EA201591702A1 - Комбинация двух противовирусных препаратов для лечения гепатита c - Google Patents

Комбинация двух противовирусных препаратов для лечения гепатита c

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Publication number
EA201591702A1
EA201591702A1 EA201591702A EA201591702A EA201591702A1 EA 201591702 A1 EA201591702 A1 EA 201591702A1 EA 201591702 A EA201591702 A EA 201591702A EA 201591702 A EA201591702 A EA 201591702A EA 201591702 A1 EA201591702 A1 EA 201591702A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
hepatitis
combination
viral preparations
weeks
Prior art date
Application number
EA201591702A
Other languages
English (en)
Other versions
EA033257B1 (ru
Inventor
Барри М. Бернстейн
Сандип ДУТТА
Вэй ЛЮ
Томас Дж. Подсадеки
Эндрю Л. Кэмпбелл
Раджив М. Менон
Чих-Вэй Лин
Тяньли Ван
Валид М. Авни
Original Assignee
Эббви Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50588882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201591702(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эббви Инк. filed Critical Эббви Инк.
Publication of EA201591702A1 publication Critical patent/EA201591702A1/ru
Publication of EA033257B1 publication Critical patent/EA033257B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Данное изобретение относится к безинтерфероновым и безрибавириновым терапевтическим методам для лечения HCV. Предпочтительно, чтобы лечение имело меньшую продолжительность, например не более 12 недель. В одном аспекте лечение включает в себя введение по меньшей мере двух противовирусных препаратов прямого действия без интерферона и рибавирина субъекту с HCV-инфекцией, где лечение продолжается в течение 12 недель, и указанные по меньшей мере два противовирусных препарата прямого действия включают (а) соединение 1 или его фармацевтически приемлемую соль и (b) соединение 2 или его фармацевтически приемлемую соль.
EA201591702A 2013-03-14 2014-03-14 Комбинация двух противовирусных препаратов для лечения гепатита c EA033257B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783376P 2013-03-14 2013-03-14
PCT/US2014/027423 WO2014152514A1 (en) 2013-03-14 2014-03-14 Combination of two antivirals for treating hepatitis c

Publications (2)

Publication Number Publication Date
EA201591702A1 true EA201591702A1 (ru) 2016-09-30
EA033257B1 EA033257B1 (ru) 2019-09-30

Family

ID=50588882

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201591702A EA033257B1 (ru) 2013-03-14 2014-03-14 Комбинация двух противовирусных препаратов для лечения гепатита c
EA201991174A EA201991174A1 (ru) 2013-03-14 2014-03-14 Комбинация двух противовирусных препаратов для лечения гепатита c

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201991174A EA201991174A1 (ru) 2013-03-14 2014-03-14 Комбинация двух противовирусных препаратов для лечения гепатита c

Country Status (26)

Country Link
US (1) US20140275099A1 (ru)
EP (3) EP2968301B1 (ru)
JP (4) JP6441303B2 (ru)
KR (2) KR102210935B1 (ru)
CN (2) CN105073113B (ru)
AU (2) AU2014239563B2 (ru)
BR (1) BR112015023017B1 (ru)
CA (1) CA2901810C (ru)
CY (2) CY1119025T1 (ru)
DK (2) DK2968301T3 (ru)
EA (2) EA033257B1 (ru)
ES (2) ES2824473T3 (ru)
HK (2) HK1223817A1 (ru)
HR (2) HRP20171036T1 (ru)
HU (2) HUE052113T2 (ru)
IL (1) IL240419B (ru)
LT (2) LT3213750T (ru)
MX (2) MX362616B (ru)
NZ (2) NZ719137A (ru)
PL (2) PL3213750T3 (ru)
PT (2) PT2968301T (ru)
RS (2) RS60881B1 (ru)
SG (2) SG11201507364SA (ru)
SI (2) SI3213750T1 (ru)
TW (2) TWI642436B (ru)
WO (1) WO2014152514A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6441303B2 (ja) 2013-03-14 2018-12-19 アッヴィ・インコーポレイテッド Ｃ型肝炎を治療するための２種の抗ウイルス剤の併用
WO2017007934A1 (en) * 2015-07-08 2017-01-12 Abbvie Inc. Methods for treating hcv
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
CN106456621A (zh) * 2013-03-14 2017-02-22 艾伯维公司 用于治疗hcv的方法
CA2916912A1 (en) * 2013-07-02 2015-01-08 Abbvie Inc. Methods for treating hcv
MX2016005393A (es) * 2013-10-25 2016-08-11 Abbvie Inc Metodos para tratar vhc.
US20150174194A1 (en) * 2013-12-19 2015-06-25 Abbvie Inc. Methods for treating liver transplant recipients
CN112704726A (zh) * 2014-04-02 2021-04-27 艾伯维公司 治疗hcv的方法
CR20180030A (es) * 2015-06-26 2018-05-24 Abbvie Inc Composiciones farmacéuticas sólidas para el tratamiento del vhc.
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
US20230385268A1 (en) * 2022-05-17 2023-11-30 Abbvie Inc. Methods for Treating HCV
CN108024964B (zh) * 2015-07-17 2022-05-03 艾伯维公司 用于治疗hcv的固体药物组合物
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
CA3037719A1 (en) * 2016-09-23 2018-03-29 Abbvie Inc. Dose adjustment
CA2994496A1 (en) * 2017-02-14 2018-08-14 Abbvie Inc. Methods for treating hcv
CA2981993A1 (en) * 2017-08-02 2019-02-02 Abbvie Inc. Methods for treating hcv
EP3773753A4 (en) * 2018-04-10 2021-12-22 ATEA Pharmaceuticals, Inc. TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS
WO2020106835A1 (en) 2018-11-20 2020-05-28 Abbvie Inc. Methods for treating acute hcv
KR102077833B1 (ko) 2018-12-10 2020-02-14 류형준 기능성 식품조성물
CN111688355B (zh) 2019-03-15 2022-04-12 精工爱普生株式会社 液体吸收体、液体吸收器以及液体喷出装置
BR112021020222A2 (pt) * 2019-04-08 2021-12-21 Abbvie Inc Composições farmacêuticas sólidas para tratar hcv

