DK3221306T3 - Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf - Google Patents

Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf Download PDF

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Publication number
DK3221306T3
DK3221306T3 DK15801650.1T DK15801650T DK3221306T3 DK 3221306 T3 DK3221306 T3 DK 3221306T3 DK 15801650 T DK15801650 T DK 15801650T DK 3221306 T3 DK3221306 T3 DK 3221306T3
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Prior art keywords
iraqi
inhibitors
heteroaryl compounds
heteroaryl
compounds
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DK15801650.1T
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English (en)
Inventor
Catherine Jorand-Lebrun
Reinaldo Jones
Ngan Nguyen
Theresa L Johnson
Lizbeth Celeste Deselm
Kausik Panda
Annie Cho Won
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Merck Patent Gmbh
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DK15801650.1T 2014-11-20 2015-11-19 Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf DK3221306T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462082231P 2014-11-20 2014-11-20
PCT/US2015/061463 WO2016081679A1 (en) 2014-11-20 2015-11-19 Heteroaryl compounds as irak inhibitors and uses thereof

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US (2) US9790221B2 (da)
EP (1) EP3221306B1 (da)
JP (1) JP6787892B2 (da)
KR (2) KR20230158647A (da)
CN (1) CN107108561B (da)
AR (1) AR103138A1 (da)
AU (1) AU2015349899B9 (da)
CA (1) CA2964982C (da)
DK (1) DK3221306T3 (da)
ES (1) ES2772133T3 (da)
HR (1) HRP20200179T1 (da)
HU (1) HUE047586T2 (da)
IL (1) IL252346B (da)
LT (1) LT3221306T (da)
MX (1) MX2017006266A (da)
NZ (1) NZ730728A (da)
PL (1) PL3221306T3 (da)
PT (1) PT3221306T (da)
RS (1) RS59974B1 (da)
RU (1) RU2743718C2 (da)
SG (1) SG11201702741SA (da)
SI (1) SI3221306T1 (da)
WO (1) WO2016081679A1 (da)
ZA (1) ZA201702402B (da)

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WO2017144633A1 (en) * 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CA3041587A1 (en) 2016-10-26 2018-05-17 Rigel Pharmaceuticals, Inc. Oxazole derivatives for use as irak inhibitors and method for their preparation
WO2018081294A1 (en) 2016-10-26 2018-05-03 Rigel Pharmaceuticals, Inc. Pyrazole amide compounds as irak inhibitors
EP3544970B1 (en) 2016-11-22 2021-11-17 Dana-Farber Cancer Institute, Inc. Inhibitors of interleukin-1 receptor-associated kinases and uses thereof
IL268128B2 (en) * 2017-02-01 2023-03-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd n1-(4-(5-(cyclopropylmethyl)-1-methyl-1-h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or Iraki inhibitors for cancer therapy
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
EP3620457A4 (en) * 2017-05-02 2021-01-06 Korea Research Institute of Chemical Technology COMPOUND DERIVED FROM PYRIMIDINE, OPTICAL ISOMER, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING A TYRO 3-RELATED DISEASE, CONSIDERING IT AS AN ACTIVE INGREDIENT
CN111164069A (zh) * 2017-07-03 2020-05-15 葛兰素史密斯克莱知识产权发展有限公司 作为atf4抑制剂用于治疗癌症和其它疾病的n-(3-(2-(4-氯苯氧基)乙酰胺基)双环[1.1.1]戊-1-基)-2-环丁烷-1-甲酰胺衍生物以及相关化合物
BR112020001591A2 (pt) * 2017-08-09 2020-07-21 Denali Therapeutics Inc. compostos, composições e métodos
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EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
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