PL3362450T3 - N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej - Google Patents

N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej

Info

Publication number
PL3362450T3
PL3362450T3 PL16784435T PL16784435T PL3362450T3 PL 3362450 T3 PL3362450 T3 PL 3362450T3 PL 16784435 T PL16784435 T PL 16784435T PL 16784435 T PL16784435 T PL 16784435T PL 3362450 T3 PL3362450 T3 PL 3362450T3
Authority
PL
Poland
Prior art keywords
inhibitors
substituted
sibiriline
derivatives
cellular necroptosis
Prior art date
Application number
PL16784435T
Other languages
English (en)
Inventor
Marie-Thérèse DIMANCHE-BOITREL
Stéphane BACH
Claire DELEHOUZE
Peter Goekjian
Arnaud COMTE
Original Assignee
Institut National De La Santé Et De La Recherche Médicale (Inserm)
Centre National De La Recherche Scientifique (Cnrs)
Sorbonne Université
Universite Claude Bernard Lyon 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National De La Santé Et De La Recherche Médicale (Inserm), Centre National De La Recherche Scientifique (Cnrs), Sorbonne Université, Universite Claude Bernard Lyon 1 filed Critical Institut National De La Santé Et De La Recherche Médicale (Inserm)
Publication of PL3362450T3 publication Critical patent/PL3362450T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL16784435T 2015-10-13 2016-10-13 N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej PL3362450T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306623 2015-10-13
PCT/EP2016/074637 WO2017064216A1 (en) 2015-10-13 2016-10-13 N1- and n7-substituted sibiriline derivatives and their use as inhibitor of cellular necroptosis
EP16784435.6A EP3362450B1 (en) 2015-10-13 2016-10-13 N1- and n7-substituted sibiriline derivatives and their use as inhibitors of cellular necroptosis

Publications (1)

Publication Number Publication Date
PL3362450T3 true PL3362450T3 (pl) 2021-08-23

Family

ID=54337711

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16784435T PL3362450T3 (pl) 2015-10-13 2016-10-13 N1 i n7-podstawione pochodne sybiriliny oraz ich zastosowania jako inhibitory nekroptozy komórkowej

Country Status (6)

Country Link
US (1) US10457678B2 (pl)
EP (1) EP3362450B1 (pl)
DK (1) DK3362450T3 (pl)
ES (1) ES2821971T3 (pl)
PL (1) PL3362450T3 (pl)
WO (1) WO2017064216A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3362449T3 (da) * 2015-10-13 2021-07-19 Inst Nat Sante Rech Med Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose
CN111978311B (zh) * 2019-05-21 2024-05-31 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
JP2024506530A (ja) * 2021-01-25 2024-02-14 シービーライフ フェロトーシス制御性細胞死の阻害剤としてのインドール、６－および７－アザインドール誘導体の使用
WO2024115793A1 (en) 2022-12-02 2024-06-06 Seabelife Synergistic combinations of regulated necrosis inhibitors with n-acetylcysteine
WO2025078659A1 (en) 2023-10-12 2025-04-17 Seabelife Method and kit for inducing cell differentiation, and regulated necrotic cell death inhibitor for use for regenerating damaged tissues

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7132998A (en) * 1997-04-24 1998-11-13 Ortho-Mcneil Corporation, Inc. Substituted pyrrolopyridines useful in the treatment of inflammatory diseases
US7491743B2 (en) 2003-08-29 2009-02-17 President And Fellows Of Harvard College Inhibitors of cellular necrosis
US9180127B2 (en) 2009-12-29 2015-11-10 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
US9643977B2 (en) * 2011-03-11 2017-05-09 President And Fellows Of Harvard College Necroptosis inhibitors and methods of use therefor

Also Published As

Publication number Publication date
EP3362450B1 (en) 2020-07-01
WO2017064216A1 (en) 2017-04-20
EP3362450A1 (en) 2018-08-22
ES2821971T3 (es) 2021-04-28
DK3362450T3 (da) 2020-09-14
US20180312502A1 (en) 2018-11-01
US10457678B2 (en) 2019-10-29

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