DE69719367T2 - Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe - Google Patents

Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe

Info

Publication number
DE69719367T2
DE69719367T2 DE69719367T DE69719367T DE69719367T2 DE 69719367 T2 DE69719367 T2 DE 69719367T2 DE 69719367 T DE69719367 T DE 69719367T DE 69719367 T DE69719367 T DE 69719367T DE 69719367 T2 DE69719367 T2 DE 69719367T2
Authority
DE
Germany
Prior art keywords
producing
composition
organic solvent
physiologically active
active polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69719367T
Other languages
English (en)
Other versions
DE69719367D1 (de
Inventor
Yutaka Yamagata
Masafumi Misaki
Susumu Iwasa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69719367D1 publication Critical patent/DE69719367D1/de
Application granted granted Critical
Publication of DE69719367T2 publication Critical patent/DE69719367T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
DE69719367T 1996-12-20 1997-12-18 Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe Expired - Lifetime DE69719367T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34204696 1996-12-20
PCT/JP1997/004671 WO1998027980A2 (en) 1996-12-20 1997-12-18 Method of producing a sustained-release preparation

Publications (2)

Publication Number Publication Date
DE69719367D1 DE69719367D1 (de) 2003-04-03
DE69719367T2 true DE69719367T2 (de) 2003-10-16

Family

ID=18350747

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719367T Expired - Lifetime DE69719367T2 (de) 1996-12-20 1997-12-18 Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe

Country Status (10)

Country Link
US (2) US6197350B1 (de)
EP (1) EP0946169B1 (de)
KR (1) KR20000057693A (de)
AT (1) ATE233088T1 (de)
AU (1) AU7871298A (de)
CA (1) CA2275422A1 (de)
DE (1) DE69719367T2 (de)
DK (1) DK0946169T3 (de)
WO (1) WO1998027980A2 (de)
ZA (1) ZA9711385B (de)

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AU7871298A (en) 1998-07-17
US6399103B1 (en) 2002-06-04
EP0946169A2 (de) 1999-10-06
ZA9711385B (en) 1999-06-18
US6197350B1 (en) 2001-03-06
EP0946169B1 (de) 2003-02-26
DE69719367D1 (de) 2003-04-03
CA2275422A1 (en) 1998-07-02
KR20000057693A (ko) 2000-09-25
DK0946169T3 (da) 2003-04-22
ATE233088T1 (de) 2003-03-15
WO1998027980A2 (en) 1998-07-02

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