MA55556A - Composés ciblant prmt5 - Google Patents

Composés ciblant prmt5

Info

Publication number
MA55556A
MA55556A MA055556A MA55556A MA55556A MA 55556 A MA55556 A MA 55556A MA 055556 A MA055556 A MA 055556A MA 55556 A MA55556 A MA 55556A MA 55556 A MA55556 A MA 55556A
Authority
MA
Morocco
Prior art keywords
compounds targeting
prmt5
targeting prmt5
compounds
targeting
Prior art date
Application number
MA055556A
Other languages
English (en)
Inventor
Leonid Beigelman
Yannick Debing
Jerome Deval
David Mcgowan
Pierre Jean-Marie Bernard Raboisson
Koen Vandyck
Original Assignee
Aligos Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aligos Therapeutics Inc filed Critical Aligos Therapeutics Inc
Publication of MA55556A publication Critical patent/MA55556A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA055556A 2019-04-02 2020-03-31 Composés ciblant prmt5 MA55556A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962828282P 2019-04-02 2019-04-02
US201962877411P 2019-07-23 2019-07-23
US201962946649P 2019-12-11 2019-12-11

Publications (1)

Publication Number Publication Date
MA55556A true MA55556A (fr) 2022-02-09

Family

ID=72661994

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055556A MA55556A (fr) 2019-04-02 2020-03-31 Composés ciblant prmt5

Country Status (14)

Country Link
US (2) US11198699B2 (fr)
EP (1) EP3947388A4 (fr)
JP (1) JP2022522534A (fr)
KR (1) KR20210145787A (fr)
CN (1) CN114072407A (fr)
AU (1) AU2020256166A1 (fr)
BR (1) BR112021019465A8 (fr)
CA (1) CA3134613A1 (fr)
IL (1) IL286849A (fr)
MA (1) MA55556A (fr)
MX (1) MX2021011606A (fr)
SG (1) SG11202110742TA (fr)
TW (1) TW202102509A (fr)
WO (1) WO2020205867A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11077101B1 (en) 2018-07-18 2021-08-03 Tango Therapeutics, Inc. Compounds and methods of use
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2020033282A1 (fr) * 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
SG11202110742TA (en) * 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5
AU2020394887A1 (en) 2019-12-03 2022-06-16 Lupin Limited Substituted nucleoside analogs as PRMT5 inhibitors
US20220112194A1 (en) * 2020-04-01 2022-04-14 Aligos Therapeutics, Inc. Compounds targeting prmt5
IL300147A (en) 2020-07-31 2023-03-01 Tango Therapeutics Inc History Piperidin-1-yl-N-pyridin-3-yl-2-oxaacetamide is useful for the treatment of MTAP-deficient and/or MTA-accumulating cancer
CN117157297A (zh) * 2021-07-20 2023-12-01 上海齐鲁制药研究中心有限公司 Prmt5抑制剂
CN116655638B (zh) * 2022-05-12 2024-01-26 上海齐鲁制药研究中心有限公司 氘代prmt5抑制剂

Family Cites Families (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2580091B2 (ja) 1990-01-11 1997-02-12 アイシス・ファーマシューティカルス・インコーポレーテッド Ｒｎａ活性および遺伝子発現を検出および変調するための組成物および方法
DE69120699T2 (de) 1990-03-08 1997-01-09 Fujisawa Pharmaceutical Co N-Monosubstituierte Cyclopentenylamine, ein Verfahren zu ihrer Herstellung, und ihre Verwendung als Medikament
CA2133325A1 (fr) 1992-04-21 1993-10-28 I. Charles Pathirana Composes agonistes et antagonistes non steroidiens du recepteur de la progesterone
GB9307694D0 (en) 1993-04-14 1993-06-02 Smithkine Beecham Corp Novel compounds
GB2291872A (en) 1994-08-02 1996-02-07 Zeneca Ltd Alkyl cyclopentane-carboxylate fungicides
US5681940A (en) 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
US5900415A (en) 1994-11-07 1999-05-04 Pfizer Inc. Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