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394279B2 (en) * 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
US8937150B2 (en) * 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
NZ608720A (en) 2010-09-21 2015-03-27 Enanta Pharm Inc Macrocyclic proline derived hcv serine protease inhibitors
US8330139B2 (en) 2011-03-25 2012-12-11 Micron Technology, Inc. Multi-level memory cell
AR088463A1 (es) 2011-10-21 2014-06-11 Abbvie Inc Metodos para el tratamiento de hcv
ES2527544T1 (es) 2011-10-21 2015-01-26 Abbvie Inc. Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC
SG10201702248UA (en) * 2012-09-18 2017-04-27 Abbvie Inc Methods for treating hepatitis c
JP6441303B2 (ja) 2013-03-14 2018-12-19 アッヴィ・インコーポレイテッド Ｃ型肝炎を治療するための２種の抗ウイルス剤の併用

Also Published As

Publication number Publication date
CA2901810A1 (en) 2014-09-25
PL2968301T3 (pl) 2017-09-29
WO2014152514A1 (en) 2014-09-25
IL240419B (en) 2019-03-31
HUE033010T2 (en) 2017-11-28
SG10201708306WA (en) 2017-11-29
PT3213750T (pt) 2020-10-19
EP3213750B1 (en) 2020-08-12
US20140275099A1 (en) 2014-09-18
IL240419A0 (en) 2015-09-24
RS56202B1 (sr) 2017-11-30
JP2016513695A (ja) 2016-05-16
EA033257B1 (ru) 2019-09-30
CN108159393A (zh) 2018-06-15
AU2016202823A1 (en) 2016-05-19
AU2014239563A1 (en) 2015-08-27
CN105073113B (zh) 2018-01-02
SI2968301T1 (sl) 2017-07-31
MX362616B (es) 2019-01-28
CN105073113A (zh) 2015-11-18
JP2020037589A (ja) 2020-03-12
EP2968301A1 (en) 2016-01-20
HK1223817A1 (zh) 2017-08-11
MX2020005054A (es) 2020-08-20
DK2968301T3 (en) 2017-07-24
HRP20201575T1 (hr) 2020-12-11
BR112015023017A2 (pt) 2017-07-18
EP3766495A1 (en) 2021-01-20
TW201511759A (zh) 2015-04-01
MX2015012538A (es) 2016-02-10
KR102210935B1 (ko) 2021-02-02
JP6621902B2 (ja) 2019-12-18
NZ631155A (en) 2016-05-27
JP2021130720A (ja) 2021-09-09
CY1123387T1 (el) 2021-12-31
AU2016202823B2 (en) 2017-11-23
JP6441303B2 (ja) 2018-12-19
RS60881B1 (sr) 2020-11-30
EP2968301B1 (en) 2017-04-19
AU2014239563B2 (en) 2016-05-05
TWI686196B (zh) 2020-03-01
NZ719137A (en) 2017-11-24
TW201834656A (zh) 2018-10-01
ES2824473T3 (es) 2021-05-12
LT2968301T (lt) 2017-05-25
EA201991174A1 (ru) 2020-01-31
HK1244668A1 (zh) 2018-08-17
LT3213750T (lt) 2020-10-26
PL3213750T3 (pl) 2020-12-14
CA2901810C (en) 2019-01-08
DK3213750T3 (da) 2020-10-19
ES2624980T3 (es) 2017-07-18
PT2968301T (pt) 2017-07-17
CY1119025T1 (el) 2018-01-10
BR112015023017B1 (pt) 2022-08-30
JP2019048868A (ja) 2019-03-28
KR20150129032A (ko) 2015-11-18
SI3213750T1 (sl) 2020-11-30
HRP20171036T1 (hr) 2017-10-06
TWI642436B (zh) 2018-12-01
HUE052113T2 (hu) 2021-04-28
KR20210013344A (ko) 2021-02-03
EP3213750A1 (en) 2017-09-06
SG11201507364SA (en) 2015-10-29

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