EA201200096A1 - Фармацевтическая композиция ингибитора протеазы вируса гепатита c - Google Patents
Фармацевтическая композиция ингибитора протеазы вируса гепатита cInfo
- Publication number
- EA201200096A1 EA201200096A1 EA201200096A EA201200096A EA201200096A1 EA 201200096 A1 EA201200096 A1 EA 201200096A1 EA 201200096 A EA201200096 A EA 201200096A EA 201200096 A EA201200096 A EA 201200096A EA 201200096 A1 EA201200096 A1 EA 201200096A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- inhibitor
- hypatitis
- virus protease
- protease inhibitor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
В заявке описана фармацевтическая композиция ингибитора протеазы вируса гепатита С, которую можно использовать для орального введения в виде капсулы, заполненной жидкостью или полутвердым веществом, способы применения этой композиции для ингибирования репликации вируса гепатита С (HCV) и лечения инфекции, вызываемой HCV. Жидкая или полутвердая фармацевтическая композиция, предлагаемая в настоящем изобретении, содержит соединение формулы I или его фармацевтически приемлемую соль в сочетании с одним или несколькими фармацевтически приемлемыми липидами и гидрофильными поверхностно-активными веществами.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22350709P | 2009-07-07 | 2009-07-07 | |
PCT/US2010/040734 WO2011005646A2 (en) | 2009-07-07 | 2010-07-01 | Pharmaceutical composition for a hepatitis c viral protease inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201200096A1 true EA201200096A1 (ru) | 2012-08-30 |
EA023433B1 EA023433B1 (ru) | 2016-06-30 |
Family
ID=43245003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201200096A EA023433B1 (ru) | 2009-07-07 | 2010-07-01 | Фармацевтическая композиция ингибитора протеазы вируса гепатита c |
Country Status (35)
Country | Link |
---|---|
US (1) | US9034831B2 (ru) |
EP (1) | EP2451438B8 (ru) |
JP (1) | JP5607736B2 (ru) |
KR (1) | KR101685941B1 (ru) |
CN (1) | CN102470103B (ru) |
AP (1) | AP2011005979A0 (ru) |
AR (1) | AR077393A1 (ru) |
AU (1) | AU2010270783B2 (ru) |
BR (1) | BR112012000287B8 (ru) |
CA (1) | CA2767692C (ru) |
CL (1) | CL2012000054A1 (ru) |
CO (1) | CO6480980A2 (ru) |
DK (1) | DK2451438T3 (ru) |
EA (1) | EA023433B1 (ru) |
EC (1) | ECSP12011624A (ru) |
ES (1) | ES2464367T3 (ru) |
GE (1) | GEP20146016B (ru) |
HR (1) | HRP20140445T1 (ru) |
IL (1) | IL216098A (ru) |
MA (1) | MA33491B1 (ru) |
ME (1) | ME01718B (ru) |
MX (1) | MX2011013824A (ru) |
MY (1) | MY154683A (ru) |
NZ (1) | NZ596928A (ru) |
PE (1) | PE20120322A1 (ru) |
PL (1) | PL2451438T3 (ru) |
PT (1) | PT2451438E (ru) |
RS (1) | RS53209B (ru) |
SG (1) | SG177569A1 (ru) |
SI (1) | SI2451438T1 (ru) |
TN (1) | TN2012000009A1 (ru) |
TW (1) | TWI490216B (ru) |
UA (1) | UA104195C2 (ru) |
UY (1) | UY32760A (ru) |
WO (1) | WO2011005646A2 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11926642B2 (en) | 2020-04-05 | 2024-03-12 | Pfizer Inc. | Compounds and methods for the treatment of COVID-19 |
Families Citing this family (25)
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UA103496C2 (ru) * | 2008-09-17 | 2013-10-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Комбинация ингибитора протеазы ns3 hcv с интерфероном и рибавирином |
PT2451438E (pt) | 2009-07-07 | 2014-03-26 | Boehringer Ingelheim Int | Composição farmacêutica para um inibidor de protease viral da hepatite c |
EP2493470A1 (en) | 2009-10-30 | 2012-09-05 | Boehringer Ingelheim International GmbH | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
JP2013540112A (ja) | 2010-09-30 | 2013-10-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Hcv感染を治療するための併用療法 |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
ES2572328B1 (es) | 2011-10-21 | 2017-08-24 | Abbvie Inc. | Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para su uso en el tratamiento del vhc |
DE202012012954U1 (de) | 2011-10-21 | 2014-08-12 | Abbvie Inc. | Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV |
SG11201404042VA (en) | 2012-01-12 | 2014-08-28 | Boehringer Ingelheim Int | Stabilized pharmaceutical formulations of a potent hcv inhibitor |
WO2013137869A1 (en) | 2012-03-14 | 2013-09-19 | Boehringer Ingelheim International Gmbh | Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population |
WO2013147749A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient subgenotype populations |