AU692977B2 (en) 1994-11-07 1998-06-18 Pfizer Inc. Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
DE19501482A1 (de) 1995-01-19 1996-07-25 Bayer Ag 2,9-disubstituierte Purin-6-one
US5514505A (en) 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
CA2260982A1 (fr) 1996-07-23 1998-01-29 Neurogen Corporation Derives benzylamine substitues et nouvelle classe de ligands specifiques des neuropeptides y1
JP2000515527A (ja) 1996-07-23 2000-11-21 ニューロジェン・コーポレーション 特定のアミド―およびアミノ―置換ベンジルアミン誘導体；新種の神経ペプチドｙ１特異的リガンド
CA2261031A1 (fr) 1996-07-23 1998-01-29 Charles A. Blum Derives benzylamine substitues et nouvelle classe de ligands specifiques des neuropeptides y1
JP2001524936A (ja) 1996-10-16 2001-12-04 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド プリンｌ―ヌクレオシド類およびその用途
AU2307899A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
WO1999032479A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Derives de phtalamidepiperidine, de phtalamidepyrrolidine, et de phtalamide-azepine, leur preparation, et leur utilisation comme agonistes(antagonistes) des recepteurs muscariniques
AU2206699A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
WO1999032481A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Agents muscariniques et leur utilisation pour traiter le glaucome, la myopie, et d'autres dysfonctionnements
AU2206599A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Oximino-piperidine, -pyrrolidine and -azepine derivatives, their preparation andtheir use as muscarinic receptor (ant-)agonists
WO1999032443A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Agents muscariniques et leur utilisation pour traiter le glaucome, la myopie, et d'autres dysfonctionnements
CA2329660A1 (fr) 1998-04-23 1999-10-28 Abbott Laboratories Inhibiteurs de neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
CA2332528A1 (fr) 1998-05-21 1999-11-25 Shionogi & Co., Ltd. Inhibiteur spla2 pyrrolo[1,2-b] pyridazine
US6268372B1 (en) 1998-09-11 2001-07-31 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
MXPA02001340A (es) 1999-08-05 2004-07-16 Prescient Neuropharma Inc Compuestos novedosos 1,4-benzodiazepina y derivados de los mismos.
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
CA2381297A1 (fr) 1999-08-27 2001-04-19 Esmir Gunic Analogues nucleosidiques de pyrrolo¬2,3-d|pyrimidine
US6831069B2 (en) * 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
DE10142100A1 (de) 2001-08-30 2003-04-03 Epcos Ag Elektrolytlösung für Kondensatoren und ein Elektrolytkondensator mit der Elektrolytlösung sowie dessen Verwendung
WO2003039523A2 (fr) 2001-11-05 2003-05-15 Exiqon A/S Oligonucleotides modifies a l'aide de nouveaux analogues d'arn-l-alpha
EP1485395A4 (fr) 2002-02-28 2011-04-13 Biota Scient Management Mimetiques nucleotidiques et leurs promedicaments
NZ535763A (en) 2002-04-18 2007-06-29 Schering Corp (1-4-piperidinyl) benzimidazole derivatives useful as histamine H3 antagonists
EP1494671B1 (fr) 2002-04-18 2011-10-19 Schering Corporation 1-(4-piperidinyl)benzimidazolones utilises en tant qu'antagonistes du recepteur h3 de l'histamine
ATE503764T1 (de) 2002-05-20 2011-04-15 Bristol Myers Squibb Co Inhibitoren des hepatitis-c-virus
AU2003259735A1 (en) 2002-08-08 2004-02-25 Sirna Therapeutics, Inc. Small-mer compositions and methods of use
