AR077393A1 - Composicion farmaceutica para un inhibidor de proteasa del virus de la hepatitis c - Google Patents

Composicion farmaceutica para un inhibidor de proteasa del virus de la hepatitis c

Info

Publication number
AR077393A1
AR077393A1 ARP100102427A ARP100102427A AR077393A1 AR 077393 A1 AR077393 A1 AR 077393A1 AR P100102427 A ARP100102427 A AR P100102427A AR P100102427 A ARP100102427 A AR P100102427A AR 077393 A1 AR077393 A1 AR 077393A1
Authority
AR
Argentina
Prior art keywords
pharmaceutically acceptable
pharmaceutical composition
composition according
fatty acids
polyethoxylated
Prior art date
Application number
ARP100102427A
Other languages
English (en)
Inventor
John Fen-Jing Chen
Robert J Richard Schwabe
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR077393A1 publication Critical patent/AR077393A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicacion 1: Una composicion farmacéutica líquida, caracterizada porque comprende: (a) un compuesto de formula (1) o una sal farmacéuticamente aceptable del mismo; (b) uno o más lípidos farmacéuticamente aceptables; y (c) uno o más tensioactivos hidrofilos farmacéuticamente aceptables. Reivindicacion 5: Una composicion farmacéutica de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizada porque el lípido farmacéuticamente aceptable se selecciona entre: ácidos grasos, mono-, di- o triglicéridos de cadena media o larga, ésteres de ácidos grasos de propilenglicol, ésteres de ácidos grasos de sorbitol, vitaminas insolubles en agua, y mezclas de los mismos. Reivindicacion 7: Una composicion farmacéutica de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizada porque el tensioactivo hidrofilo farmacéuticamente aceptable se selecciona entre aceites vegetales polietoxilados, tocoferoles polietoxilados, ésteres de ácidos grasos de sorbitol polietoxilados, sales biliares, lecitinas y mezclas de los mismos. Reivindicacion 8: Una composicion farmacéutica de acuerdo con cualquiera de las reivindicaciones anteriores, caracterizada porque comprende además un disolvente hidrofilo farmacéuticamente aceptable.
ARP100102427A 2009-07-07 2010-07-06 Composicion farmaceutica para un inhibidor de proteasa del virus de la hepatitis c AR077393A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22350709P 2009-07-07 2009-07-07

Publications (1)

Publication Number Publication Date
AR077393A1 true AR077393A1 (es) 2011-08-24

Family

ID=43245003

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102427A AR077393A1 (es) 2009-07-07 2010-07-06 Composicion farmaceutica para un inhibidor de proteasa del virus de la hepatitis c

Country Status (35)

Country Link
US (1) US9034831B2 (es)
EP (1) EP2451438B8 (es)
JP (1) JP5607736B2 (es)
KR (1) KR101685941B1 (es)
CN (1) CN102470103B (es)
AP (1) AP2011005979A0 (es)
AR (1) AR077393A1 (es)
AU (1) AU2010270783B2 (es)
BR (1) BR112012000287B8 (es)
CA (1) CA2767692C (es)
CL (1) CL2012000054A1 (es)
CO (1) CO6480980A2 (es)
DK (1) DK2451438T3 (es)
EA (1) EA023433B1 (es)
EC (1) ECSP12011624A (es)
ES (1) ES2464367T3 (es)
GE (1) GEP20146016B (es)
HR (1) HRP20140445T1 (es)
IL (1) IL216098A (es)
MA (1) MA33491B1 (es)
ME (1) ME01718B (es)
MX (1) MX2011013824A (es)
MY (1) MY154683A (es)
NZ (1) NZ596928A (es)
PE (1) PE20120322A1 (es)
PL (1) PL2451438T3 (es)
PT (1) PT2451438E (es)
RS (1) RS53209B (es)
SG (1) SG177569A1 (es)
SI (1) SI2451438T1 (es)
TN (1) TN2012000009A1 (es)
TW (1) TWI490216B (es)
UA (1) UA104195C2 (es)
UY (1) UY32760A (es)
WO (1) WO2011005646A2 (es)

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Also Published As

Publication number Publication date
EP2451438A2 (en) 2012-05-16
RS53209B (en) 2014-06-30
CA2767692C (en) 2017-03-07
AU2010270783B2 (en) 2013-06-27
CO6480980A2 (es) 2012-07-16
CL2012000054A1 (es) 2012-10-12
JP2012532192A (ja) 2012-12-13
EP2451438B8 (en) 2014-04-09
ME01718B (me) 2014-09-20
CA2767692A1 (en) 2011-01-13
IL216098A (en) 2016-02-29
ES2464367T3 (es) 2014-06-02
EA201200096A1 (ru) 2012-08-30
EA023433B1 (ru) 2016-06-30
US20110160149A1 (en) 2011-06-30
MA33491B1 (fr) 2012-08-01
NZ596928A (en) 2013-05-31
JP5607736B2 (ja) 2014-10-15
KR101685941B1 (ko) 2016-12-13
PL2451438T3 (pl) 2014-07-31
CN102470103A (zh) 2012-05-23
EP2451438B1 (en) 2014-02-26
PT2451438E (pt) 2014-03-26
UY32760A (es) 2011-02-28
PE20120322A1 (es) 2012-04-14
BR112012000287A2 (pt) 2016-02-23
AU2010270783A1 (en) 2011-12-15
WO2011005646A3 (en) 2011-12-22
BR112012000287B8 (pt) 2021-05-25
IL216098A0 (en) 2012-01-31
AP2011005979A0 (en) 2011-12-31
MY154683A (en) 2015-07-15
WO2011005646A2 (en) 2011-01-13
DK2451438T3 (da) 2014-03-10
SI2451438T1 (sl) 2014-04-30
HRP20140445T1 (hr) 2014-06-20
TW201114766A (en) 2011-05-01
TWI490216B (zh) 2015-07-01
KR20120059481A (ko) 2012-06-08
MX2011013824A (es) 2012-01-30
CN102470103B (zh) 2016-09-07
US9034831B2 (en) 2015-05-19
ECSP12011624A (es) 2012-02-29
UA104195C2 (ru) 2014-01-10
SG177569A1 (en) 2012-03-29
BR112012000287B1 (pt) 2020-12-08
GEP20146016B (en) 2014-01-27
TN2012000009A1 (en) 2013-09-19

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