AR037654A1 - Base libre de clindamicina sustancialmente cristalina, sustancia droga, composicion farmaceutica y su uso en la fabricacion de un medicamento y proceso para preparar dicha base libre cristalina de clindamicina - Google Patents
Base libre de clindamicina sustancialmente cristalina, sustancia droga, composicion farmaceutica y su uso en la fabricacion de un medicamento y proceso para preparar dicha base libre cristalina de clindamicinaInfo
- Publication number
- AR037654A1 AR037654A1 ARP020103235A ARP020103235A AR037654A1 AR 037654 A1 AR037654 A1 AR 037654A1 AR P020103235 A ARP020103235 A AR P020103235A AR P020103235 A ARP020103235 A AR P020103235A AR 037654 A1 AR037654 A1 AR 037654A1
- Authority
- AR
- Argentina
- Prior art keywords
- base
- free
- clindamycin
- manufacture
- clindamycine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporciona el antibiótico clindamicina en forma de base libre cristalina, de fórmula (1). Se revelan tres formas polimórficas/pseudopolimórficas de base libre cristalina de clindamicina. También se proporcionan composiciones farmacéuticas que comprenden base libre cristalina de clindamicina. También se proporcionan procesos para preparar base libre cristalina de clindamicina y composiciones de los mismos, así como su uso en la fabricación de un medicamento para tratar una amplia variedad de infecciones bacterianas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31537501P | 2001-08-28 | 2001-08-28 | |
US37789202P | 2002-05-01 | 2002-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037654A1 true AR037654A1 (es) | 2004-12-01 |
Family
ID=26979857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020103235A AR037654A1 (es) | 2001-08-28 | 2002-08-28 | Base libre de clindamicina sustancialmente cristalina, sustancia droga, composicion farmaceutica y su uso en la fabricacion de un medicamento y proceso para preparar dicha base libre cristalina de clindamicina |
Country Status (13)
Country | Link |
---|---|
US (4) | US20030073826A1 (es) |
EP (1) | EP1421093B1 (es) |
JP (1) | JP2005504785A (es) |
AR (1) | AR037654A1 (es) |
AT (1) | ATE298758T1 (es) |
BR (1) | BR0212214A (es) |
CA (1) | CA2458644A1 (es) |
DE (1) | DE60204897T2 (es) |
ES (1) | ES2243763T3 (es) |
MX (1) | MXPA04001964A (es) |
MY (1) | MY134083A (es) |
TW (1) | TWI232865B (es) |
WO (1) | WO2003020736A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
JP2006507298A (ja) * | 2002-10-30 | 2006-03-02 | ファルマシア コーポレーション | 経口持続放出型錠剤、ならびにその製造法および使用法 |
BRPI0408999A (pt) * | 2003-04-04 | 2006-03-28 | Pharmacia Corp | comprimidos prensados de multiparticulados de liberação oral prolongada |
JP2006528190A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
JP2006528185A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
JP2006528189A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質産物、その使用法および製剤 |
WO2005016311A1 (en) * | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
CA2535780A1 (en) | 2003-08-29 | 2005-03-17 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
JP2007513869A (ja) | 2003-09-15 | 2007-05-31 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
CA2550983C (en) * | 2003-12-24 | 2013-09-17 | Advancis Pharmaceutical Corporation | Enhanced absorption of modified release dosage forms |
JP2008505124A (ja) | 2004-07-02 | 2008-02-21 | アドバンシス ファーマスーティカル コーポレイション | パルス送達用錠剤 |
US7976517B2 (en) * | 2004-09-30 | 2011-07-12 | Codman & Shurtleff, Inc. | Fluid management flow implants of improved occlusion resistance |
CN100446774C (zh) * | 2005-05-31 | 2008-12-31 | 黑龙江龙桂制药有限公司 | 盐酸克林霉素阴道泡腾片及其制备方法 |
JP4892915B2 (ja) * | 2005-10-04 | 2012-03-07 | 大日本印刷株式会社 | エパルレスタット製造法 |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
US7923021B2 (en) * | 2007-07-24 | 2011-04-12 | University Of Memphis Research Foundation | Local delivery method and composition |
