IT1153216B - Procedimento per la preparazione di composti cianoeterociclici - Google Patents

Procedimento per la preparazione di composti cianoeterociclici

Info

Publication number
IT1153216B
IT1153216B IT8223705A IT2370582A IT1153216B IT 1153216 B IT1153216 B IT 1153216B IT 8223705 A IT8223705 A IT 8223705A IT 2370582 A IT2370582 A IT 2370582A IT 1153216 B IT1153216 B IT 1153216B
Authority
IT
Italy
Prior art keywords
rest
atoms
aryl
carbon
alkyl
Prior art date
Application number
IT8223705A
Other languages
English (en)
Other versions
IT8223705A0 (it
Inventor
Helmut Vorbruggen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19813141640 external-priority patent/DE3141640A1/de
Priority claimed from DE19823231072 external-priority patent/DE3231072A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of IT8223705A0 publication Critical patent/IT8223705A0/it
Application granted granted Critical
Publication of IT1153216B publication Critical patent/IT1153216B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
IT8223705A 1981-10-16 1982-10-12 Procedimento per la preparazione di composti cianoeterociclici IT1153216B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813141640 DE3141640A1 (de) 1981-10-16 1981-10-16 Verfahren zur herstellung von cyanoheterocyclen
DE19823231072 DE3231072A1 (de) 1982-08-19 1982-08-19 Verfahren zur herstellung von cyanoheterocyclen

Publications (2)

Publication Number Publication Date
IT8223705A0 IT8223705A0 (it) 1982-10-12
IT1153216B true IT1153216B (it) 1987-01-14

Family

ID=25796795

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8223705A IT1153216B (it) 1981-10-16 1982-10-12 Procedimento per la preparazione di composti cianoeterociclici

Country Status (6)

Country Link
EP (1) EP0091464B1 (it)
JP (1) JPS58501723A (it)
AT (1) ATE19240T1 (it)
DE (1) DE3270662D1 (it)
IT (1) IT1153216B (it)
WO (1) WO1983001446A1 (it)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
KR20090017498A (ko) 2006-04-04 2009-02-18 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 Ｐｉ３ 키나제 길항물질
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
US8841312B2 (en) 2007-12-19 2014-09-23 Amgen Inc. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
SG10201605472WA (en) 2008-01-04 2016-09-29 Intellikine Llc Certain Chemical Entities, Compositions And Methods
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US8389533B2 (en) 2008-04-07 2013-03-05 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
KR20110039326A (ko) 2008-07-08 2011-04-15 인텔리카인, 인크. 키나제 억제제 및 사용 방법
EP2346508B1 (en) 2008-09-26 2016-08-24 Intellikine, LLC Heterocyclic kinase inhibitors
WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
WO2011146882A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
AR084824A1 (es) 2011-01-10 2013-06-26 Intellikine Inc Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
CN103491962B (zh) 2011-02-23 2016-10-12 因特利凯有限责任公司 激酶抑制剂的组合及其用途
PT2937349T (pt) 2011-03-23 2017-03-24 Amgen Inc Inibidores duais tricíclicos fusionados de cdk 4/6 e flt3
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
RU2014111823A (ru) 2011-08-29 2015-10-10 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения и их применения
CA2846496C (en) 2011-09-02 2020-07-14 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
KR20150061651A (ko) 2012-09-26 2015-06-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ire1의 조절
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MY175778A (en) 2013-10-04 2020-07-08 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
CN104725304B (zh) * 2013-12-18 2017-08-18 上海医药工业研究院 一种3‑取代‑2‑氰基吡啶类化合物的制备方法
SG11201607705XA (en) 2014-03-19 2016-10-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6980649B2 (ja) 2015-09-14 2021-12-15 インフィニティー ファーマシューティカルズ， インコーポレイテッド イソキノリノン誘導体の固体形態、それを製造する方法、それを含む組成物、及びそれを使用する方法
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3474856B1 (en) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Combination therapies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2991285A (en) * 1958-09-09 1961-07-04 Rohm & Haas Process of cyanation and nitriles produced thereby

Also Published As

Publication number Publication date
EP0091464B1 (de) 1986-04-16
DE3270662D1 (en) 1986-05-22
JPS58501723A (ja) 1983-10-13
EP0091464A1 (de) 1983-10-19
IT8223705A0 (it) 1982-10-12
ATE19240T1 (de) 1986-05-15
WO1983001446A1 (en) 1983-04-28

Similar Documents

Publication Publication Date Title
IT1153216B (it) Procedimento per la preparazione di composti cianoeterociclici
GR78508B (it)
JPS56154467A (en) Novel pyrimidine-2-sulfide compound
UA7228A1 (uk) Спосіб одержання похідних n-(4-індолілпіперідиноалкіл )бензімідазолону або їх солей з кислотами
GB8314696D0 (en) Compounds
SE8001818L (sv) Merkaptoacyldihydropyrazolkarboxylsyraderivat
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
DE69501487D1 (de) Herstellung von Thioamiden
ES469613A1 (es) Procedimiento para la obtencion de compuetos de fenilaceta- mida
DK0379085T3 (da) Phenylalkyminer og fungicider indeholdende disse
JPS57128674A (en) Growth regulant alpha-azolylglycol, manufacture and plant growth regulant containing same
ATE23993T1 (de) Verfahren zur herstellung von o,o'dithiobenzamiden.
ES8704158A1 (es) Procedimiento para la obtencion de derivados de diclorociclopropilalquilhidroxialquil-azol
SE8302084D0 (sv) New benzimidazole derivatives
HUT38948A (en) Process for preparing new isoxazolo-quinolinone derivatives and pharmaceutical compositions containing such compounds
LU88287I2 (fr) Cyproternacetate (Climen)
ATE66463T1 (de) 1,4-cyclohexandiamine, verfahren zu ihrer herstellung und ihre verwendung als fungizide.
ATE17851T1 (de) Imidazolylkarbonsaeure, deren derivate und herstellung.
ZA841975B (en) Phosphonic acid esters
GR3005867T3 (it)
ATE31404T1 (de) Verfahren zur herstellung von cycklopropanabkoemmlingen.
ATE66462T1 (de) 1,4-cyclohexandiamine, verfahren zu ihrer herstellung und ihre verwendung als fungizide.
ATE24720T1 (de) Verfahren zur herstellung von 5(6)-thiocyanobenzimidazol-derivaten.
ES482948A1 (es) Un procedimiento para la preparacion de derivados de oxadia-zolotriazona
ES8302712A1 (es) Un nuevo procedimiento de preparacion de imidazobenzodiazepinas.