DE602004025504D1 - Bicyclische heterocyclische p-38-kinase-inhibitoren - Google Patents
Bicyclische heterocyclische p-38-kinase-inhibitorenInfo
- Publication number
- DE602004025504D1 DE602004025504D1 DE602004025504T DE602004025504T DE602004025504D1 DE 602004025504 D1 DE602004025504 D1 DE 602004025504D1 DE 602004025504 T DE602004025504 T DE 602004025504T DE 602004025504 T DE602004025504 T DE 602004025504T DE 602004025504 D1 DE602004025504 D1 DE 602004025504D1
- Authority
- DE
- Germany
- Prior art keywords
- kinase inhibitors
- bicyclic heterocyclic
- kinase
- disorders
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53252903P | 2003-12-23 | 2003-12-23 | |
US57511304P | 2004-05-28 | 2004-05-28 | |
PCT/US2004/043682 WO2005063766A2 (en) | 2003-12-23 | 2004-12-23 | Bicyclic heterocyclic p-38 kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004025504D1 true DE602004025504D1 (de) | 2010-03-25 |
Family
ID=34743022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004025504T Active DE602004025504D1 (de) | 2003-12-23 | 2004-12-23 | Bicyclische heterocyclische p-38-kinase-inhibitoren |
Country Status (14)
Country | Link |
---|---|
US (2) | US7569571B2 (de) |
EP (1) | EP1699800B1 (de) |
JP (1) | JP2007517052A (de) |
KR (1) | KR100899245B1 (de) |
AT (1) | ATE457313T1 (de) |
AU (1) | AU2004309420B2 (de) |
BR (1) | BRPI0418112A (de) |
CA (1) | CA2548326A1 (de) |
DE (1) | DE602004025504D1 (de) |
ES (1) | ES2339670T3 (de) |
PL (1) | PL1699800T3 (de) |
PT (1) | PT1699800E (de) |
RU (1) | RU2006126791A (de) |
WO (1) | WO2005063766A2 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004259662B2 (en) | 2003-06-26 | 2008-08-07 | Mereo Biopharma 1 Limited | 5-membered heterocycle-based p38 kinase inhibitors |
CA2532971A1 (en) | 2003-07-14 | 2005-01-27 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
EP1720877A4 (de) * | 2004-03-02 | 2009-11-04 | Neurogen Corp | Arylsubstituierte purinanaloga |
WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
RU2008110941A (ru) | 2005-08-25 | 2009-09-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | ИНГИБИТОРЫ КИНАЗЫ p38 МАР И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
JP2009506007A (ja) * | 2005-08-25 | 2009-02-12 | エフ.ホフマン−ラ ロシュ アーゲー | p38MAPキナーゼ阻害剤及びその使用方法 |
TWI403320B (zh) * | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制bcl蛋白和結合夥伴間之交互作用的化合物及方法 |
US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
WO2008127226A2 (en) | 2006-04-04 | 2008-10-23 | The Regents Of The University Of California | P13 kinase antagonists |
EP2091952A1 (de) | 2006-12-19 | 2009-08-26 | F. Hoffmann-Roche AG | Pyrazolo[3,4-d]pyrimidine als inhibitoren von p38-map-kinase |
AU2008248296B2 (en) | 2007-05-07 | 2011-12-01 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators, process for their preparation, and their pharmaceutical use |
EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
US8080546B2 (en) | 2007-10-26 | 2011-12-20 | Amgen Inc. | Pyrazolo-pyridinone derivatives and methods of use |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
KR101897881B1 (ko) | 2008-01-04 | 2018-09-12 | 인텔리카인, 엘엘씨 | 특정 화학 물질, 조성물 및 방법 |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
JP5547099B2 (ja) * | 2008-03-14 | 2014-07-09 | インテリカイン, エルエルシー | キナーゼ阻害剤および使用方法 |
WO2009117156A1 (en) | 2008-03-21 | 2009-09-24 | Amgen Inc. | Pyrazolo-pyrazinone compounds and methods of use thereof |
CN102124009B (zh) | 2008-07-08 | 2014-07-23 | 因特利凯公司 | 激酶抑制剂及其使用方法 |
US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
CA2760791C (en) | 2009-05-07 | 2017-06-20 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
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- 2004-12-23 BR BRPI0418112-3A patent/BRPI0418112A/pt not_active IP Right Cessation
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- 2004-12-23 EP EP04815697A patent/EP1699800B1/de not_active Not-in-force
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- 2004-12-23 AT AT04815697T patent/ATE457313T1/de not_active IP Right Cessation
- 2004-12-23 PL PL04815697T patent/PL1699800T3/pl unknown
- 2004-12-23 RU RU2006126791/04A patent/RU2006126791A/ru not_active Application Discontinuation
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KR100899245B1 (ko) | 2009-05-26 |
US20090264409A1 (en) | 2009-10-22 |
BRPI0418112A (pt) | 2007-04-17 |
JP2007517052A (ja) | 2007-06-28 |
KR20060103272A (ko) | 2006-09-28 |
US20070142405A1 (en) | 2007-06-21 |
AU2004309420B2 (en) | 2008-10-30 |
ATE457313T1 (de) | 2010-02-15 |
PL1699800T3 (pl) | 2010-07-30 |
EP1699800A2 (de) | 2006-09-13 |
EP1699800B1 (de) | 2010-02-10 |
CA2548326A1 (en) | 2005-07-14 |
WO2005063766A2 (en) | 2005-07-14 |
RU2006126791A (ru) | 2008-01-27 |
AU2004309420A1 (en) | 2005-07-14 |
ES2339670T3 (es) | 2010-05-24 |
WO2005063766A3 (en) | 2005-09-09 |
PT1699800E (pt) | 2010-04-12 |
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