EP1551845A1 (fr) 2002-10-11 2005-07-13 Ligand Pharmaceuticals, Inc. Derives de 5-cycloalcenyle 5 i h /i -chromeno 3,4-f]quinoline servant de composes modulateurs selectifs du recepteur de la progesterone
WO2004050024A2 (fr) 2002-11-27 2004-06-17 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
WO2004081643A1 (fr) 2002-12-20 2004-09-23 Kaiser Aerospace & Electronics Corp. Reseau de lentilles a conversion de polarisation
BRPI0409198A (pt) 2003-04-04 2006-05-02 Novartis Ag derivados quinolin-2-ona para o tratamento de doenças de vias aéreas
JP4661029B2 (ja) 2003-05-22 2011-03-30 東ソー株式会社 光学活性マレイミド誘導体、光学活性ポリマレイミド誘導体、その製造方法、その光学活性ポリマレイミド誘導体からなる分離剤及びそれを用いた光学活性化合物の分離方法
WO2004106356A1 (fr) 2003-05-27 2004-12-09 Syddansk Universitet Derives de nucleotides fonctionnalises
DE602004029904D1 (de) 2003-08-27 2010-12-16 Biota Scient Management Neue tricyclische nukleoside oder nukleotide als therapeutische mittel
WO2005034878A2 (fr) 2003-10-08 2005-04-21 President And Fellows Of Harvard College Analogues de pyrovalerone et utilisations therapeutiques
US20070078120A1 (en) 2003-10-21 2007-04-05 Hitoshi Ban Novel piperidine derivative
AP2439A (en) 2003-12-18 2012-08-31 Incyte Corp 3-Cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
CA2548326A1 (fr) 2003-12-23 2005-07-14 Novartis Ag Inhibiteurs heterocycliques bicycliques des kinases p-38
JPWO2005097738A1 (ja) 2004-04-06 2008-02-28 大日本住友製薬株式会社 新規スルホンアミド誘導体
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
EP1768954A4 (fr) 2004-06-24 2008-05-28 Incyte Corp 2-methylpropanamides et leur utilisation en tant que pharmaceutiques
EP1616874A1 (fr) 2004-07-14 2006-01-18 Universiteit Gent Composés mono- et bicycliques à activité thérapeutique et compositions pharmaceutiques les comprenant
JP2006124326A (ja) 2004-10-28 2006-05-18 Sumitomo Chemical Co Ltd クロピドグレルの製造方法
WO2006081264A1 (fr) 2005-01-25 2006-08-03 Glaxo Group Limited Agents antibacteriens
PT1848718E (pt) 2005-02-04 2012-10-11 Millennium Pharm Inc Inibidores de enzimas de activação e1
JP2006241090A (ja) 2005-03-04 2006-09-14 Tosoh Corp 光学活性カルボン酸類の分離方法
US8802840B2 (en) 2005-03-08 2014-08-12 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
EP1866298A2 (fr) 2005-03-31 2007-12-19 Takeda San Diego, Inc. Inhibiteurs de l'hydroxysteroide deshydrogenase
WO2007002057A1 (fr) 2005-06-20 2007-01-04 Schering Corporation Pipéridines substituées liées à un atome de carbone et leurs dérivés utiles en tant qu’antagonistes de l'histamine h3
US7635705B2 (en) 2005-06-20 2009-12-22 Schering Corporation Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists
DE102005059891A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag 3'-Alkoxy-spirocyclopentyl substituierte Tetram- und Tetronsäuren
DE102005059892A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag Alkylthio-spirocyclische Tetramsäuren
US20090005411A1 (en) 2005-12-20 2009-01-01 Novartic Ag Combinations of Organic Compounds
JP2009521445A (ja) 2005-12-21 2009-06-04 シェーリング コーポレイション Ｈ３アンタゴニスト／逆アゴニストと食欲抑制剤との組み合わせ
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
CA2823724A1 (fr) 2006-04-24 2007-11-08 Allergan, Inc. Cannabidiols anormaux utiles comme agents destines a faire baisser la pression intraoculaire
CN101516850B (zh) 2006-08-08 2014-05-07 米伦纽姆医药公司 适用作e1活化酶抑制剂的杂芳基化合物
BRPI0719543A2 (pt) 2006-11-28 2014-02-25 Novartis Ag Combinação de inibidores de iap e inibidores de flt3
DE102006056740A1 (de) 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
