EA201391685A1 - Ингибиторы вируса гепатита с - Google Patents

Ингибиторы вируса гепатита с

Info

Publication number
EA201391685A1
EA201391685A1 EA201391685A EA201391685A EA201391685A1 EA 201391685 A1 EA201391685 A1 EA 201391685A1 EA 201391685 A EA201391685 A EA 201391685A EA 201391685 A EA201391685 A EA 201391685A EA 201391685 A1 EA201391685 A1 EA 201391685A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatitis
compounds
virus inhibitors
hcv
methods
Prior art date
Application number
EA201391685A
Other languages
English (en)
Other versions
EA024201B1 (ru
Inventor
Ци Чэнь
Омар Д. Лопез
Джон А. Бендер
Гань Ван
Ван Н. Нгуен
Джон Ф. Кадов
Николас А. Минвелл
Маконен Белема
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46147738&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201391685(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201391685A1 publication Critical patent/EA201391685A1/ru
Publication of EA024201B1 publication Critical patent/EA024201B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям, композициям и способам лечения инфекционного заболевания, вызванного вирусом гепатита С (HCV). В описании также представлены фармацевтические композиции, содержащие такие соединения, и способы использования этих соединений при лечении HCV-инфицированных пациентов.
EA201391685A 2011-05-12 2012-05-09 Ингибиторы вируса гепатита с EA024201B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161485224P 2011-05-12 2011-05-12
US13/465,298 US9546160B2 (en) 2011-05-12 2012-05-07 Hepatitis C virus inhibitors
PCT/US2012/037012 WO2012154777A1 (en) 2011-05-12 2012-05-09 Hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
EA201391685A1 true EA201391685A1 (ru) 2014-03-31
EA024201B1 EA024201B1 (ru) 2016-08-31

Family

ID=46147738

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391685A EA024201B1 (ru) 2011-05-12 2012-05-09 Ингибиторы вируса гепатита с

Country Status (21)

Country Link
US (1) US9546160B2 (ru)
EP (1) EP2707365B1 (ru)
JP (1) JP5977819B2 (ru)
KR (1) KR20140037114A (ru)
CN (1) CN103827108B (ru)
AR (1) AR086389A1 (ru)
AU (1) AU2012253578A1 (ru)
BR (1) BR112013028679A2 (ru)
CA (1) CA2835688A1 (ru)
CL (1) CL2013003229A1 (ru)
CO (1) CO6821952A2 (ru)
EA (1) EA024201B1 (ru)
IL (1) IL229331A0 (ru)
MA (1) MA35104B1 (ru)
MX (1) MX2013012870A (ru)
PE (1) PE20150105A1 (ru)
SG (1) SG194846A1 (ru)
TW (1) TW201249834A (ru)
UY (1) UY34066A (ru)
WO (1) WO2012154777A1 (ru)
ZA (1) ZA201309356B (ru)

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EP2707365B1 (en) 2018-10-17
EA024201B1 (ru) 2016-08-31
AU2012253578A1 (en) 2014-01-16
EP2707365A1 (en) 2014-03-19
US9546160B2 (en) 2017-01-17
WO2012154777A1 (en) 2012-11-15
KR20140037114A (ko) 2014-03-26
ZA201309356B (en) 2015-05-27
CA2835688A1 (en) 2012-11-15
MX2013012870A (es) 2014-02-20
BR112013028679A2 (pt) 2017-01-24
CL2013003229A1 (es) 2014-09-05
IL229331A0 (en) 2014-01-30
US20130121957A1 (en) 2013-05-16
AR086389A1 (es) 2013-12-11
TW201249834A (en) 2012-12-16
JP2014513690A (ja) 2014-06-05
SG194846A1 (en) 2013-12-30
CO6821952A2 (es) 2013-12-31
CN103827108A (zh) 2014-05-28
CN103827108B (zh) 2018-05-15
JP5977819B2 (ja) 2016-08-24
UY34066A (es) 2012-11-30

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