EA201691777A1 - Содержащие цианогруппу соединения азабензофурана для лечения гепатита с - Google Patents

Содержащие цианогруппу соединения азабензофурана для лечения гепатита с

Info

Publication number
EA201691777A1
EA201691777A1 EA201691777A EA201691777A EA201691777A1 EA 201691777 A1 EA201691777 A1 EA 201691777A1 EA 201691777 A EA201691777 A EA 201691777A EA 201691777 A EA201691777 A EA 201691777A EA 201691777 A1 EA201691777 A1 EA 201691777A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
hepatitis
treatment
cyanogrupe
azabenzofurane
Prior art date
Application number
EA201691777A
Other languages
English (en)
Inventor
Тао Ван
Кайл Джей. Истман
Жонксин Жан
Кайл Е. Парселла
Живей Йин
Джон Ф. Кадоу
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201691777A1 publication Critical patent/EA201691777A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Представлены соединения формулы I, включая их соли, а также композиции и способы применения соединений. Соединения обладают активностью по отношению к вирусу гепатита С (HCV) и могут быть применимы при лечении инфицированных HCV.
EA201691777A 2014-03-21 2015-03-20 Содержащие цианогруппу соединения азабензофурана для лечения гепатита с EA201691777A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461968763P 2014-03-21 2014-03-21
PCT/US2015/021638 WO2015143255A1 (en) 2014-03-21 2015-03-20 Cyano containing azabenzofuran compounds for the treatment of hepatitis c

Publications (1)

Publication Number Publication Date
EA201691777A1 true EA201691777A1 (ru) 2016-12-30

Family

ID=52808191

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691777A EA201691777A1 (ru) 2014-03-21 2015-03-20 Содержащие цианогруппу соединения азабензофурана для лечения гепатита с

Country Status (18)

Country Link
US (1) US9249152B2 (ru)
EP (1) EP3119785B1 (ru)
JP (1) JP2017509700A (ru)
KR (1) KR20160126085A (ru)
CN (1) CN106459070A (ru)
AR (1) AR099820A1 (ru)
AU (1) AU2015231139A1 (ru)
CA (1) CA2943526A1 (ru)
CL (1) CL2016002361A1 (ru)
EA (1) EA201691777A1 (ru)
ES (1) ES2688554T3 (ru)
IL (1) IL247830A0 (ru)
MX (1) MX2016012104A (ru)
PE (1) PE20161224A1 (ru)
SG (1) SG11201607750PA (ru)
TW (1) TW201620914A (ru)
WO (1) WO2015143255A1 (ru)
ZA (1) ZA201606478B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015143256A1 (en) * 2014-03-21 2015-09-24 Bristol-Myers Squibb Company Cyanoamino (aza)benzofuran compounds for the treatment of hepatitis c
CA3007462C (en) * 2015-12-07 2023-10-24 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041201A2 (en) 2002-11-01 2004-05-21 Viropharma Incorporated Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
KR20100117073A (ko) 2008-02-14 2010-11-02 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
US8198449B2 (en) * 2008-09-11 2012-06-12 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8048887B2 (en) * 2008-09-11 2011-11-01 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7994171B2 (en) * 2008-09-11 2011-08-09 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
EP2545050B1 (en) 2010-03-10 2014-08-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis c
WO2012058125A1 (en) 2010-10-26 2012-05-03 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus

Also Published As

Publication number Publication date
IL247830A0 (en) 2016-11-30
CA2943526A1 (en) 2015-09-24
WO2015143255A1 (en) 2015-09-24
AU2015231139A1 (en) 2016-11-03
PE20161224A1 (es) 2016-11-12
MX2016012104A (es) 2016-12-09
CL2016002361A1 (es) 2017-04-21
SG11201607750PA (en) 2016-10-28
EP3119785B1 (en) 2018-08-15
TW201620914A (zh) 2016-06-16
US20150266886A1 (en) 2015-09-24
ES2688554T3 (es) 2018-11-05
AR099820A1 (es) 2016-08-17
US9249152B2 (en) 2016-02-02
EP3119785A1 (en) 2017-01-25
CN106459070A (zh) 2017-02-22
ZA201606478B (en) 2018-05-30
JP2017509700A (ja) 2017-04-06
KR20160126085A (ko) 2016-11-01

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