CN101195586A (zh) 2006-12-05 2008-06-11 中国科学院上海药物研究所 一类具有取代环戊烷结构的化合物、制备方法及其医学用途
US20130012485A1 (en) 2006-12-22 2013-01-10 Baeschlin Daniel Kaspar Organic compounds
US8133895B2 (en) 2007-05-10 2012-03-13 Janssen Pharmaceutica N.V. Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
CN103483342B (zh) 2007-08-02 2016-08-31 米伦纽姆医药公司 合成e1活化酶抑制剂的方法
US8598165B2 (en) 2007-11-26 2013-12-03 University Of Kansas Morpholines as selective inhibitors of cytochrome P450 2A13
WO2009124103A2 (fr) 2008-04-02 2009-10-08 Schering Corporation Thérapies de combinaison comprenant des antagonistes de récepteur 1 activé par protéase (par1) associés à des antagonistes récepteur 4 activé par protéase (par4)
WO2009129094A2 (fr) 2008-04-15 2009-10-22 Mallinckrodt Inc. Compositions contenant des composés antiviraux et leurs procédés d’utilisation
WO2009132453A1 (fr) 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Dérivés de cyclylamine utilisés comme agents bloquant le canal calcique
WO2010030858A1 (fr) 2008-09-15 2010-03-18 Enanta Pharmaceuticals, Inc. Dérivés de nucléosides 4'-allène-substitués
KR20110079847A (ko) 2008-10-30 2011-07-08 온코세라피 사이언스 가부시키가이샤 7-하이드록시-벤조이미다졸-4-일-메타논 유도체 및 이를 함유하는 ｐｂｋ 저해제
US8722082B2 (en) 2008-11-10 2014-05-13 Tekmira Pharmaceuticals Corporation Lipids and compositions for the delivery of therapeutics
AU2009318719A1 (en) 2008-11-20 2011-06-30 Oncotherapy Science, Inc. Glycogen synthase kinase-3 beta inhibitors containing 7-hydroxy-benzoimidazole-4-yl-methanone derivatives
KR101774429B1 (ko) 2009-02-06 2017-09-04 코크리스탈 파마, 아이엔씨. 암 및 바이러스 감염 치료용 퓨린 뉴클레오시드 모노포스페이트 프로드럭
WO2010108140A1 (fr) 2009-03-20 2010-09-23 Alios Biopharma, Inc. Nucleoside substitue et analogues nucleotidiques
EP2264169A1 (fr) 2009-06-15 2010-12-22 Qiagen GmbH SiNA modifié
US20100331397A1 (en) 2009-06-24 2010-12-30 Alios Biopharma, Inc. 2-5a analogs and their methods of use
WO2011005860A2 (fr) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. Mimétiques de 5' phosphate
KR101049260B1 (ko) 2009-07-23 2011-07-13 주식회사 엘지화학 새로운 포스트 메탈로센형 전이금속 화합물
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
TW201118099A (en) 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
KR20120078715A (ko) 2009-09-10 2012-07-10 노파르티스 아게 암의 치료를 위한 ｂｃｌ-2군 단백질의 억제제로서의 술폰아미드
WO2011057204A2 (fr) 2009-11-06 2011-05-12 The Johns Hopkins University Toxicité neuronale médiée par lrrk2
WO2011061590A1 (fr) 2009-11-17 2011-05-26 Hetero Research Foundation Nouveaux dérivés carboxamides comme inhibiteurs du vih
US20130172553A1 (en) 2009-11-25 2013-07-04 Cpsi Stockholder Trust Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof
DK2513053T3 (en) 2009-12-18 2018-01-08 Ogeda Sa PYRROLIDINCARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS OF USE IN TREATMENT OF METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN CONNECTED RECEPTOR 43 (GPR43)
US9433621B2 (en) 2010-02-18 2016-09-06 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US9725479B2 (en) 2010-04-22 2017-08-08 Ionis Pharmaceuticals, Inc. 5′-end derivatives
US8735312B2 (en) 2010-04-23 2014-05-27 Lg Chem, Ltd. Catalyst composition and process for preparing olefin polymer using the same
JP2013147430A (ja) 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
KR20110123657A (ko) 2010-05-07 2011-11-15 에스케이케미칼주식회사 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물
