DK3362450T3 - N1- og N7-substituerede sibirilin-derivater og anvendelse deraf som inhibitorer af cellulær nekroptose - Google Patents
N1- og N7-substituerede sibirilin-derivater og anvendelse deraf som inhibitorer af cellulær nekroptose Download PDFInfo
- Publication number
- DK3362450T3 DK3362450T3 DK16784435.6T DK16784435T DK3362450T3 DK 3362450 T3 DK3362450 T3 DK 3362450T3 DK 16784435 T DK16784435 T DK 16784435T DK 3362450 T3 DK3362450 T3 DK 3362450T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- substituted
- sibiriline
- derivatives
- cellular necroptosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306623 | 2015-10-13 | ||
| PCT/EP2016/074637 WO2017064216A1 (en) | 2015-10-13 | 2016-10-13 | N1- and n7-substituted sibiriline derivatives and their use as inhibitor of cellular necroptosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3362450T3 true DK3362450T3 (da) | 2020-09-14 |
Family
ID=54337711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16784435.6T DK3362450T3 (da) | 2015-10-13 | 2016-10-13 | N1- og N7-substituerede sibirilin-derivater og anvendelse deraf som inhibitorer af cellulær nekroptose |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10457678B2 (da) |
| EP (1) | EP3362450B1 (da) |
| DK (1) | DK3362450T3 (da) |
| ES (1) | ES2821971T3 (da) |
| PL (1) | PL3362450T3 (da) |
| WO (1) | WO2017064216A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3362449T3 (da) * | 2015-10-13 | 2021-07-19 | Inst Nat Sante Rech Med | Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| EP4281070A1 (en) * | 2021-01-25 | 2023-11-29 | Seabelife | Use of indole, 6- and 7-azaindole derivatives as inhibitors of ferroptosis regulated cell death |
| WO2024115793A1 (en) | 2022-12-02 | 2024-06-06 | Seabelife | Synergistic combinations of regulated necrosis inhibitors with n-acetylcysteine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998047899A1 (en) | 1997-04-24 | 1998-10-29 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| WO2005077344A2 (en) | 2003-08-29 | 2005-08-25 | The Brigham And Women's Hospital, Inc. | Hydantoin derivatives as inhibitors of cellular necrosis |
| US9180127B2 (en) * | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
| US9643977B2 (en) | 2011-03-11 | 2017-05-09 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
-
2016
- 2016-10-13 DK DK16784435.6T patent/DK3362450T3/da active
- 2016-10-13 EP EP16784435.6A patent/EP3362450B1/en active Active
- 2016-10-13 ES ES16784435T patent/ES2821971T3/es active Active
- 2016-10-13 WO PCT/EP2016/074637 patent/WO2017064216A1/en active Application Filing
- 2016-10-13 US US15/768,395 patent/US10457678B2/en active Active
- 2016-10-13 PL PL16784435T patent/PL3362450T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3362450B1 (en) | 2020-07-01 |
| PL3362450T3 (pl) | 2021-08-23 |
| WO2017064216A1 (en) | 2017-04-20 |
| US10457678B2 (en) | 2019-10-29 |
| ES2821971T3 (es) | 2021-04-28 |
| EP3362450A1 (en) | 2018-08-22 |
| US20180312502A1 (en) | 2018-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3277681T3 (da) | Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer | |
| DK3371171T3 (da) | Inhibitorer af RET | |
| DK3149001T3 (da) | Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere | |
| DK3661921T3 (da) | Selektive hæmmere af nlrp3-inflammasom | |
| DK3259253T3 (da) | Sulfonylureaer og relaterede forbindelser og brug af samme | |
| DK3557998T3 (da) | Sammensætninger, kompositioner og anvendelsesmetoder | |
| DK3185868T3 (da) | Hidtil ukendte ULK1-inhibitorer og fremgangsmåder til anvendelse af samme | |
| DK3317284T3 (da) | Benzoxazepin-oxazolidinonforbindelser og fremgangsmåder til anvendelse | |
| DK3212778T3 (da) | Fremgangsmåder og sammensætninger til stabilisering af trans-splejsning af intein-modificerede proteaser | |
| DK3207043T6 (da) | Dihydropyrrolopyridin-inhibitorer af ror-gamma | |
| DK3221306T3 (da) | Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf | |
| DK3102576T3 (da) | Dihydropyrrolopyridininhibitorer af ror-gamma | |
| DK3160956T3 (da) | Inhibitorer af lysin-specifik demethylase-1 | |
| DK3484469T3 (da) | Sammensætninger og fremgangsmåder til potentiering af antimikrober | |
| DK3288553T3 (da) | Kombinationer af cannabinoider og n-acylethanolaminer | |
| DK3164380T3 (da) | Hæmmere af lysinspecifik demethylase-1 | |
| DK3144001T3 (da) | Sammensætninger af selenoorganiske forbindelser og fremgangsmåder til anvendelse deraf | |
| DK3215493T3 (da) | Syntese af copanlisib og dihydrochloridsalt deraf | |
| DK3313833T3 (da) | Forbindelser og anvendelse deraf som inhibitorer af n-myristoyl-transferase | |
| DK3348556T3 (da) | Heteroarylamider som hæmmere af proteinaggregering | |
| DK3341379T3 (da) | EZH2-hæmmere | |
| DK3766885T3 (da) | Tricykliske forbindelser og deres anvendelse som phoshodiesteraseinhibitorer | |
| DK3214079T3 (da) | Seks-leddede benzodiazepinderivater som dpp-4-inhibitorer og hvordan de bruges | |
| DK3319609T3 (da) | Sammensætninger og fremgangsmåder til anvendelse af antibakterielle lægemiddelkombinationer | |
| DK3347006T3 (da) | Deutererede analoger af etifoxin, derivater deraf og anvendelser deraf |