HRP20110713T1 - Postupci liječenja kroničnog virusnog hepatitisa c uz upotrebu ro 113-0830 - Google Patents

Postupci liječenja kroničnog virusnog hepatitisa c uz upotrebu ro 113-0830 Download PDF

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Publication number
HRP20110713T1
HRP20110713T1 HR20110713T HRP20110713T HRP20110713T1 HR P20110713 T1 HRP20110713 T1 HR P20110713T1 HR 20110713 T HR20110713 T HR 20110713T HR P20110713 T HRP20110713 T HR P20110713T HR P20110713 T1 HRP20110713 T1 HR P20110713T1
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Croatia
Prior art keywords
inhibitor
intended
matrix metalloproteinases
hepatitis
accordance
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HR20110713T
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English (en)
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P. Spada Alfred
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Conatus Pharmaceuticals
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Publication of HRP20110713T1 publication Critical patent/HRP20110713T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Inhibitor matričnih metaloproteinaza namijenjen upotrebi u liječenju kroničnog virusnog hepatitisa C, naznačen time što inhibitor matričnih metaloproteinaza je: Patent sadrži još 6 patentnih zahtjeva.

Claims (7)

1. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u liječenju kroničnog virusnog hepatitisa C, naznačen time što inhibitor matričnih metaloproteinaza je: [image]
2. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što inhibitor matričnih metaloproteinaza se pripravlja za primjenu na pacijentu koji prethodno liječenom drugim lijekom za bolest jetre, ili koji je istodobno liječen drugim lijekom za bolest jetre.
3. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što inhibitor matričnih metaloproteinaza je namijenjen upotrebi kod smanjivanja oštećenja jetre uzrokovano kroničnim virusnim hepatitisom C.
4. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što inhibitor matričnih metaloproteinaza je namijenjen upotrebi kod inhibiranja replikacije virusa hepatitisa C u stanici inficiranoj virusom hepatitisa C.
5. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što inhibitor matričnih metaloproteinaza je namijenjen upotrebi kod inhibiranja replikacije virusa hepatitisa C kod pacijenta inficiranog virusom hepatitisa C.
6. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačen time što inhibitor matričnih metaloproteinaza se pripravlja za primjenu uz drugo sredstvo.
7. Inhibitor matričnih metaloproteinaza namijenjen upotrebi u skladu s patentnim zahtjevom 6, naznačen time što drugo sredstvo se bira između interferona protiv virusa hepatitisa C, ribavirina ili njihove kombinacije.
HR20110713T 2007-02-28 2011-10-05 Postupci liječenja kroničnog virusnog hepatitisa c uz upotrebu ro 113-0830 HRP20110713T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90432207P 2007-02-28 2007-02-28
US93730107P 2007-06-26 2007-06-26
PCT/US2008/002591 WO2008106166A2 (en) 2007-02-28 2008-02-27 Methods for the treatment of liver diseases using specified matrix metalloproteinase (mmp) inhibitors

Publications (1)

Publication Number Publication Date
HRP20110713T1 true HRP20110713T1 (hr) 2011-11-30

Family

ID=39493125

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110713T HRP20110713T1 (hr) 2007-02-28 2011-10-05 Postupci liječenja kroničnog virusnog hepatitisa c uz upotrebu ro 113-0830

Country Status (12)

Country Link
US (1) US20080207569A1 (hr)
EP (1) EP2144604B1 (hr)
JP (1) JP2010520200A (hr)
AT (1) ATE525068T1 (hr)
AU (1) AU2008219622A1 (hr)
BR (1) BRPI0808089A2 (hr)
CA (1) CA2696053A1 (hr)
DK (1) DK2144604T3 (hr)
HR (1) HRP20110713T1 (hr)
PL (1) PL2144604T3 (hr)
PT (1) PT2144604E (hr)
WO (1) WO2008106166A2 (hr)

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US20080207569A1 (en) 2008-08-28
PL2144604T3 (pl) 2012-02-29
BRPI0808089A2 (pt) 2014-07-15
EP2144604A2 (en) 2010-01-20
PT2144604E (pt) 2011-10-19
AU2008219622A1 (en) 2008-09-04
WO2008106166A3 (en) 2008-10-30
CA2696053A1 (en) 2008-09-04
ATE525068T1 (de) 2011-10-15
DK2144604T3 (da) 2011-10-17

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