EA201691008A1 - 7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-a]пиридо[3,4-e]пиримидин-5(1h)-он, его соли и способы применения - Google Patents

7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-a]пиридо[3,4-e]пиримидин-5(1h)-он, его соли и способы применения

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Publication number
EA201691008A1
EA201691008A1 EA201691008A EA201691008A EA201691008A1 EA 201691008 A1 EA201691008 A1 EA 201691008A1 EA 201691008 A EA201691008 A EA 201691008A EA 201691008 A EA201691008 A EA 201691008A EA 201691008 A1 EA201691008 A1 EA 201691008A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methylbenzil
pirido
hexahydroimidazo
pyrimidin
benzyl
Prior art date
Application number
EA201691008A
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English (en)
Other versions
EA033744B1 (ru
Inventor
Мартин Стогниев
Джошуа Е. Аллен
Ричард С. Потторф
Бхаскара Рао Наллаганчу
Гэри Л. Олсон
Original Assignee
Онкосьютикс, Инк.
Провид Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US14/208,657 external-priority patent/US9265765B2/en
Priority claimed from US14/341,392 external-priority patent/US9376437B2/en
Priority claimed from PCT/US2014/048241 external-priority patent/WO2015073072A1/en
Application filed by Онкосьютикс, Инк., Провид Фармасьютикалз Инк. filed Critical Онкосьютикс, Инк.
Publication of EA201691008A1 publication Critical patent/EA201691008A1/ru
Publication of EA033744B1 publication Critical patent/EA033744B1/ru

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Abstract

Настоящее изобретение относится, по меньшей мере частично, к способу лечения. В одном варианте реализации способ лечения включает введение субъекту, нуждающемуся в таком лечении, первого терапевтического агента, включающего соединение (1)или его фармацевтически приемлемую соль, в комбинации со вторым терапевтическим агентом, при этом указанные первый терапевтический агент и второй терапевтический агент вводят одновременно или последовательно.
EA201691008A 2013-11-15 2014-09-12 7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-a]пиридо[3,4-e]пиримидин-5(1h)-он, его соли и способы применения EA033744B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361904718P 2013-11-15 2013-11-15
US14/208,657 US9265765B2 (en) 2013-03-13 2014-03-13 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-A]pyrido[4,3-D]pyrimidin-5(3H)-one, salts thereof and methods of using the same in combination therapy
US14/341,392 US9376437B2 (en) 2013-03-13 2014-07-25 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
PCT/US2014/048241 WO2015073072A1 (en) 2013-11-15 2014-07-25 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
PCT/US2014/055373 WO2015073109A1 (en) 2013-11-15 2014-09-12 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, salts thereof and methods of use

Publications (2)

Publication Number Publication Date
EA201691008A1 true EA201691008A1 (ru) 2016-10-31
EA033744B1 EA033744B1 (ru) 2019-11-21

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EP (3) EP3546461B1 (ru)
JP (4) JP6670751B2 (ru)
KR (4) KR20220140042A (ru)
CN (2) CN110669047A (ru)
AU (3) AU2014349150B2 (ru)
BR (1) BR112016011072B1 (ru)
CA (2) CA3204925A1 (ru)
CY (2) CY1121628T1 (ru)
DK (2) DK3546461T3 (ru)
EA (1) EA033744B1 (ru)
ES (2) ES2895600T3 (ru)
HR (2) HRP20211653T8 (ru)
HU (2) HUE056389T2 (ru)
IL (5) IL296386B1 (ru)
LT (2) LT3068401T (ru)
ME (1) ME03387B (ru)
MX (3) MX2016006318A (ru)
PL (2) PL3068401T3 (ru)
PT (2) PT3546461T (ru)
RS (2) RS58745B1 (ru)
SG (1) SG10201809189UA (ru)
SI (2) SI3546461T1 (ru)
TR (1) TR201906711T4 (ru)
WO (1) WO2015073109A1 (ru)

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