CA2801001A1 (fr) 2010-06-01 2011-12-08 Biotheryx, Inc. Derives d'hydroxypyridone, compositions pharmaceutiques realisees a partir de ces derives, et utilisations therapeutiques correspondants pour traiter des maladies proliferatives
WO2012025857A1 (fr) 2010-08-23 2012-03-01 Hetero Research Foundation Dérivés de cycloalkyl méthoxybenzyl phényl pyrane en tant qu'inhibiteurs du cotransporteur de glucose sodium-dépendant (sglt2)
AU2011297888A1 (en) 2010-09-03 2013-04-11 Grünenthal GmbH Substituted tetrahydropyrrolopyrazine derivatives
CN105061534A (zh) 2010-09-22 2015-11-18 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
US20120070411A1 (en) 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
AR083199A1 (es) 2010-09-29 2013-02-06 Intervet Internationale B V Compuestos de n-heteroarilo con unidad de puente ciclico
JP5931905B2 (ja) 2010-12-03 2016-06-08 エピザイム，インコーポレイティド 置換プリン及び７‐デアザプリン化合物
WO2012114223A1 (fr) 2011-02-25 2012-08-30 Pfizer Limited Méthode de traitement de la fibrose hépatique
EP2508511A1 (fr) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques
MX2014000797A (es) 2011-07-19 2014-07-09 Univ Idaho Sonda y metodo para direccionar acidos nucleicos.
CN102924457A (zh) 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
AU2012311184A1 (en) 2011-09-22 2014-03-06 Pfizer Inc. Pyrrolopyrimidine and purine derivatives
CN103102345B (zh) 2011-11-14 2015-06-03 广东东阳光药业有限公司 氨基喹唑啉类衍生物及其盐和使用方法
WO2013096939A1 (fr) 2011-12-23 2013-06-27 Sri International Composés de liaison sélective
WO2013120040A1 (fr) 2012-02-10 2013-08-15 Children's Medical Center Corporation Inhibition d'une voie ciblée pour améliorer la structure, le fonctionnement et l'activité musculaires dans la dystrophie musculaire
US20150057243A1 (en) 2012-04-02 2015-02-26 Northern University Compositions and Methods for the Inhibition of Methyltransferases
WO2013188881A1 (fr) 2012-06-15 2013-12-19 President And Fellows Of Harvard College Composés, compositions et méthodes de traitement ou de prévention de troubles neurodégénératifs
AR092348A1 (es) 2012-07-11 2015-04-15 Hoffmann La Roche DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc
WO2014026198A1 (fr) 2012-08-10 2014-02-13 Epizyme, Inc. Inhibiteurs de protéine méthyltransférase de dot1l et leurs procédés d'utilisation
SG11201408791TA (en) 2012-08-24 2015-01-29 Sunshine Lake Pharma Co Ltd Dihydropyrimidine compounds and their application in pharmaceuticals
CA2889717A1 (fr) 2012-10-29 2014-05-08 Cocrystal Pharma, Inc. Nucleotides pyrimidines et leurs promedicaments monophosphates pour le traitement d'infections virales et du cancer
EP2928866A1 (fr) 2012-12-10 2015-10-14 F. Hoffmann-La Roche AG Utilisation de dérivés de sulfonamide de benzyle comme modulateurs de rorc
CA2903312A1 (fr) 2013-03-14 2014-09-25 Epizyme, Inc. Polytherapie pour traiter un cancer
EP2968233A4 (fr) 2013-03-14 2016-08-03 Chdi Foundation Inc Inhibiteurs d'histone désacétylase, et compositions et méthodes d'utilisation associées
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
JP6473133B2 (ja) 2013-03-15 2019-02-20 アラクセス ファーマ エルエルシー Ｋｒａｓｇ１２ｃの共有結合性阻害剤
US9688627B2 (en) 2013-03-15 2017-06-27 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
WO2015077360A2 (fr) 2013-11-20 2015-05-28 Idenix Pharmaceuticals, Inc. Analogues nucléosidiques renfermant un cyclopentane ou un cyclopentène pour le traitement de l'hépatite c
TWI608080B (zh) 2014-01-29 2017-12-11 達興材料股份有限公司 液晶化合物、液晶組成物以及液晶顯示元件
CN105979951B (zh) * 2014-02-06 2020-12-25 里博科学有限责任公司 作为流感rna复制的抑制剂的4’-二氟甲基取代的核苷衍生物
RU2016149804A (ru) 2014-05-23 2018-06-26 Ф. Хоффманн-Ля Рош Аг Производные бензолсульфонамида и их применение в качестве модуляторов орфанного рецептора y, связанного с ретиноевой кислотой
CN104059674B (zh) 2014-06-06 2016-01-20 北京八亿时空液晶科技股份有限公司 一种含有二氟甲氧基桥键的液晶化合物及其应用
CN104087312B (zh) 2014-06-17 2016-07-06 北京八亿时空液晶科技股份有限公司 一种液晶组合物及其应用
CA2952959C (fr) * 2014-06-24 2023-03-07 Alios Biopharma, Inc. Utilisation de nucleosides et de nucleotides pour traiter une infection de filovirus
AR101214A1 (es) 2014-07-22 2016-11-30 Bayer Cropscience Ag Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas
JP6571756B2 (ja) 2014-07-31 2019-09-04 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 神経変性疾患に適応可能なインドリジン誘導体
EP3180344B1 (fr) 2014-08-12 2019-09-18 Pfizer Inc Dérivés de pyrrolo[2,3-d]pyrimidine utiles pour inhiber la janus kinase
AU2015318593A1 (en) 2014-09-17 2017-02-23 Epizyme, Inc. Combination therapy for treating cancer
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049565A1 (fr) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions et procédés pour inhiber la ras
EP3197870B1 (fr) 2014-09-25 2020-08-19 Araxes Pharma LLC Inhibiteurs de protéines mutantes kras g12c
BR112017006264A2 (pt) * 2014-09-26 2017-12-12 Riboscience Llc derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório
EP3212201B1 (fr) 2014-10-28 2022-10-19 BCI Pharma Inhibiteurs de la kinase nucléoside
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
US10767112B2 (en) 2015-01-15 2020-09-08 The Trustees Of The Columbia University In The City Of New York Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control
WO2016145142A1 (fr) 2015-03-10 2016-09-15 Emory University Compositions thérapeutiques renfermant des nucléotides et des nucléosides et utilisations associées
FR3034767A1 (fr) 2015-04-07 2016-10-14 Centre Nat Rech Scient Reduction des fonctions carbonyles de glucides et derives de glucides en milieu aqueux par le dithionite de sodium
JP6928385B2 (ja) 2015-08-10 2021-09-01 アルジオン， インコーポレイテッド 神経変性疾患を治療および予防するための組成物および方法
TW202321249A (zh) 2015-08-26 2023-06-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６－６雙環芳香環取代之核苷類似物
US9926277B2 (en) 2015-10-02 2018-03-27 Biotheryx, Inc. Pyridone compounds, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases
US11433047B2 (en) 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
WO2017066781A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm à liaison phosphate modifié
WO2017066789A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm avec sucre modifié
WO2017066791A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm à substitution sucre
US20190225644A1 (en) 2015-10-16 2019-07-25 Modernatx, Inc. Mrna cap analogs and methods of mrna capping
US11866754B2 (en) 2015-10-16 2024-01-09 Modernatx, Inc. Trinucleotide mRNA cap analogs
WO2017066782A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffes d'arnm hydrophobes
WO2017099969A1 (fr) 2015-12-10 2017-06-15 Merck Sharp & Dohme Corp. Modulateurs allostériques positifs du récepteur muscarinique m1 tétrahydroquinoxaline
WO2017117443A1 (fr) 2015-12-31 2017-07-06 Braskem America, Inc. Système catalytique sans phtalate et son utilisation dans la polymérisation d'oléfines
