EA201201235A1 - Комбинации фармацевтических агентов в качестве ингибиторов репликации hcv - Google Patents
Комбинации фармацевтических агентов в качестве ингибиторов репликации hcvInfo
- Publication number
- EA201201235A1 EA201201235A1 EA201201235A EA201201235A EA201201235A1 EA 201201235 A1 EA201201235 A1 EA 201201235A1 EA 201201235 A EA201201235 A EA 201201235A EA 201201235 A EA201201235 A EA 201201235A EA 201201235 A1 EA201201235 A1 EA 201201235A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical agent
- hcv replication
- agent combinations
- hcv
- replication inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/204—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Изобретение относится к фармацевтическим агентам, которые вводят субъекту в составе комбинации или последовательно, предназначенным для лечения вирусной инфекции, вызванной Flaviviridae, например вируса гепатита C (HCV), где лечение включает введение соединения, которое эффективно подавляет функционирование белка NS5A HCV, и дополнительного соединения или комбинации соединений с противовирусной активностью в отношении HCV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31057910P | 2010-03-04 | 2010-03-04 | |
PCT/US2010/044591 WO2011109037A1 (en) | 2010-03-04 | 2010-08-05 | Combination pharmaceutical agents as inhibitors of hcv replication |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201201235A1 true EA201201235A1 (ru) | 2013-04-30 |
Family
ID=44531519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201201235A EA201201235A1 (ru) | 2010-03-04 | 2010-08-05 | Комбинации фармацевтических агентов в качестве ингибиторов репликации hcv |
Country Status (11)
Country | Link |
---|---|
US (1) | US9060971B2 (ru) |
EP (1) | EP2542074A4 (ru) |
JP (1) | JP2013521279A (ru) |
KR (1) | KR20120124495A (ru) |
CN (1) | CN102858157A (ru) |
AU (1) | AU2010347272A1 (ru) |
BR (1) | BR112012022311A2 (ru) |
CA (1) | CA2791630A1 (ru) |
EA (1) | EA201201235A1 (ru) |
MX (1) | MX2012010252A (ru) |
WO (1) | WO2011109037A1 (ru) |
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-
2010
- 2010-08-05 US US12/851,350 patent/US9060971B2/en not_active Expired - Fee Related
- 2010-08-05 KR KR1020127025741A patent/KR20120124495A/ko not_active Application Discontinuation
- 2010-08-05 CN CN2010800662365A patent/CN102858157A/zh active Pending
- 2010-08-05 EP EP10847147.5A patent/EP2542074A4/en not_active Withdrawn
- 2010-08-05 CA CA2791630A patent/CA2791630A1/en not_active Abandoned
- 2010-08-05 JP JP2012556049A patent/JP2013521279A/ja active Pending
- 2010-08-05 WO PCT/US2010/044591 patent/WO2011109037A1/en active Application Filing
- 2010-08-05 AU AU2010347272A patent/AU2010347272A1/en not_active Abandoned
- 2010-08-05 EA EA201201235A patent/EA201201235A1/ru unknown
- 2010-08-05 MX MX2012010252A patent/MX2012010252A/es not_active Application Discontinuation
- 2010-08-05 BR BR112012022311A patent/BR112012022311A2/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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MX2012010252A (es) | 2013-02-01 |
KR20120124495A (ko) | 2012-11-13 |
US9060971B2 (en) | 2015-06-23 |
EP2542074A4 (en) | 2014-05-14 |
CN102858157A (zh) | 2013-01-02 |
JP2013521279A (ja) | 2013-06-10 |
BR112012022311A2 (pt) | 2016-08-23 |
EP2542074A1 (en) | 2013-01-09 |
WO2011109037A1 (en) | 2011-09-09 |
US20110217261A1 (en) | 2011-09-08 |
CA2791630A1 (en) | 2011-09-09 |
AU2010347272A1 (en) | 2012-09-20 |
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