EA201491525A1 - Спиро[2.4]гептаны для лечения инфекций, вызванных flaviviridae - Google Patents

Спиро[2.4]гептаны для лечения инфекций, вызванных flaviviridae

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Publication number
EA201491525A1
EA201491525A1 EA201491525A EA201491525A EA201491525A1 EA 201491525 A1 EA201491525 A1 EA 201491525A1 EA 201491525 A EA201491525 A EA 201491525A EA 201491525 A EA201491525 A EA 201491525A EA 201491525 A1 EA201491525 A1 EA 201491525A1
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EA
Eurasian Patent Office
Prior art keywords
spiro
treatment
infections caused
flaviviridae
heptans
Prior art date
Application number
EA201491525A
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English (en)
Inventor
Чанг К. ЧУ
Original Assignee
Юниверсити Оф Джорджиа Рисерч Фаундэйшн, Инк.
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Application filed by Юниверсити Оф Джорджиа Рисерч Фаундэйшн, Инк. filed Critical Юниверсити Оф Джорджиа Рисерч Фаундэйшн, Инк.
Publication of EA201491525A1 publication Critical patent/EA201491525A1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
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Abstract

Представлены соединения, способы и композиции для лечения инфекций, вызванных вирусами Flaviviridae, в том числе HCV, или результатов воздействия таковых у людей и других животных-хозяев, которые предусматривают введение эффективного количества спиро[2.4]гептана, описанного в настоящем документе, или его фармацевтически приемлемой соли или пролекарства, необязательно в фармацевтически приемлемом носителе. Спиро[2.4]гептановые соединения либо обладают противовирусной активностью, либо метаболизируются до соединения, которое проявляет такую активность.
EA201491525A 2012-02-14 2013-02-14 Спиро[2.4]гептаны для лечения инфекций, вызванных flaviviridae EA201491525A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261598524P 2012-02-14 2012-02-14
US201261615975P 2012-03-27 2012-03-27
US201261615989P 2012-03-27 2012-03-27
PCT/US2013/026062 WO2013123138A2 (en) 2012-02-14 2013-02-14 Spiro [2.4]heptanes for treatment of flaviviridae infections

Publications (1)

Publication Number Publication Date
EA201491525A1 true EA201491525A1 (ru) 2014-12-30

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EA201491525A EA201491525A1 (ru) 2012-02-14 2013-02-14 Спиро[2.4]гептаны для лечения инфекций, вызванных flaviviridae

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Country Link
US (4) US8673926B2 (ru)
EP (1) EP2814816A2 (ru)
JP (1) JP2015517975A (ru)
KR (1) KR20140129019A (ru)
AU (1) AU2013221571A1 (ru)
BR (1) BR112014019897A8 (ru)
CA (1) CA2864098A1 (ru)
EA (1) EA201491525A1 (ru)
IL (1) IL234067A0 (ru)
IN (1) IN2014DN06495A (ru)
MD (1) MD20140094A2 (ru)
MX (1) MX2014009850A (ru)
RU (1) RU2014136887A (ru)
SG (1) SG11201404706XA (ru)
WO (1) WO2013123138A2 (ru)

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