WO2013147750A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
JP2015512900A (ja) | 2012-03-28 | 2015-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法 |
JP6154474B2 (ja) | 2012-10-19 | 2017-06-28 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎ウイルス阻害剤 |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9580463B2 (en) | 2013-03-07 | 2017-02-28 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2014138374A1 (en) | 2013-03-08 | 2014-09-12 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
EA032322B1 (ru) * | 2013-03-15 | 2019-05-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Твердая пероральная дозированная композиция ингибитора hcv в аморфном состоянии |
EP2899207A1 (en) | 2014-01-28 | 2015-07-29 | Amikana.Biologics | New method for testing HCV protease inhibition |
CN109689063A (zh) | 2016-04-28 | 2019-04-26 | 埃默里大学 | 含有炔烃的核苷酸和核苷治疗组合物及其相关用途 |
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DK2331538T3 (da) | 2008-09-16 | 2014-06-02 | Boehringer Ingelheim Int | Krystallinske former af en 2-thiazolyl-4-quinolinyl-oxy-derivat, en potent HCV-inhibitor |
MY155402A (en) | 2008-11-21 | 2015-10-15 | Boehringer Ingelheim Int | Pharmaceutical composition of a potent hcv inhibitor for oral administration |
PT2451438E (pt) | 2009-07-07 | 2014-03-26 | Boehringer Ingelheim Int | Composição farmacêutica para um inibidor de protease viral da hepatite c |
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2010
- 2010-07-01 PT PT107316853T patent/PT2451438E/pt unknown
- 2010-07-01 SG SG2012001368A patent/SG177569A1/en unknown
- 2010-07-01 CN CN201080030433.1A patent/CN102470103B/zh not_active Expired - Fee Related
- 2010-07-01 MX MX2011013824A patent/MX2011013824A/es active IP Right Grant
- 2010-07-01 AP AP2011005979A patent/AP2011005979A0/xx unknown
- 2010-07-01 UA UAA201201066A patent/UA104195C2/ru unknown
- 2010-07-01 KR KR1020127000354A patent/KR101685941B1/ko active IP Right Grant
- 2010-07-01 DK DK10731685.3T patent/DK2451438T3/da active
- 2010-07-01 JP JP2012519597A patent/JP5607736B2/ja not_active Expired - Fee Related
- 2010-07-01 PL PL10731685T patent/PL2451438T3/pl unknown
- 2010-07-01 RS RS20140116A patent/RS53209B/en unknown
- 2010-07-01 PE PE2011002086A patent/PE20120322A1/es active IP Right Grant
- 2010-07-01 EA EA201200096A patent/EA023433B1/ru not_active IP Right Cessation
- 2010-07-01 MA MA34511A patent/MA33491B1/fr unknown
- 2010-07-01 ES ES10731685.3T patent/ES2464367T3/es active Active
- 2010-07-01 AU AU2010270783A patent/AU2010270783B2/en not_active Ceased
- 2010-07-01 EP EP10731685.3A patent/EP2451438B8/en active Active
- 2010-07-01 MY MYPI2012000028A patent/MY154683A/en unknown
- 2010-07-01 BR BR112012000287A patent/BR112012000287B8/pt not_active IP Right Cessation
- 2010-07-01 CA CA2767692A patent/CA2767692C/en not_active Expired - Fee Related
- 2010-07-01 GE GEAP201012562A patent/GEP20146016B/en unknown
- 2010-07-01 ME MEP-2014-23A patent/ME01718B/me unknown
- 2010-07-01 SI SI201030565T patent/SI2451438T1/sl unknown
- 2010-07-01 NZ NZ596928A patent/NZ596928A/xx not_active IP Right Cessation
- 2010-07-01 WO PCT/US2010/040734 patent/WO2011005646A2/en active Application Filing
- 2010-07-05 UY UY0001032760A patent/UY32760A/es not_active Application Discontinuation
- 2010-07-06 US US12/830,771 patent/US9034831B2/en active Active
- 2010-07-06 AR ARP100102427A patent/AR077393A1/es not_active Application Discontinuation
- 2010-07-06 TW TW099122196A patent/TWI490216B/zh not_active IP Right Cessation
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2011
- 2011-11-02 IL IL216098A patent/IL216098A/en active IP Right Grant
- 2011-12-29 CO CO11181070A patent/CO6480980A2/es not_active Application Discontinuation
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2012
- 2012-01-05 TN TNP2012000009A patent/TN2012000009A1/en unknown
- 2012-01-06 CL CL2012000054A patent/CL2012000054A1/es unknown
- 2012-01-26 EC EC2012011624A patent/ECSP12011624A/es unknown
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2014
- 2014-05-19 HR HRP20140445AT patent/HRP20140445T1/hr unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11926642B2 (en) | 2020-04-05 | 2024-03-12 | Pfizer Inc. | Compounds and methods for the treatment of COVID-19 |
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