IT201700026858A1 - Uso di inibitori delle serin proteasi, in particolare di serpinb3 - Google Patents

Uso di inibitori delle serin proteasi, in particolare di serpinb3

Info

Publication number
IT201700026858A1
IT201700026858A1 IT102017000026858A IT201700026858A IT201700026858A1 IT 201700026858 A1 IT201700026858 A1 IT 201700026858A1 IT 102017000026858 A IT102017000026858 A IT 102017000026858A IT 201700026858 A IT201700026858 A IT 201700026858A IT 201700026858 A1 IT201700026858 A1 IT 201700026858A1
Authority
IT
Italy
Prior art keywords
proteasis
serpinb3
serin
inhibitors
serin proteasis
Prior art date
Application number
IT102017000026858A
Other languages
English (en)
Inventor
Patrizia Pontisso
Alessandra Biasiolo
Andrea Cappon
Andrea Martini
Santina Quarta
Mariagrazia Ruvoletto
Cristian Turato
Gianmarco Villano
Original Assignee
Univ Degli Studi Padova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Padova filed Critical Univ Degli Studi Padova
Priority to IT102017000026858A priority Critical patent/IT201700026858A1/it
Priority to US16/491,858 priority patent/US11628163B2/en
Priority to ES18715258T priority patent/ES2948284T3/es
Priority to EP18715258.2A priority patent/EP3592351B1/en
Priority to PCT/IB2018/051554 priority patent/WO2018163119A1/en
Publication of IT201700026858A1 publication Critical patent/IT201700026858A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
IT102017000026858A 2017-03-10 2017-03-10 Uso di inibitori delle serin proteasi, in particolare di serpinb3 IT201700026858A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT102017000026858A IT201700026858A1 (it) 2017-03-10 2017-03-10 Uso di inibitori delle serin proteasi, in particolare di serpinb3
US16/491,858 US11628163B2 (en) 2017-03-10 2018-03-09 1-piperidinepropionic acid for treating a fibrosing disease
ES18715258T ES2948284T3 (es) 2017-03-10 2018-03-09 Acido 1-piperidinopropiónico para el tratamiento de una enfermedad fibrosante
EP18715258.2A EP3592351B1 (en) 2017-03-10 2018-03-09 1-piperidinepropionic acid for treating a fibrosing disease
PCT/IB2018/051554 WO2018163119A1 (en) 2017-03-10 2018-03-09 1-piperidinepropionic acid for treating a fibrosing disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000026858A IT201700026858A1 (it) 2017-03-10 2017-03-10 Uso di inibitori delle serin proteasi, in particolare di serpinb3

Publications (1)

Publication Number Publication Date
IT201700026858A1 true IT201700026858A1 (it) 2018-09-10

Family

ID=59521424

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000026858A IT201700026858A1 (it) 2017-03-10 2017-03-10 Uso di inibitori delle serin proteasi, in particolare di serpinb3

Country Status (5)

Country Link
US (1) US11628163B2 (it)
EP (1) EP3592351B1 (it)
ES (1) ES2948284T3 (it)
IT (1) IT201700026858A1 (it)
WO (1) WO2018163119A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021013921A1 (en) * 2019-07-25 2021-01-28 Universita' Degli Studi Di Padova The serpinb3 inhibitor piperidinpropionic acid for tumor treatment
WO2024013666A1 (en) * 2022-07-12 2024-01-18 Università Degli Studi Di Padova Protease activated receptor 2 (par2) inhibitor and its uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401763D0 (sv) * 2004-07-05 2004-07-05 Astrazeneca Ab Compounds
PL2144604T3 (pl) * 2007-02-28 2012-02-29 Conatus Pharmaceuticals Inc Sposoby leczenia przewlekłego zapalenia wątroby typu C z zastosowaniem RO 113-0830
JP5300302B2 (ja) 2008-03-31 2013-09-25 株式会社 資生堂 １−ピペリジンプロピオン酸及び／またはその塩を活性成分とするｓｃｃａ−１産生抑制剤
JP2012240911A (ja) * 2011-05-13 2012-12-10 Shiseido Co Ltd １−ピペリジンプロピオン酸からなる、抗シワ剤、マトリックスメタロプロテアーゼ（ｍｍｐ）抑制剤、及び／又はラミニン５産生促進剤
WO2013148232A1 (en) * 2012-03-27 2013-10-03 Genentech, Inc. Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRANCESCA LUNARDI ET AL: "Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice", LABORATORY INVESTIGATION, vol. 91, no. 6, 14 March 2011 (2011-03-14), The United States and Canadian Academy of Pathology, Inc., pages 945 - 954, XP055432106, ISSN: 0023-6837, DOI: 10.1038/labinvest.2011.1 *
HIBINO ET AL: "Role of caspase -14 in DNA degradation and its application to cosmetic products", NIPPON KOSHOHIN GAKKAISHI, NIHON KOSHOHIN GAKKAI, JP, vol. 34, no. 2, 1 January 2010 (2010-01-01), pages 108 - 112, XP009502153, ISSN: 1880-2532 *

Also Published As

Publication number Publication date
ES2948284T3 (es) 2023-09-07
EP3592351A1 (en) 2020-01-15
US11628163B2 (en) 2023-04-18
US20210137905A1 (en) 2021-05-13
EP3592351B1 (en) 2023-05-10
WO2018163119A1 (en) 2018-09-13

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