FR2834295B1 - Cristaux de glucokinase et leurs methodes de culture - Google Patents

Cristaux de glucokinase et leurs methodes de culture

Info

Publication number
FR2834295B1
FR2834295B1 FR0216171A FR0216171A FR2834295B1 FR 2834295 B1 FR2834295 B1 FR 2834295B1 FR 0216171 A FR0216171 A FR 0216171A FR 0216171 A FR0216171 A FR 0216171A FR 2834295 B1 FR2834295 B1 FR 2834295B1
Authority
FR
France
Prior art keywords
glucokinase
crystals
culture
methods
glucokinase crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0216171A
Other languages
English (en)
Other versions
FR2834295A1 (fr
Inventor
Wendy Lea Corbett
Robert Lewis Crowther
Pete William Dunten
R Ursula Kammlott
Christine Maria Lukacs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2834295A1 publication Critical patent/FR2834295A1/fr
Application granted granted Critical
Publication of FR2834295B1 publication Critical patent/FR2834295B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
FR0216171A 2001-12-19 2002-12-19 Cristaux de glucokinase et leurs methodes de culture Expired - Fee Related FR2834295B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34198801P 2001-12-19 2001-12-19

Publications (2)

Publication Number Publication Date
FR2834295A1 FR2834295A1 (fr) 2003-07-04
FR2834295B1 true FR2834295B1 (fr) 2005-03-04

Family

ID=23339854

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0216171A Expired - Fee Related FR2834295B1 (fr) 2001-12-19 2002-12-19 Cristaux de glucokinase et leurs methodes de culture

Country Status (5)

Country Link
US (2) US6911545B2 (fr)
JP (1) JP3734472B2 (fr)
DE (1) DE10259786A1 (fr)
FR (1) FR2834295B1 (fr)
GB (1) GB2385328B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
AU2003235307A1 (en) * 2002-05-16 2003-12-02 Banyu Pharmaceutical Co., Ltd. Crystal of glucokinase protein, and method for drug design using the crystal
KR20050074959A (ko) 2002-10-03 2005-07-19 노파르티스 아게 제ｉｉ형 당뇨병 치료에 유용한 글루코키나아제 활성인자로서의 치환된 (티아졸-２-일)-아미드 또는 술폰아미드
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
PL378117A1 (pl) 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
JP4621198B2 (ja) * 2003-02-11 2011-01-26 プロシディオン・リミテッド トリ（シクロ）置換アミドグルコキナーゼ活性化化合物
US7781451B2 (en) * 2004-04-02 2010-08-24 Novartis Ag Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
PT1735322E (pt) 2004-04-02 2012-01-12 Novartis Ag Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2
TW200600086A (en) 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
MX2007004560A (es) 2004-10-16 2007-06-08 Astrazeneca Ab Proceso para hacer compuestos de fenoxi benzamida.
TW200714597A (en) 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
EP1902052B1 (fr) 2005-07-09 2012-11-28 AstraZeneca AB Dérivés d hétéroaryl benzamide utilisés en tant qu activateurs de la glk dans le traitement du diabète
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CA2624102A1 (fr) 2005-09-29 2007-04-12 Sanofi-Aventis Derives de phenyl-1,2,4-oxadiazolone : procedes de preparation et utilisation comme produits pharmaceutiques
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
WO2007051845A1 (fr) * 2005-11-03 2007-05-10 Prosidion Ltd Amides a substitution tricyclo
TW200738621A (en) 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
TW200825063A (en) 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US20100094009A1 (en) 2006-12-21 2010-04-15 Mccabe James Novel crystalline compound useful as glk activator
TW200831081A (en) 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
KR20090121376A (ko) * 2007-03-07 2009-11-25 교린 세이야꾸 가부시키 가이샤 글루코키나아제 활성화 물질
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
CL2009000004A1 (es) * 2008-01-15 2010-02-19 Lilly Co Eli Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia.
US20100311072A1 (en) * 2008-01-28 2010-12-09 Bristol-Myers Squibb Company Fluorescence polarization binding assay for characterizing glucokinase ligands
NZ588462A (en) 2008-04-28 2012-07-27 Kyorin Seiyaku Kk Cyclopentylacrylic acid amide derivative
KR20110052676A (ko) 2008-08-04 2011-05-18 아스트라제네카 아베 피라졸로[3,4]피리미딘-4-일 유도체 및 당뇨병 및 비만을 치료하기 위한 이의 용도
MY158896A (en) * 2008-12-10 2016-11-30 Univ Putra Malaysia Method for crystallizing geobacillus strain t1 polypeptide
GB0902406D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
GB0902434D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
AR076221A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
JP2014064048A (ja) 2011-01-27 2014-04-10 Panasonic Corp ネットワーク制御システム、ネットワーク制御機器、ネットワーク被制御機器及び機器制御方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320050B1 (en) * 1999-03-29 2001-11-20 Hoffmann-La Roche Inc. Heteroaromatic glucokinase activators
CA2368347C (fr) * 1999-03-29 2007-05-22 F. Hoffmann-La Roche Ag Activateurs de glucokinase
ATE286036T1 (de) 2000-05-03 2005-01-15 Hoffmann La Roche Heteroaromatische alkynylphenyl-verbindungen als glukokinase-aktivatoren
ES2307623T3 (es) 2000-05-08 2008-12-01 F. Hoffmann-La Roche Ag Activadores de fenilamida glucokinasa para-amina sustituida.
KR100548901B1 (ko) 2000-05-08 2006-02-02 에프. 호프만-라 로슈 아게 치환된 페닐아세트아미드 및 그의 글루코키나제활성화제로서의 용도
WO2001090301A2 (fr) * 2000-05-17 2001-11-29 Princeton University Procedes de preparation de modeles, procedes d'utilisation des modeles de la proteine murg, composes liant, inhibant ou stimulant des proteines murg et des compositions therapeutiques associees
AU2003221140B9 (en) 2002-03-26 2009-07-30 Banyu Pharmaceutical Co., Ltd. Novel aminobenzamide derivative

Also Published As

Publication number Publication date
GB0229456D0 (en) 2003-01-22
US7534593B2 (en) 2009-05-19
US20030219887A1 (en) 2003-11-27
GB2385328A (en) 2003-08-20
JP2003235551A (ja) 2003-08-26
US6911545B2 (en) 2005-06-28
US20060141599A1 (en) 2006-06-29
JP3734472B2 (ja) 2006-01-11
DE10259786A1 (de) 2003-07-17
FR2834295A1 (fr) 2003-07-04
GB2385328B (en) 2005-09-21

Similar Documents

Publication Publication Date Title
FR2834295B1 (fr) Cristaux de glucokinase et leurs methodes de culture
FR19C1053I2 (fr) Inhibiteurs de co-transporteur 2 de sodium glucose et procedes d'utilisation de ceux-ci
NO20041160L (no) Bio-avlesningsplattform for pavisning og kvantitering av biologiske molekyler
NO20041582L (no) Antistoffinhibitorer av GDF-8 og anvendelse derav
DK1148875T3 (da) Fremgangsmåder og sammensætninger til forögelse af antallet af hvide blodlegemer
DE60218695D1 (de) Biosensoren und messverfahren
ATE370938T1 (de) Pro-pharmakon von cox-2-inhibitoren
NO20011121D0 (no) FremgangsmÕte for formasjonsbehandling med deformerbare partikler
DK1323222T3 (da) Önet og fremgangsmåde til drift af et önet
NO20040873L (no) Fremgangsmate og anordning for sammensetting av gjenfestbare absorberende klesplagg
DK1667986T3 (da) Acetonesolvat af dimethoxydocetaxel og fremgangsmåde til fremstilling heraf
DK1750713T3 (da) Anvendelse af imatinib til behandling af leversygdomme og vi-rusinfektioner
DK1726658T3 (da) Fremgangsmåde til fremstilling af dihydroxyestere og derivater deraf
NO20053874D0 (no) Formulering og metoder for behandling av thrombocytemi
NO20033854D0 (no) N-but-3-enyl-norbuprenorfin og fremgangsmåter for anvendelse
IS8497A (is) Aðferðir og hvarfefni til að meðhöndla bólgusjúkdóma
NO20041004L (no) Fremgangsmate og anordning for sammensetting av gjenfestbare absorberende klesplagg
DK1411926T3 (da) Integrininhibitorer til behandling af öjensygdomme
DK1381382T3 (da) Fremgangsmåder og præparater til behandling af öjensygdomme
NO20030843D0 (no) Anordning og fremgangsmåte for kultivering
NO20033506L (no) Parasitticidale preparater og metoder for anvendelse
ITTO20010848A0 (it) Disposizione e metodo di purificazione o trattamento elettrochimico.
DK1572180T3 (da) Anvendelse af alfa-phenylthiocarboxylsyrer med serumglucose-sænkende og serumlipid-sænkende virkning
NO20023737L (no) Fremgangsmåte og preparater for behandling av en inflammatorisk lidelse
FR2856193B1 (fr) Tranche soi et procede de preparation

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20110831