BRPI0516915A - derivados de tiazol substituìdos por 5-carboxamido que interagem com canais de ìons, particularmante com canais de ìons da famìlia kv - Google Patents

derivados de tiazol substituìdos por 5-carboxamido que interagem com canais de ìons, particularmante com canais de ìons da famìlia kv

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Publication number
BRPI0516915A
BRPI0516915A BRPI0516915-1A BRPI0516915A BRPI0516915A BR PI0516915 A BRPI0516915 A BR PI0516915A BR PI0516915 A BRPI0516915 A BR PI0516915A BR PI0516915 A BRPI0516915 A BR PI0516915A
Authority
BR
Brazil
Prior art keywords
ion channels
interact
compounds
family
thiazole derivatives
Prior art date
Application number
BRPI0516915-1A
Other languages
English (en)
Inventor
Petra Blom
Jan Octaaf De Kerpel
Eric Pierre Paul Fourmaintraux
Titus Jan Kalleta
Dirk Leysen
Original Assignee
Devgen Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen Nv filed Critical Devgen Nv
Publication of BRPI0516915A publication Critical patent/BRPI0516915A/pt

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    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

DERIVADOS DE TIAZOL SUBSTITUIDOS POR 5- CARBOXAMIDO QUE INTERAGEM COM CANAIS DE ìONS, PARTICULARMENTE COM CANAIS DE ìONS DA Família Kv A presente invenção refere-se a compostos que interagem com canais de íons. Particularmente, a invenção refere-se a compostos que têm a fórmula estrutural (I), (II), (III) ou (IV), seus estereoisómeros, tautómeros, racêmicos, pró-medicamentos, metabólitos, ou um sal e/ou um solvato farmaceuticamente aceitáveis dos mesmos, em que X, Y¹, Y¹, R¹, n, R³, R¬8¬, R¬9¬ R¬10¬, L¹, L², Ar¹ e Ar² são definidos na reivindicação 1. A invenção também de refere aos métodos para a preparação dos ditos compostos, às composições farmacêuticas que compreendem os ditos compostos, e ao uso dos ditos compostos nos métodos para o tratamento do corpo de seres humanos e animais.
BRPI0516915-1A 2004-12-01 2005-12-01 derivados de tiazol substituìdos por 5-carboxamido que interagem com canais de ìons, particularmante com canais de ìons da famìlia kv BRPI0516915A (pt)

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US63207204P 2004-12-01 2004-12-01
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US68691205P 2005-06-03 2005-06-03
EP05077177 2005-09-22
PCT/EP2005/056390 WO2006058905A1 (en) 2004-12-01 2005-12-01 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY

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