US9040089B2 (en) * | 2008-07-22 | 2015-05-26 | Lupin Limited | Oral compositions of clindamycin |
CN111825729B (zh) * | 2020-07-14 | 2023-08-29 | 天方药业有限公司 | 克林霉素磷酸酯的纯化方法 |
CN112206212B (zh) * | 2020-10-16 | 2023-04-28 | 海南锦瑞制药有限公司 | 一种注射用克林霉素磷酸酯的制备方法 |
CN112569196B (zh) * | 2020-12-30 | 2023-05-12 | 海南海神同洲制药有限公司 | 一种克林霉素磷酸酯阴道片及其制备工艺 |
Family Cites Families (47)
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US3380992A (en) * | 1965-06-14 | 1968-04-30 | Upjohn Co | Lincomycin derivatives and process for preparing same |
NL126594C (es) * | 1964-09-12 | |||
US3496163A (en) * | 1965-02-08 | 1970-02-17 | Upjohn Co | 7-halo-7-deoxylincomycins and process for preparing the same |
US3508904A (en) * | 1965-04-29 | 1970-04-28 | Owens Illinois Inc | Glass feeding orifice with multichamber combustion zones |
US3435025A (en) * | 1966-03-18 | 1969-03-25 | Upjohn Co | 7-deoxylincomycin and analogs and isomers thereof and process for making the same |
US3426012A (en) * | 1966-04-01 | 1969-02-04 | Upjohn Co | Process for preparing lincomycin-2-acylates and novel intermediate compounds |
US3395139A (en) * | 1966-06-17 | 1968-07-30 | Upjohn Co | Lincomycin s and process for producing the same |
US3487068A (en) * | 1966-12-16 | 1969-12-30 | Upjohn Co | Lincomycin-2-phosphates,7-substituted compounds and salts thereof |
US3475407A (en) * | 1967-12-22 | 1969-10-28 | Upjohn Co | Process for preparing 7(r)- and 7(s)-halolincomycins |
US3726858A (en) * | 1968-01-09 | 1973-04-10 | Upjohn Co | Delta 4',alpha-analogs of lincomycin |
US3514440A (en) * | 1968-01-23 | 1970-05-26 | Upjohn Co | 7-epimers of lincomycin and related compounds and processes for making the same |
US3544551A (en) * | 1968-04-30 | 1970-12-01 | Upjohn Co | 7-mercapto-7-deoxylincomycins and process for preparing the same |
US3509127A (en) * | 1968-04-30 | 1970-04-28 | Upjohn Co | Isologs of lincomycins and process for preparing the same |
US3513155A (en) * | 1968-05-07 | 1970-05-19 | Upjohn Co | Sulfoxides of 7-halo-7-deoxylincomycins and process |
US3580904A (en) * | 1969-04-03 | 1971-05-25 | Upjohn Co | 7-halo-7-deoxy-lincomycin derivatives |
BE758393A (fr) * | 1969-11-03 | 1971-05-03 | Upjohn Co | Procede de preparation de cis-1-thioglucosides et nouveaux produits en derivant |
US3702322A (en) * | 1970-04-06 | 1972-11-07 | Upjohn Co | Derivatives of lincomycin and its analogs and process |
US3705889A (en) * | 1970-04-28 | 1972-12-12 | Upjohn Co | Lincomycin analogs and process |
US3714141A (en) * | 1970-05-26 | 1973-01-30 | Upjohn Co | Process for making 7-halolincomycins |
US3655885A (en) * | 1970-06-10 | 1972-04-11 | Upjohn Co | Antibacterial compositions and methods of treating bacterial infections |
US3715346A (en) * | 1970-11-18 | 1973-02-06 | Upjohn Co | Process for the preparation of lincomycin compounds |
US3671647A (en) * | 1971-03-24 | 1972-06-20 | Upjohn Co | Lincomycin 3-nucleotides and the salts thereof |
US3892729A (en) * | 1971-06-23 | 1975-07-01 | Upjohn Co | 1{40 (Beta-hydroxyethyl)-1{40 -demethyl clindamycin 2-phosphates |
US3892730A (en) * | 1971-06-23 | 1975-07-01 | Upjohn Co | 1{40 -({62 -hydroxyethyl)-1{40 -demethyl clindamycin 2-acylates |
US3915954A (en) * | 1971-11-15 | 1975-10-28 | Upjohn Co | Derivatives of lincomycin and its analogs and process |
US3853843A (en) * | 1972-12-13 | 1974-12-10 | Upjohn Co | Derivatives of thiolincosaminide compounds |
US3870699A (en) * | 1973-03-06 | 1975-03-11 | Upjohn Co | Lincomycin analogs |
US4271266A (en) * | 1974-06-10 | 1981-06-02 | The Upjohn Manufacturing Company | Process for preparing lincomycin |
US3969516A (en) * | 1974-12-19 | 1976-07-13 | Nelson Research & Development Company | Composition and method for treatment of acne |
US4031304A (en) * | 1976-01-30 | 1977-06-21 | The Upjohn Company | Process for preparing lincomycin derivatives |
