DE60204897D1 - Kristalline freie base von clindamycin - Google Patents

Kristalline freie base von clindamycin

Info

Publication number
DE60204897D1
DE60204897D1 DE60204897T DE60204897T DE60204897D1 DE 60204897 D1 DE60204897 D1 DE 60204897D1 DE 60204897 T DE60204897 T DE 60204897T DE 60204897 T DE60204897 T DE 60204897T DE 60204897 D1 DE60204897 D1 DE 60204897D1
Authority
DE
Germany
Prior art keywords
clindamycin
free base
crystalline free
crystalline
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60204897T
Other languages
English (en)
Other versions
DE60204897T2 (de
Inventor
S Chao
Michael Hawley
M Reeder
P Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of DE60204897D1 publication Critical patent/DE60204897D1/de
Application granted granted Critical
Publication of DE60204897T2 publication Critical patent/DE60204897T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
DE60204897T 2001-08-28 2002-08-26 Kristalline freie base von clindamycin Expired - Fee Related DE60204897T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31537501P 2001-08-28 2001-08-28
US315375P 2001-08-28
US37789202P 2002-05-01 2002-05-01
US377892P 2002-05-01
PCT/US2002/027159 WO2003020736A1 (en) 2001-08-28 2002-08-26 Crystaline clindamycin free base

Publications (2)

Publication Number Publication Date
DE60204897D1 true DE60204897D1 (de) 2005-08-04
DE60204897T2 DE60204897T2 (de) 2006-05-11

Family

ID=26979857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60204897T Expired - Fee Related DE60204897T2 (de) 2001-08-28 2002-08-26 Kristalline freie base von clindamycin

Country Status (13)

Country Link
US (4) US20030073647A1 (de)
EP (1) EP1421093B1 (de)
JP (1) JP2005504785A (de)
AR (1) AR037654A1 (de)
AT (1) ATE298758T1 (de)
BR (1) BR0212214A (de)
CA (1) CA2458644A1 (de)
DE (1) DE60204897T2 (de)
ES (1) ES2243763T3 (de)
MX (1) MXPA04001964A (de)
MY (1) MY134083A (de)
TW (1) TWI232865B (de)
WO (1) WO2003020736A1 (de)

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US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
AU2003284942A1 (en) * 2002-10-30 2004-06-07 Pharmacia Corporation Oral extended release tablets and methods of making and using the same
MXPA05010636A (es) * 2003-04-04 2005-12-12 Pharmacia Corp Comprimidos de multiparticulas preparados por compresion de liberacion oral prolongada.
CA2533178C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533292C (en) * 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009364A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005016311A1 (en) * 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
AU2004264356B2 (en) 2003-08-12 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP5686494B2 (ja) 2003-08-29 2015-03-18 シオノギ インコーポレイテッド 抗生物質製剤、その使用法及び作成方法
EP1663169A4 (de) 2003-09-15 2010-11-24 Middlebrook Pharmaceuticals In Antibiotisches produkt, seine verwendung und formulierung
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
JP2008505124A (ja) 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
US7976517B2 (en) * 2004-09-30 2011-07-12 Codman & Shurtleff, Inc. Fluid management flow implants of improved occlusion resistance
CN100446774C (zh) * 2005-05-31 2008-12-31 黑龙江龙桂制药有限公司 盐酸克林霉素阴道泡腾片及其制备方法
JP4892915B2 (ja) * 2005-10-04 2012-03-07 大日本印刷株式会社 エパルレスタット製造法
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US7923021B2 (en) * 2007-07-24 2011-04-12 University Of Memphis Research Foundation Local delivery method and composition
US9040089B2 (en) * 2008-07-22 2015-05-26 Lupin Limited Oral compositions of clindamycin
CN111825729B (zh) * 2020-07-14 2023-08-29 天方药业有限公司 克林霉素磷酸酯的纯化方法
CN112206212B (zh) * 2020-10-16 2023-04-28 海南锦瑞制药有限公司 一种注射用克林霉素磷酸酯的制备方法
CN112569196B (zh) * 2020-12-30 2023-05-12 海南海神同洲制药有限公司 一种克林霉素磷酸酯阴道片及其制备工艺

