MX348311B - Inhibidores nampt. - Google Patents

Inhibidores nampt.

Info

Publication number
MX348311B
MX348311B MX2014005730A MX2014005730A MX348311B MX 348311 B MX348311 B MX 348311B MX 2014005730 A MX2014005730 A MX 2014005730A MX 2014005730 A MX2014005730 A MX 2014005730A MX 348311 B MX348311 B MX 348311B
Authority
MX
Mexico
Prior art keywords
nampt
nampt inhibitors
compounds
inhibitors
inhibit
Prior art date
Application number
MX2014005730A
Other languages
English (en)
Other versions
MX2014005730A (es
Inventor
R Woller Kevin
L Curtin Michael
Vasudevan Anil
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2014005730A publication Critical patent/MX2014005730A/es
Publication of MX348311B publication Critical patent/MX348311B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/547—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame spiro-condensed or forming part of bridged ring systems
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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Abstract

Se describen compuestos que inhiben la actividad de NAMPT, composiciones que contienen a los compuestos y métodos para tratar enfermedades durante las cuales se expresa NAMPT.
MX2014005730A 2011-11-11 2011-11-11 Inhibidores nampt. MX348311B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2011/082108 WO2013067710A1 (en) 2011-11-11 2011-11-11 Nampt inhibitors

Publications (2)

Publication Number Publication Date
MX2014005730A MX2014005730A (es) 2014-10-13
MX348311B true MX348311B (es) 2017-06-06

Family

ID=48288470

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014005730A MX348311B (es) 2011-11-11 2011-11-11 Inhibidores nampt.

Country Status (6)

Country Link
US (1) US20160031813A1 (es)
EP (1) EP2776393B1 (es)
JP (1) JP5980340B2 (es)
CA (1) CA2855510A1 (es)
MX (1) MX348311B (es)
WO (1) WO2013067710A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10144742B2 (en) 2014-04-18 2018-12-04 Millennium Pharmaceuticals, Inc. Quinoxaline compounds and uses thereof
TW201625641A (zh) * 2014-05-22 2016-07-16 健臻公司 Ｎａｍｐｔ抑制劑及方法
JP2017521426A (ja) 2014-07-23 2017-08-03 オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ Ｎａｍｐｔ抑制物質としての４，５−ジヒドロイソオキサゾール誘導体
CN105601640B (zh) * 2014-11-19 2018-08-03 天津药明康德新药开发有限公司 一种n-叔丁氧羰基-7-（胺甲基）-6-氧杂-2-螺[4.5]癸烷的合成方法
WO2016118565A1 (en) 2015-01-20 2016-07-28 Millennium Pharmaceuticals, Inc. Quinazoline and quinoline compounds and uses thereof
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