US4278789A (en) * | 1979-11-23 | 1981-07-14 | The Upjohn Company | Lincomycin compounds |
US4309533A (en) * | 1980-05-19 | 1982-01-05 | The Upjohn Company | Lincomycin compounds |
US4310660A (en) * | 1980-05-19 | 1982-01-12 | The Upjohn Company | Lincomycin compounds |
US4317903A (en) * | 1981-01-26 | 1982-03-02 | The Upjohn Company | Process for the purification of lincomycin |
US4464466A (en) * | 1981-04-20 | 1984-08-07 | The Upjohn Company | Process of producing lincomycin nucleotides |
US4568741A (en) * | 1984-05-15 | 1986-02-04 | The Upjohn Company | Synthesis of 7-halo-7-deoxylincomycins |
CN1004002B (zh) * | 1984-11-29 | 1989-04-26 | 厄普约翰公司 | 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 |
US4857337A (en) * | 1988-05-24 | 1989-08-15 | American Home Products Corp. (Del) | Enteric coated aspirin tablets |
US4849515A (en) * | 1988-08-22 | 1989-07-18 | E. I. Du Pont De Nemours And Company | Clindamycin-2-phosphoryl benzylate |
US4895934A (en) * | 1988-08-22 | 1990-01-23 | E. I. Du Pont De Nemours And Company | Process for the preparation of clindamycin phosphate |
US5182374A (en) * | 1990-03-21 | 1993-01-26 | American Cyanamid Company | Clindamycin phosphate synthesis |
US5811547A (en) * | 1992-10-14 | 1998-09-22 | Nippon Shinyaju Co., Ltd. | Method for inducing crystalline state transition in medicinal substance |
US6224911B1 (en) * | 1993-03-16 | 2001-05-01 | Syntex (U.S.A.) Llc | Process for the preparation of enteric coated pharmaceutical dosage forms |
US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
DE19737348C2 (de) * | 1997-08-27 | 2002-07-25 | Dan-Gabriel Vulpescu | Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung |
EA004311B1 (ru) * | 1998-06-11 | 2004-02-26 | Фармация Энд Апджон Компани | Таблетированная фармацевтическая композиция непролонгированного действия |
BR0017026A (pt) * | 1999-12-15 | 2003-01-07 | Cubist Pharm Inc | Lipeptìdeos como agentes antibacterianos |
-
2002
- 2002-08-26 US US10/227,902 patent/US20030073826A1/en not_active Abandoned
- 2002-08-26 BR BR0212214-6A patent/BR0212214A/pt not_active IP Right Cessation
- 2002-08-26 EP EP02768713A patent/EP1421093B1/en not_active Expired - Lifetime
- 2002-08-26 US US10/228,356 patent/US20030073648A1/en not_active Abandoned
- 2002-08-26 WO PCT/US2002/027159 patent/WO2003020736A1/en active IP Right Grant
- 2002-08-26 AT AT02768713T patent/ATE298758T1/de not_active IP Right Cessation
- 2002-08-26 US US10/227,901 patent/US20030073647A1/en not_active Abandoned
- 2002-08-26 DE DE60204897T patent/DE60204897T2/de not_active Expired - Fee Related
- 2002-08-26 CA CA002458644A patent/CA2458644A1/en not_active Abandoned
- 2002-08-26 MX MXPA04001964A patent/MXPA04001964A/es unknown
- 2002-08-26 ES ES02768713T patent/ES2243763T3/es not_active Expired - Lifetime
- 2002-08-26 JP JP2003525006A patent/JP2005504785A/ja active Pending
- 2002-08-27 MY MYPI20023184A patent/MY134083A/en unknown
- 2002-08-28 AR ARP020103235A patent/AR037654A1/es unknown
- 2002-08-28 TW TW091119546A patent/TWI232865B/zh not_active IP Right Cessation
-
2005
- 2005-05-02 US US11/120,264 patent/US20050192236A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR0212214A (pt) | 2004-10-19 |
MXPA04001964A (es) | 2004-06-07 |
ES2243763T3 (es) | 2005-12-01 |
EP1421093A1 (en) | 2004-05-26 |
MY134083A (en) | 2007-11-30 |
US20030073647A1 (en) | 2003-04-17 |
DE60204897T2 (de) | 2006-05-11 |
ATE298758T1 (de) | 2005-07-15 |
US20030073648A1 (en) | 2003-04-17 |
DE60204897D1 (de) | 2005-08-04 |
EP1421093B1 (en) | 2005-06-29 |
TWI232865B (en) | 2005-05-21 |
JP2005504785A (ja) | 2005-02-17 |
CA2458644A1 (en) | 2003-03-13 |
US20050192236A1 (en) | 2005-09-01 |
WO2003020736A1 (en) | 2003-03-13 |
US20030073826A1 (en) | 2003-04-17 |
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