SG11201605915WA - Furo-3-carboxamide derivatives and methods of use - Google Patents

Furo-3-carboxamide derivatives and methods of use

Info

Publication number
SG11201605915WA
SG11201605915WA SG11201605915WA SG11201605915WA SG11201605915WA SG 11201605915W A SG11201605915W A SG 11201605915WA SG 11201605915W A SG11201605915W A SG 11201605915WA SG 11201605915W A SG11201605915W A SG 11201605915WA SG 11201605915W A SG11201605915W A SG 11201605915WA
Authority
SG
Singapore
Prior art keywords
furo
methods
carboxamide derivatives
carboxamide
derivatives
Prior art date
Application number
SG11201605915WA
Inventor
Robert Altenbach
Huaqing Liu
Bruce Clapham
Ana Aguirre
Marlon Cowart
John Koenig
Katerina Sarris
Marc Scanio
Kerren Swinger
Anil Vasudevan
Clara Villamil
Kevin Woller
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of SG11201605915WA publication Critical patent/SG11201605915WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
SG11201605915WA 2014-01-24 2015-01-22 Furo-3-carboxamide derivatives and methods of use SG11201605915WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461931232P 2014-01-24 2014-01-24
PCT/US2015/012519 WO2015112754A1 (en) 2014-01-24 2015-01-22 Furo-3-carboxamide derivatives and methods of use

Publications (1)

Publication Number Publication Date
SG11201605915WA true SG11201605915WA (en) 2016-08-30

Family

ID=52469321

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201605915WA SG11201605915WA (en) 2014-01-24 2015-01-22 Furo-3-carboxamide derivatives and methods of use

Country Status (7)

Country Link
US (1) US9777020B2 (en)
EP (1) EP3097095A1 (en)
JP (1) JP2017508729A (en)
CA (1) CA2937074A1 (en)
MX (1) MX2016009621A (en)
SG (1) SG11201605915WA (en)
WO (1) WO2015112754A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017160930A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
EP3589637B1 (en) * 2017-03-02 2021-04-14 Eli Lilly and Company Compounds useful for inhibiting ror-gamma-t
PL3589638T3 (en) * 2017-03-02 2021-09-27 Eli Lilly And Company Compounds useful for inhibiting ror-gamma-t
CN107383026B (en) * 2017-06-29 2019-04-30 武汉药明康德新药开发有限公司 A kind of synthetic method of 7- methylol -2,5- diaza spiro [3,4] octane -2- t-butyl formate
TWI782056B (en) * 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 A fused ring derivative having a mgat2 inhibitoy activity
CN110563726A (en) * 2019-07-23 2019-12-13 上海合全药业股份有限公司 Preparation method of tert-butyl-7, 9-dioxy-2, 6-diazaspiro [4.5] decane-2-formic acid ester

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002243B1 (en) * 1997-11-13 2002-02-28 Пфайзер Продактс Инк. Method of synthesis of pyrrole amides
JP2004515491A (en) * 2000-12-04 2004-05-27 ファイザー・プロダクツ・インク Synthesis of condensed pyrrolecarboxamides
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
WO2009054468A1 (en) * 2007-10-24 2009-04-30 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
KR101483215B1 (en) * 2010-01-29 2015-01-16 한미약품 주식회사 Bicyclic heteroaryl derivatives having inhibitory activity for protein kinases
CN103534257A (en) * 2011-04-05 2014-01-22 辉瑞有限公司 Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases
WO2014078408A1 (en) * 2012-11-13 2014-05-22 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors

Also Published As

Publication number Publication date
MX2016009621A (en) 2016-11-17
EP3097095A1 (en) 2016-11-30
US9777020B2 (en) 2017-10-03
WO2015112754A1 (en) 2015-07-30
CA2937074A1 (en) 2015-07-30
JP2017508729A (en) 2017-03-30
US20150210720A1 (en) 2015-07-30

Similar Documents

Publication Publication Date Title
IL286316A (en) Novel micro-dystrophins and related methods of use
IL250415B (en) Anti-pdl- antibodies and methods of use thereof
HK1243102A1 (en) Anti-cd79b antibodies and methods of use
HRP20181359T1 (en) Anti-jagged1 antibodies and methods of use
PL3160498T3 (en) Il-15-based molecules and methods of use thereof
HK1253049A1 (en) Glycan-interacting compounds and methods of use
GB201421847D0 (en) Dispensers and methods of use thereof
IL251988A0 (en) Glycan-interacting compounds and methods of use
HRP20190432T1 (en) Pladienolide pyridine compounds and methods of use
IL253234A0 (en) Methods of transdifferentiation and methods of use thereof
GB201417048D0 (en) Occupancy-control device and methods of use
RS60718B1 (en) Compounds and methods of use
SG11201605915WA (en) Furo-3-carboxamide derivatives and methods of use
ZA201606450B (en) Compounds and their methods of use
HK1243404A1 (en) Tryptamide compositions and methods of use
GB2558547B (en) Actuatable paddle and methods of use
GB201403697D0 (en) Compounds and methods of use
GB201416797D0 (en) Contianer and method of use thereof