JP2019048868A - C型肝炎を治療するための2種の抗ウイルス剤の併用 - Google Patents
C型肝炎を治療するための2種の抗ウイルス剤の併用 Download PDFInfo
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Abstract
Description
本発明の一態様は、HCV感染を治療するためのそのような治療を必要とする対象における方法を特徴とする。本法は、直接的に作用する少なくとも2種の抗ウイルス剤(DAA)を12週間以下の継続期間に、または本明細書に記載の他の継続期間に、対象に投与することを含む。当該少なくとも2種のDAAは、化合物1(または医薬として許容されるその塩)と化合物2(または医薬として許容されるその塩)とを含む。好ましくは、治療の継続期間は12週間である。治療の継続期間はまた、例えば8週間以下であり得る。好ましくは、当該2種以上のDAAは、ウイルス学的著効(SVR)をもたらすか、他の所望の尺度の有効性を対象内で達成するように、十分な量で投与される。治療レジメン中、対象はリバビリンを投与されない。治療レジメン中、対象はインターフェロンも投与されない。いわば本法は、対象へのインターフェロンまたはリバビリンの投与を排除し、その結果、インターフェロンおよびリバビリンに伴う副作用を回避するものである。
化合物1および化合物2の投与を含む治療レジメンは、全体が参照により本明細書に組み込まれている2012年10月19日に出願の「HCVを治療するための方法」と題された米国特許出願公開第2013/0102526号に記載された臨床モデルを使用して評価した。これらの治療レジメンは、化合物1および化合物2の投与を含んでいたが、インターフェロンとリバビリンのどちらの投与も含まなかった。
図7は、HCV GT1bのCon−1株を複製させた細胞で試験した場合に、化合物1と化合物2との併用がHCV阻害に著しい相乗効果を発揮することを示す。この結果はプリチャード(Prichard)およびシップマン(Shipman)のモデル[Prichardら、ANTIVIRAL RESEARCH 14:181−205(1990)]を使用して生じたものである。
Claims (24)
- HCV患者に少なくとも2種の直接的に作用する抗ウイルス剤(DAA)を投与することを含む、HCVの治療方法であって、治療中にインターフェロンもリバビリンも患者に投与せず、治療が8、9、10、11または12週間継続し、少なくとも2種のDAAが
化合物1または医薬として許容されるその塩および
化合物2または医薬として許容されるその塩
を含む、方法。 - 治療が12週間継続する、請求項1に記載の方法。
- 患者がHCV遺伝子型1に感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型1aに感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型2に感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型3に感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型4に感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型5に感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型6に感染している、請求項1に記載の方法。
- 患者がHCV遺伝子型1に感染している、請求項2に記載の方法。
- 患者がHCV遺伝子型1aに感染している、請求項2に記載の方法。
- 患者がHCV遺伝子型2に感染している、請求項2に記載の方法。
- 患者がHCV遺伝子型3に感染している、請求項2に記載の方法。
- 患者がHCV遺伝子型4に感染している、請求項2に記載の方法。
- 患者がHCV遺伝子型5に感染している、請求項2に記載の方法。
- 患者がHCV遺伝子型6に感染している、請求項2に記載の方法。
- 患者が肝硬変でない、請求項1に記載の方法。
- 患者が代償性肝硬変である、請求項1に記載の方法。
- 患者が肝硬変でない、請求項2に記載の方法。
- 患者が代償性肝硬変である、請求項2に記載の方法。
- 患者が治療未経験の患者である、請求項1に記載の方法。
- 患者がインターフェロン非応答者である、請求項1に記載の方法。
- 患者が治療未経験の患者である、請求項2に記載の方法。
- 患者がインターフェロン非応答者である、請求項2に記載の方法。
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RS56202B1 (sr) | 2013-03-14 | 2017-11-30 | Abbvie Inc | Kombinacija dva antivirotika za lečenje hepatitisa c |
CA2916912A1 (en) * | 2013-07-02 | 2015-01-08 | Abbvie Inc. | Methods for treating hcv |
CA2925328A1 (en) * | 2013-10-25 | 2015-04-30 | Abbvie, Inc. | Methods for treating hcv |
WO2015095572A1 (en) * | 2013-12-19 | 2015-06-25 | Abbvie Inc. | Methods for treating liver transplant recipients |
CN110302361A (zh) * | 2014-04-02 | 2019-10-08 | 艾伯维公司 | 治疗hcv的方法 |
JP7162425B2 (ja) * | 2015-06-26 | 2022-10-28 | アッヴィ・インコーポレイテッド | Hcvを処置するための固体医薬組成物 |
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AU2016291154B2 (en) * | 2015-07-08 | 2021-10-21 | Abbvie Inc. | Methods for treating HCV |
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EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
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