ATE298758T1 - Kristalline freie base von clindamycin - Google Patents

Kristalline freie base von clindamycin

Info

Publication number
ATE298758T1
ATE298758T1 AT02768713T AT02768713T ATE298758T1 AT E298758 T1 ATE298758 T1 AT E298758T1 AT 02768713 T AT02768713 T AT 02768713T AT 02768713 T AT02768713 T AT 02768713T AT E298758 T1 ATE298758 T1 AT E298758T1
Authority
AT
Austria
Prior art keywords
clindamycin
crystalline freebase
freebase
crystalline
Prior art date
Application number
AT02768713T
Other languages
English (en)
Inventor
Robert S Chao
Michael Hawley
Lisa M Reeder
Donald P Jones
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE298758T1 publication Critical patent/ATE298758T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
AT02768713T 2001-08-28 2002-08-26 Kristalline freie base von clindamycin ATE298758T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31537501P 2001-08-28 2001-08-28
US37789202P 2002-05-01 2002-05-01
PCT/US2002/027159 WO2003020736A1 (en) 2001-08-28 2002-08-26 Crystaline clindamycin free base

Publications (1)

Publication Number Publication Date
ATE298758T1 true ATE298758T1 (de) 2005-07-15

Family

ID=26979857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02768713T ATE298758T1 (de) 2001-08-28 2002-08-26 Kristalline freie base von clindamycin

Country Status (13)

Country Link
US (4) US20030073647A1 (de)
EP (1) EP1421093B1 (de)
JP (1) JP2005504785A (de)
AR (1) AR037654A1 (de)
AT (1) ATE298758T1 (de)
BR (1) BR0212214A (de)
CA (1) CA2458644A1 (de)
DE (1) DE60204897T2 (de)
ES (1) ES2243763T3 (de)
MX (1) MXPA04001964A (de)
MY (1) MY134083A (de)
TW (1) TWI232865B (de)
WO (1) WO2003020736A1 (de)

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US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
AU2003284942A1 (en) * 2002-10-30 2004-06-07 Pharmacia Corporation Oral extended release tablets and methods of making and using the same
WO2004087175A1 (en) * 2003-04-04 2004-10-14 Pharmacia Corporation Oral extended release compressed tablets of multiparticulates
WO2005009365A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533292C (en) * 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1648418A4 (de) * 2003-07-21 2011-11-16 Middlebrook Pharmaceuticals Inc Antibiotisches produkt, seine verwendung und formulierung
US8758820B2 (en) * 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
CA2535780A1 (en) 2003-08-29 2005-03-17 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
AU2004273830B2 (en) 2003-09-15 2011-03-24 Shionogi, Inc. Antibiotic product, use and formulation thereof
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
EP1771158A4 (de) 2004-07-02 2008-03-12 Advancis Pharmaceutical Corp Tablette für pulsierte abgabe
US7976517B2 (en) * 2004-09-30 2011-07-12 Codman & Shurtleff, Inc. Fluid management flow implants of improved occlusion resistance
CN100446774C (zh) * 2005-05-31 2008-12-31 黑龙江龙桂制药有限公司 盐酸克林霉素阴道泡腾片及其制备方法
JP4892915B2 (ja) * 2005-10-04 2012-03-07 大日本印刷株式会社 エパルレスタット製造法
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2009015197A1 (en) * 2007-07-24 2009-01-29 University Of Memphis Research Foundation Local delivery method and composition
WO2010010568A1 (en) * 2008-07-22 2010-01-28 Lupin Limited Oral compositions of clindamycin
CN111825729B (zh) * 2020-07-14 2023-08-29 天方药业有限公司 克林霉素磷酸酯的纯化方法
CN112206212B (zh) * 2020-10-16 2023-04-28 海南锦瑞制药有限公司 一种注射用克林霉素磷酸酯的制备方法
CN112569196B (zh) * 2020-12-30 2023-05-12 海南海神同洲制药有限公司 一种克林霉素磷酸酯阴道片及其制备工艺