AU2017230658B2 (en) 2016-03-10 2021-03-04 Janssen Pharmaceutica Nv Substituted nucleoside analogues for use as PRMT5 inhibitors
CA2969295A1 (fr) 2016-06-06 2017-12-06 Pfizer Inc. Derives de carbonucleosides substitues et leur utilisation comme inhibiteur de prmt5
CN109071392B (zh) 2016-06-08 2020-10-02 四川海思科制药有限公司 苯环衍生物及其制备方法和在医药上的应用
WO2018022761A1 (fr) 2016-07-27 2018-02-01 Blueprint Medicines Corporation Cyclopentane-amides substitués pour le traitement des troubles liés au ret
CN107674029A (zh) 2016-08-02 2018-02-09 上海迪诺医药科技有限公司 多环化合物、其药物组合物及应用
CN107674013B (zh) 2016-08-02 2022-05-24 上海迪诺医药科技有限公司 多环化合物、其制备方法、药物组合物及应用
CN107793409B (zh) 2016-09-05 2022-09-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
WO2018065365A1 (fr) * 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Nouveaux analogues de carbanucléoside substitués par un système cyclique, monocyclique et bicyclique destinés à être utilisés en tant qu'inhibiteurs de prmt5
WO2018065353A1 (fr) 2016-10-03 2018-04-12 Umicore Ag & Co. Kg Article catalyseur et procédé de réduction d'ammoniac et d'oxydes d'azote
JP2018070512A (ja) 2016-10-31 2018-05-10 住友化学株式会社 有害節足動物防除組成物
WO2018081863A1 (fr) 2016-11-04 2018-05-11 University Of Wollongong Dérivés à substitution en position 6 de l'hexaméthylène amiloride en tant qu'inhibiteurs de upa et leurs utilisations
WO2018085818A1 (fr) * 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
CN108276463A (zh) 2017-01-06 2018-07-13 米文君 一类新的化合物及其用途
US11220524B2 (en) 2017-02-20 2022-01-11 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
WO2018152501A1 (fr) 2017-02-20 2018-08-23 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
TN2019000212A1 (en) 2017-02-27 2021-01-07 Janssen Pharmaceutica Nv Use of biomarkers in identifying cancer patients that will be responsive to treatment with a prmt5 inhibitor
WO2018160824A1 (fr) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
CN110461838B (zh) 2017-03-07 2022-05-06 豪夫迈·罗氏有限公司 噁二唑瞬时受体电位通道抑制剂
WO2018213258A1 (fr) 2017-05-15 2018-11-22 Millennium Pharmaceuticals, Inc. Traitement de tumeurs déficientes en merlin à l'aide d'inhibiteurs de nae
CN110997653B (zh) 2017-06-09 2023-06-06 百时美施贵宝公司 芳基杂环哌啶酮甲酰肽2受体和甲酰肽1受体激动剂
US20200369667A1 (en) 2017-12-05 2020-11-26 Angex Pharmaceutical, Inc. Heterocyclic compounds as prmt5 inhibitors
RS63623B1 (sr) * 2017-12-13 2022-10-31 Lupin Ltd Supstituisana biciklična heterociklična jedinjenja kao inhibitori prmt5
KR20190076339A (ko) 2017-12-22 2019-07-02 한미약품 주식회사 신규한 2,6-나프티리딘 2-옥시드 유도체 화합물 및 이의 용도
WO2019177873A1 (fr) 2018-03-13 2019-09-19 Merck Sharp & Dohme Corp. Inhibiteurs d'arginase et procédés d'utilisation
CN110386954B (zh) 2018-04-16 2020-08-21 中国科学院化学研究所 含不对称稠环吡啶亚胺基配合物及其制备方法与应用
EP3787635A4 (fr) 2018-04-30 2022-03-02 Oric Pharmaceuticals, Inc. Inhibiteurs de cd73
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
US20210309687A1 (en) 2018-08-07 2021-10-07 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033282A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
CA3108388A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
JP7427658B2 (ja) 2018-09-18 2024-02-05 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロペンチル酸
SG11202110742TA (en) * 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5
CN110423265A (zh) 2019-04-03 2019-11-08 中国药科大学 一种环肽类trf2抑制剂的制备方法和用途

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