spain
Prior art keywords
paclitaxel
preparation
pharmaceutical compositions
conjugates
related methods
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ES09733078T
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English (en)
Inventor
Michel Demeule
Christian Che
Anthony Regina
Richard Beliveau
Catherine Gagnon
Jean-Paul Castaigne
Reinhard Gabathuler
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Angiochem Inc
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Angiochem Inc
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una composición liofilizada que comprende: (a) ANG1005, en donde ANG1005 tiene la estructura:**Fórmula** (b) un agente de tonicidad opcional; (c) un agente de tamponamiento; (d) un agente de carga; (e) un agente solubilizante, en donde dicho agente solubilizante es un éster de polioxietileno de un ácido graso; y (f) del 0,2 al 10 % de DMSO.
ES09733078T 2008-04-18 2009-04-20 Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso Active ES2721148T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12467708P 2008-04-18 2008-04-18
PCT/CA2009/000542 WO2009127072A1 (en) 2008-04-18 2009-04-20 Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use

Publications (1)

Publication Number Publication Date
ES2721148T3 true ES2721148T3 (es) 2019-07-29

Family

ID=41198750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09733078T Active ES2721148T3 (es) 2008-04-18 2009-04-20 Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso

Country Status (16)

Country Link
US (1) US8710013B2 (es)
EP (1) EP2279008B1 (es)
JP (2) JP5860698B2 (es)
CN (1) CN102026667B (es)
AU (1) AU2009238187B2 (es)
BR (1) BRPI0910557A2 (es)
CA (1) CA2721019C (es)
DK (1) DK2279008T3 (es)
ES (1) ES2721148T3 (es)
MX (1) MX355683B (es)
PL (1) PL2279008T3 (es)
PT (1) PT2279008T (es)
RU (1) RU2518240C2 (es)
TR (1) TR201905480T4 (es)
WO (1) WO2009127072A1 (es)
ZA (1) ZA201007170B (es)

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