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US3380992A (en) * 1965-06-14 1968-04-30 Upjohn Co Lincomycin derivatives and process for preparing same
NL126594C (de) * 1964-09-12
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3508904A (en) * 1965-04-29 1970-04-28 Owens Illinois Inc Glass feeding orifice with multichamber combustion zones
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3426012A (en) * 1966-04-01 1969-02-04 Upjohn Co Process for preparing lincomycin-2-acylates and novel intermediate compounds
US3395139A (en) * 1966-06-17 1968-07-30 Upjohn Co Lincomycin s and process for producing the same
US3487068A (en) * 1966-12-16 1969-12-30 Upjohn Co Lincomycin-2-phosphates,7-substituted compounds and salts thereof
US3475407A (en) * 1967-12-22 1969-10-28 Upjohn Co Process for preparing 7(r)- and 7(s)-halolincomycins
US3726858A (en) * 1968-01-09 1973-04-10 Upjohn Co Delta 4',alpha-analogs of lincomycin
US3514440A (en) * 1968-01-23 1970-05-26 Upjohn Co 7-epimers of lincomycin and related compounds and processes for making the same
US3544551A (en) * 1968-04-30 1970-12-01 Upjohn Co 7-mercapto-7-deoxylincomycins and process for preparing the same
US3509127A (en) * 1968-04-30 1970-04-28 Upjohn Co Isologs of lincomycins and process for preparing the same
US3513155A (en) * 1968-05-07 1970-05-19 Upjohn Co Sulfoxides of 7-halo-7-deoxylincomycins and process
US3580904A (en) * 1969-04-03 1971-05-25 Upjohn Co 7-halo-7-deoxy-lincomycin derivatives
BE758393A (fr) * 1969-11-03 1971-05-03 Upjohn Co Procede de preparation de cis-1-thioglucosides et nouveaux produits en derivant
US3702322A (en) * 1970-04-06 1972-11-07 Upjohn Co Derivatives of lincomycin and its analogs and process
US3705889A (en) * 1970-04-28 1972-12-12 Upjohn Co Lincomycin analogs and process
US3714141A (en) * 1970-05-26 1973-01-30 Upjohn Co Process for making 7-halolincomycins
US3655885A (en) * 1970-06-10 1972-04-11 Upjohn Co Antibacterial compositions and methods of treating bacterial infections
US3715346A (en) * 1970-11-18 1973-02-06 Upjohn Co Process for the preparation of lincomycin compounds
US3671647A (en) * 1971-03-24 1972-06-20 Upjohn Co Lincomycin 3-nucleotides and the salts thereof
US3892729A (en) * 1971-06-23 1975-07-01 Upjohn Co 1{40 (Beta-hydroxyethyl)-1{40 -demethyl clindamycin 2-phosphates
US3892730A (en) * 1971-06-23 1975-07-01 Upjohn Co 1{40 -({62 -hydroxyethyl)-1{40 -demethyl clindamycin 2-acylates
US3915954A (en) * 1971-11-15 1975-10-28 Upjohn Co Derivatives of lincomycin and its analogs and process
US3853843A (en) * 1972-12-13 1974-12-10 Upjohn Co Derivatives of thiolincosaminide compounds
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US4278789A (en) * 1979-11-23 1981-07-14 The Upjohn Company Lincomycin compounds
US4310660A (en) * 1980-05-19 1982-01-12 The Upjohn Company Lincomycin compounds
US4309533A (en) * 1980-05-19 1982-01-05 The Upjohn Company Lincomycin compounds
US4317903A (en) * 1981-01-26 1982-03-02 The Upjohn Company Process for the purification of lincomycin
US4464466A (en) * 1981-04-20 1984-08-07 The Upjohn Company Process of producing lincomycin nucleotides
US4568741A (en) * 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
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US4895934A (en) * 1988-08-22 1990-01-23 E. I. Du Pont De Nemours And Company Process for the preparation of clindamycin phosphate
US4849515A (en) * 1988-08-22 1989-07-18 E. I. Du Pont De Nemours And Company Clindamycin-2-phosphoryl benzylate
US5182374A (en) * 1990-03-21 1993-01-26 American Cyanamid Company Clindamycin phosphate synthesis
US5811547A (en) * 1992-10-14 1998-09-22 Nippon Shinyaju Co., Ltd. Method for inducing crystalline state transition in medicinal substance
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DE19737348C2 (de) * 1997-08-27 2002-07-25 Dan-Gabriel Vulpescu Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung
DE69934582T2 (de) * 1998-06-11 2007-10-04 Pharmacia & Upjohn Co. Llc, Kalamazoo Delavirdin tablettenformulierung
EP1884520A3 (de) * 1999-12-15 2008-03-05 Cubist Pharmaceuticals, Inc. Daptomycin Analoge und deren Verwendung als antibakterielle Verbindungen

Also Published As

Publication number Publication date
BR0212214A (pt) 2004-10-19
WO2003020736A1 (en) 2003-03-13
AR037654A1 (es) 2004-12-01
MY134083A (en) 2007-11-30
US20030073648A1 (en) 2003-04-17
ES2243763T3 (es) 2005-12-01
TWI232865B (en) 2005-05-21
JP2005504785A (ja) 2005-02-17
EP1421093A1 (de) 2004-05-26
DE60204897T2 (de) 2006-05-11
CA2458644A1 (en) 2003-03-13
EP1421093B1 (de) 2005-06-29
US20030073826A1 (en) 2003-04-17
MXPA04001964A (es) 2004-06-07
US20050192236A1 (en) 2005-09-01
US20030073647A1 (en) 2003-04-17
DE60204897D1 (de) 2005-08-04

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties