ES2570429T3 - Inhibidores de heteroaril quinasa de anillo condensado - Google Patents

Inhibidores de heteroaril quinasa de anillo condensado

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Publication number
ES2570429T3
ES2570429T3 ES09821313T ES09821313T ES2570429T3 ES 2570429 T3 ES2570429 T3 ES 2570429T3 ES 09821313 T ES09821313 T ES 09821313T ES 09821313 T ES09821313 T ES 09821313T ES 2570429 T3 ES2570429 T3 ES 2570429T3
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Spain
Prior art keywords
substituted
unsubstituted
alkyl
heteroaryl
aryl
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ES09821313T
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English (en)
Inventor
Arvin Dar
Kevan M Shokat
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University of California
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University of California
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto que tiene la fórmula:**Fórmula** en la que x es un número entero de 0 a 4; 1 y es un número entero de 0 a 5; el anillo A es arileno o heteroarileno; el anillo B es arilo o heteroarilo; Z1 es -N>= o -C(R22)>=; Z2 es -N>= o -C(R23)>=; R1 y R2 son independientemente hidrógeno, alquilo sustituido o sin sustituir o heteroalquilo sustituido o sin sustituir; R3 es independientemente alquilo sustituido o sin sustituir, -CN, -CF3, -S(O)nR6, -N(O)m, -NR7R8, -C(O)R9, -NR10- C(O)R11, -NR12-C(O)-OR13, -C(O)NR14R15, -NR16S(O)2R17, -S(O)2NR18R18', -OR19, halometilo, heteroalquilo sustituido o sin sustituir, cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, o heteroarilo sustituido o sin sustituir; R22 es independientemente alquilo sustituido o sin sustituir, -CN, -CF3, -S(O)nR6, -N(O)m, -NR7R8, -C(O)R9, -NR10- C(O)R11, -NR12-C(O)-OR13, -C(O)NR14R15, -NR16S(O)2R17, -S(O)2NR18R18', -OR19, halometilo, heteroalquilo sustituido o sin sustituir, cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, o heteroarilo sustituido o sin sustituir; R23 es independientemente alquilo sustituido o sin sustituir, -CN, -CF3, -S(O)nR6, -N(O)m, -NR7R8, -C(O)R9, -NR10- C(O)R11, -NR12-C(O)-OR13, -C(O)NR14R15, -NR16S(O)2R17, -S(O)2NR18R18', -OR19, halometilo, heteroalquilo sustituido o sin sustituir, cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, o heteroarilo sustituido o sin sustituir; R4 y R5 son independientemente halógeno, -CN, -CF3, -S(O)nR6, -N(O)m, -NR7R8, -C(O)R9, -NR10-C(O)R11, -NR12- C(O)-OR13, -C(O)NR14R15, -NR16S(O)2R17, -S(O)2NR18R18', -OR19, halometilo, alquilo sustituido o sin sustituir, heteroalquilo sustituido o sin sustituir, cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, o heteroarilo sustituido o sin sustituir; n es un número entero de 0 a 2; m es un número entero de 1 a 2; R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R18', R19 y R20 son independientemente hidrógeno, alquilo sustituido o sin sustituir, heteroalquilo sustituido o sin sustituir, cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, o heteroarilo sustituido o sin sustituir; L1 es un enlace, alquileno sustituido o sin sustituir o heteroalquileno sustituido o sin sustituir; L2 es -C(O) -, -S(O)-, o -S(O)2-; L3 es -N(R20)-, un enlace, alquileno sustituido o sin sustituir, o heteroalquileno sustituido o sin sustituir; y L4 es -NH-, un enlace o -CH2-; en la que el compuesto se selecciona de entre: (i) compuestos en los que L4-L2-L3 es -NH-C(O)-NH- y donde R3 es independientemente alquilo sin sustituir, -CN, - CF3, -S(O)nR6, -N(O)m, -NR7R8, -C(O)R9, -NR10-C(O)R11, -NR12-C(O)-OR13, -C(O)NR14R15, -NR16S(O)2R17, - S(O)2NR18R18', -OR19, halometilo, heteroalquilo sin sustituir, cicloalquilo sin sustituir, arilo sin sustituir, o heteroarilo sin sustituir; (ii) compuestos en los que L1 es alquileno sustituido o sin sustituir o heteroalquileno sustituido o sin sustituir; (iii) compuestos en los que R3 es alquilo C1-C10 o ciclopentilo; y (iv) compuestos de fórmula Ib en la que R3 es pirrolidina o tetrahidrofurano:
ES09821313T 2008-10-16 2009-10-16 Inhibidores de heteroaril quinasa de anillo condensado Active ES2570429T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10613708P 2008-10-16 2008-10-16
US10645308P 2008-10-17 2008-10-17
PCT/US2009/060985 WO2010045542A2 (en) 2008-10-16 2009-10-16 Fused ring heteroaryl kinase inhibitors

Publications (1)

Publication Number Publication Date
ES2570429T3 true ES2570429T3 (es) 2016-05-18

Family

ID=42107267

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09821313T Active ES2570429T3 (es) 2008-10-16 2009-10-16 Inhibidores de heteroaril quinasa de anillo condensado

Country Status (8)

Country Link
US (1) US8697709B2 (es)
EP (1) EP2358720B1 (es)
JP (2) JP5819195B2 (es)
AU (4) AU2009305669A1 (es)
CA (1) CA2740885C (es)
DK (1) DK2358720T3 (es)
ES (1) ES2570429T3 (es)
WO (1) WO2010045542A2 (es)

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