MX347708B - Proceso para preparar isoquinolinonas y formas solidas de isoquinolinonas. - Google Patents

Proceso para preparar isoquinolinonas y formas solidas de isoquinolinonas.

Info

Publication number
MX347708B
MX347708B MX2013008065A MX2013008065A MX347708B MX 347708 B MX347708 B MX 347708B MX 2013008065 A MX2013008065 A MX 2013008065A MX 2013008065 A MX2013008065 A MX 2013008065A MX 347708 B MX347708 B MX 347708B
Authority
MX
Mexico
Prior art keywords
isoquinolinones
processes
preparing
solid forms
kinase activity
Prior art date
Application number
MX2013008065A
Other languages
English (en)
Other versions
MX2013008065A (es
Inventor
Isbester Paul
Martin Michael
Ren Pingda
s lane Benjamin
Kropp Jason
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46491229&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347708(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of MX2013008065A publication Critical patent/MX2013008065A/es
Publication of MX347708B publication Critical patent/MX347708B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen en la presente los polimorfos de los compuestos químicos que modulan la actividad cinasa, incluyendo actividad de PI 3 cinasa, y compuestos, composiciones farmacéuticas y métodos de tratamiento de enfermedades y estados asociados con la actividad cinasa, incluyendo actividad PI 3 cinasa. También se proporcionan en el presente documento procedimientos para preparar compuestos, polimorfos de los mismos y composiciones farmacéuticas de los mismos.
MX2013008065A 2011-01-10 2012-01-10 Proceso para preparar isoquinolinonas y formas solidas de isoquinolinonas. MX347708B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161431304P 2011-01-10 2011-01-10
US201161578655P 2011-12-21 2011-12-21
PCT/US2012/020831 WO2012097000A1 (en) 2011-01-10 2012-01-10 Processes for preparing isoquinolinones and solid forms of isoquinolinones

Publications (2)

Publication Number Publication Date
MX2013008065A MX2013008065A (es) 2014-01-31
MX347708B true MX347708B (es) 2017-05-09

Family

ID=46491229

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008065A MX347708B (es) 2011-01-10 2012-01-10 Proceso para preparar isoquinolinonas y formas solidas de isoquinolinonas.

Country Status (23)

Country Link
US (8) US8809349B2 (es)
EP (3) EP2663309B1 (es)
JP (2) JP2014501790A (es)
KR (2) KR20180080358A (es)
CN (1) CN103648499B (es)
AR (1) AR084824A1 (es)
AU (1) AU2012205669B2 (es)
BR (1) BR112013017670B1 (es)
CA (1) CA2824197C (es)
CL (1) CL2013002007A1 (es)
DK (1) DK2663309T3 (es)
ES (1) ES2637113T3 (es)
HK (1) HK1245110B (es)
IL (1) IL227387B (es)
MX (1) MX347708B (es)
NZ (1) NZ612909A (es)
PE (2) PE20141303A1 (es)
PH (2) PH12013501465A1 (es)
SG (2) SG10201600179RA (es)
TW (3) TWI659956B (es)
UA (1) UA115767C2 (es)
WO (1) WO2012097000A1 (es)
ZA (1) ZA201305150B (es)

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