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US3380992A (en) * 1965-06-14 1968-04-30 Upjohn Co Lincomycin derivatives and process for preparing same
NL126594C (de) * 1964-09-12
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3508904A (en) * 1965-04-29 1970-04-28 Owens Illinois Inc Glass feeding orifice with multichamber combustion zones
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3426012A (en) * 1966-04-01 1969-02-04 Upjohn Co Process for preparing lincomycin-2-acylates and novel intermediate compounds
US3395139A (en) * 1966-06-17 1968-07-30 Upjohn Co Lincomycin s and process for producing the same
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US3544551A (en) * 1968-04-30 1970-12-01 Upjohn Co 7-mercapto-7-deoxylincomycins and process for preparing the same
US3509127A (en) * 1968-04-30 1970-04-28 Upjohn Co Isologs of lincomycins and process for preparing the same
US3513155A (en) * 1968-05-07 1970-05-19 Upjohn Co Sulfoxides of 7-halo-7-deoxylincomycins and process
US3580904A (en) * 1969-04-03 1971-05-25 Upjohn Co 7-halo-7-deoxy-lincomycin derivatives
BE758393A (fr) * 1969-11-03 1971-05-03 Upjohn Co Procede de preparation de cis-1-thioglucosides et nouveaux produits en derivant
US3702322A (en) * 1970-04-06 1972-11-07 Upjohn Co Derivatives of lincomycin and its analogs and process
US3705889A (en) * 1970-04-28 1972-12-12 Upjohn Co Lincomycin analogs and process
US3714141A (en) * 1970-05-26 1973-01-30 Upjohn Co Process for making 7-halolincomycins
US3655885A (en) * 1970-06-10 1972-04-11 Upjohn Co Antibacterial compositions and methods of treating bacterial infections
US3715346A (en) * 1970-11-18 1973-02-06 Upjohn Co Process for the preparation of lincomycin compounds
US3671647A (en) * 1971-03-24 1972-06-20 Upjohn Co Lincomycin 3-nucleotides and the salts thereof
US3892730A (en) * 1971-06-23 1975-07-01 Upjohn Co 1{40 -({62 -hydroxyethyl)-1{40 -demethyl clindamycin 2-acylates
US3892729A (en) * 1971-06-23 1975-07-01 Upjohn Co 1{40 (Beta-hydroxyethyl)-1{40 -demethyl clindamycin 2-phosphates
US3915954A (en) * 1971-11-15 1975-10-28 Upjohn Co Derivatives of lincomycin and its analogs and process
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US4309533A (en) * 1980-05-19 1982-01-05 The Upjohn Company Lincomycin compounds
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US4464466A (en) * 1981-04-20 1984-08-07 The Upjohn Company Process of producing lincomycin nucleotides
US4568741A (en) * 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
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CA2328703C (en) * 1998-06-11 2007-10-30 Pharmacia & Upjohn Company Delavirdine tablet formulation
CN1425025A (zh) * 1999-12-15 2003-06-18 卡比斯特制药公司 作为抗菌剂的新颖的脂肽

Also Published As

Publication number Publication date
WO2003020736A1 (en) 2003-03-13
US20030073826A1 (en) 2003-04-17
ES2243763T3 (es) 2005-12-01
US20030073648A1 (en) 2003-04-17
US20050192236A1 (en) 2005-09-01
BR0212214A (pt) 2004-10-19
JP2005504785A (ja) 2005-02-17
TWI232865B (en) 2005-05-21
DE60204897T2 (de) 2006-05-11
MY134083A (en) 2007-11-30
ATE298758T1 (de) 2005-07-15
CA2458644A1 (en) 2003-03-13
EP1421093B1 (de) 2005-06-29
EP1421093A1 (de) 2004-05-26
US20030073647A1 (en) 2003-04-17
MXPA04001964A (es) 2004-06-07
AR037654A1 (es) 2004-12-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee