MA55556A - Composés ciblant prmt5 - Google Patents

Composés ciblant prmt5

Info

Publication number
MA55556A
MA55556A MA055556A MA55556A MA55556A MA 55556 A MA55556 A MA 55556A MA 055556 A MA055556 A MA 055556A MA 55556 A MA55556 A MA 55556A MA 55556 A MA55556 A MA 55556A
Authority
MA
Morocco
Prior art keywords
compounds targeting
prmt5
targeting prmt5
compounds
targeting
Prior art date
Application number
MA055556A
Other languages
English (en)
Inventor
Leonid Beigelman
Yannick Debing
Jerome Deval
David Mcgowan
Pierre Jean-Marie Bernard Raboisson
Koen Vandyck
Original Assignee
Aligos Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aligos Therapeutics Inc filed Critical Aligos Therapeutics Inc
Publication of MA55556A publication Critical patent/MA55556A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA055556A 2019-04-02 2020-03-31 Composés ciblant prmt5 MA55556A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962828282P 2019-04-02 2019-04-02
US201962877411P 2019-07-23 2019-07-23
US201962946649P 2019-12-11 2019-12-11

Publications (1)

Publication Number Publication Date
MA55556A true MA55556A (fr) 2022-02-09

Family

ID=72661994

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055556A MA55556A (fr) 2019-04-02 2020-03-31 Composés ciblant prmt5

Country Status (14)

Country Link
US (2) US11198699B2 (fr)
EP (1) EP3947388A4 (fr)
JP (1) JP2022522534A (fr)
KR (1) KR20210145787A (fr)
CN (1) CN114072407A (fr)
AU (1) AU2020256166A1 (fr)
BR (1) BR112021019465A8 (fr)
CA (1) CA3134613A1 (fr)
IL (1) IL286849A (fr)
MA (1) MA55556A (fr)
MX (1) MX2021011606A (fr)
SG (1) SG11202110742TA (fr)
TW (1) TW202102509A (fr)
WO (1) WO2020205867A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11077101B1 (en) 2018-07-18 2021-08-03 Tango Therapeutics, Inc. Compounds and methods of use
EP3833668A4 (fr) * 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
AU2020256166A1 (en) * 2019-04-02 2021-10-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
MX2022006735A (es) 2019-12-03 2022-07-21 Lupin Ltd Análogos de nucleósidos sustituidos como inhibidores de la prmt5.
US20220112194A1 (en) * 2020-04-01 2022-04-14 Aligos Therapeutics, Inc. Compounds targeting prmt5
EP4188920A1 (fr) 2020-07-31 2023-06-07 Tango Therapeutics, Inc. Dérivés de pipéridin-1-yl-n-pyrydine-3-yl-2-oxo-acétamide utiles pour le traitement de cancers déficients en mtap et/ou accumulant mta
WO2023001133A1 (fr) * 2021-07-20 2023-01-26 上海齐鲁制药研究中心有限公司 Inhibiteur de prmt5
CN116655638B (zh) * 2022-05-12 2024-01-26 上海齐鲁制药研究中心有限公司 氘代prmt5抑制剂

Family Cites Families (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU651569B2 (en) 1990-01-11 1994-07-28 Isis Pharmaceuticals, Inc. Compositions and methods for detecting and modulating RNA activity and gene expression
EP0445749B1 (fr) 1990-03-08 1996-07-10 Fujisawa Pharmaceutical Co., Ltd. Cyclopentènylamines N-monosubstituées, procédé pour leur préparation et leur emploi comme médicament
MX9302312A (es) 1992-04-21 1994-06-30 Ligand Pharm Inc Compuestos agonistas y antagonistas receptores de la progesterona, no esteroides y composiciones farmaceuticas que los contienen.
GB9307694D0 (en) 1993-04-14 1993-06-02 Smithkine Beecham Corp Novel compounds
GB2291872A (en) 1994-08-02 1996-02-07 Zeneca Ltd Alkyl cyclopentane-carboxylate fungicides
US5681940A (en) 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
BR9509610A (pt) 1994-11-07 1997-10-28 Pfizer Ligandos específicos de neuropeptideo Y1
US5900415A (en) 1994-11-07 1999-05-04 Pfizer Inc. Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands
DE19501482A1 (de) 1995-01-19 1996-07-25 Bayer Ag 2,9-disubstituierte Purin-6-one
US5514505A (en) 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
WO1998003493A1 (fr) 1996-07-23 1998-01-29 Neurogen Corporation Derives benzylamine substitues et nouvelle classe de ligands specifiques des neuropeptides y1
JP2000515527A (ja) 1996-07-23 2000-11-21 ニューロジェン・コーポレーション 特定のアミド―およびアミノ―置換ベンジルアミン誘導体；新種の神経ペプチドｙ１特異的リガンド
EP0915859B1 (fr) 1996-07-23 2003-01-02 Neurogen Corporation Derives benzylamine substitues et nouvelle classe de ligands specifiques des neuropeptides y1
KR100412480B1 (ko) 1996-10-16 2003-12-31 아이씨엔 파마슈티컬스, 인코포레이티드 푸린 ｌ-누클레오시드, 이의 유사체 및 이들의 용도
AU2206499A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia, and various other conditions
WO1999032486A1 (fr) 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Agents muscariniques et leur utilisation pour traiter le glaucome, la myopie, et d'autres dysfonctionnements
AU2206599A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Oximino-piperidine, -pyrrolidine and -azepine derivatives, their preparation andtheir use as muscarinic receptor (ant-)agonists
AU2095099A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparationand their use as muscarinic receptor (ant-)agonists
AU2307999A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
AU2206699A (en) 1997-12-23 1999-07-12 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
EP1087938A1 (fr) 1998-04-23 2001-04-04 Abbott Laboratories Inhibiteurs de neuraminidases
CA2332528A1 (fr) 1998-05-21 1999-11-25 Shionogi & Co., Ltd. Inhibiteur spla2 pyrrolo[1,2-b] pyridazine
US6268372B1 (en) 1998-09-11 2001-07-31 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
AU6420700A (en) 1999-08-05 2001-03-05 Prescient Neuropharma Inc. Novel 1,4-benzodiazepine compounds and derivatives thereof
WO2001014378A1 (fr) 1999-08-23 2001-03-01 Shionogi & Co., Ltd. DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2?
PL354094A1 (en) 1999-08-27 2003-12-29 Icn Pharmaceuticals, Inc.Icn Pharmaceuticals, Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
US6831069B2 (en) * 1999-08-27 2004-12-14 Ribapharm Inc. Pyrrolo[2,3-d]pyrimidine nucleoside analogs
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
DE10142100A1 (de) 2001-08-30 2003-04-03 Epcos Ag Elektrolytlösung für Kondensatoren und ein Elektrolytkondensator mit der Elektrolytlösung sowie dessen Verwendung
AU2002351077A1 (en) 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
RU2004128943A (ru) 2002-02-28 2005-04-20 Байота, Инк. (Us) Средства, имитирующие нуклеотиды, и их пролекарственные формы
AR040405A1 (es) 2002-04-18 2005-04-06 Schering Corp Derivados de bencimidazol utiles como antagonistas de histamina h3
AU2003223631B2 (en) 2002-04-18 2006-07-20 Schering Corporation 1-(4-Piperidinyl) benzimidazolones as histamine H3 antagonists
PL215228B1 (pl) 2002-05-20 2013-11-29 Bristol Myers Squibb Co Zwiazki tripeptydowe, ich zastosowanie i kompozycja farmaceutyczna je zawierajaca oraz jej zastosowanie
AU2003259735A1 (en) 2002-08-08 2004-02-25 Sirna Therapeutics, Inc. Small-mer compositions and methods of use
EP1551845A1 (fr) 2002-10-11 2005-07-13 Ligand Pharmaceuticals, Inc. Derives de 5-cycloalcenyle 5 i h /i -chromeno 3,4-f]quinoline servant de composes modulateurs selectifs du recepteur de la progesterone
BRPI0316732B8 (pt) 2002-11-27 2021-05-25 Incyte Corp composto derivado de 3-aminopirrolidina e sua composição farmacêutica
WO2004081643A1 (fr) 2002-12-20 2004-09-23 Kaiser Aerospace & Electronics Corp. Reseau de lentilles a conversion de polarisation
AU2004226824B2 (en) 2003-04-04 2008-05-01 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
JP4661029B2 (ja) 2003-05-22 2011-03-30 東ソー株式会社 光学活性マレイミド誘導体、光学活性ポリマレイミド誘導体、その製造方法、その光学活性ポリマレイミド誘導体からなる分離剤及びそれを用いた光学活性化合物の分離方法
WO2004106356A1 (fr) 2003-05-27 2004-12-09 Syddansk Universitet Derives de nucleotides fonctionnalises
CA2537114C (fr) 2003-08-27 2012-10-02 Biota, Inc. Nucleotides ou nucleosides tricycliques en tant qu'agents therapeutiques
AU2004280256A1 (en) 2003-10-08 2005-04-21 Organix, Inc. Pyrovalerone analogs and therapeutic uses thereof
WO2005037269A1 (fr) 2003-10-21 2005-04-28 Dainippon Sumitomo Pharma Co., Ltd. Nouveau derive de piperidine
US7576089B2 (en) 2003-12-18 2009-08-18 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
WO2005063766A2 (fr) 2003-12-23 2005-07-14 Novartis Ag Inhibiteurs heterocycliques bicycliques des kinases p-38
JPWO2005097738A1 (ja) 2004-04-06 2008-02-28 大日本住友製薬株式会社 新規スルホンアミド誘導体
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
JP2008504280A (ja) 2004-06-24 2008-02-14 インサイト・コーポレイション ２−メチルプロパンアミドおよびその医薬としての使用
EP1616874A1 (fr) 2004-07-14 2006-01-18 Universiteit Gent Composés mono- et bicycliques à activité thérapeutique et compositions pharmaceutiques les comprenant
JP2006124326A (ja) 2004-10-28 2006-05-18 Sumitomo Chemical Co Ltd クロピドグレルの製造方法
US7605169B2 (en) 2005-01-25 2009-10-20 Glaxo Group Limited Antibacterial agents
RS52458B (en) 2005-02-04 2013-02-28 Millennium Pharmaceuticals Inc. E1 ENZYMING ENZYME INHIBITORS
JP2006241090A (ja) 2005-03-04 2006-09-14 Tosoh Corp 光学活性カルボン酸類の分離方法
US8802840B2 (en) 2005-03-08 2014-08-12 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
WO2006105127A2 (fr) 2005-03-31 2006-10-05 Takeda San Diego, Inc. Inhibiteurs de l'hydroxysteroide deshydrogenase
WO2007002057A1 (fr) 2005-06-20 2007-01-04 Schering Corporation Pipéridines substituées liées à un atome de carbone et leurs dérivés utiles en tant qu’antagonistes de l'histamine h3
JP2008546784A (ja) 2005-06-20 2008-12-25 シェーリング コーポレイション ヒスタミンｈ３アンタゴニストとして有用なピペリジン誘導体
DE102005059892A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag Alkylthio-spirocyclische Tetramsäuren
DE102005059891A1 (de) 2005-12-15 2007-06-28 Bayer Cropscience Ag 3'-Alkoxy-spirocyclopentyl substituierte Tetram- und Tetronsäuren
ES2684120T3 (es) 2005-12-20 2018-10-01 Novartis Ag Combinación de un inhibidor de IAP y un taxano
BRPI0620386A2 (pt) 2005-12-21 2011-12-20 Schering Corp composição compreendendo a combinação de um antagonista de h3/agonista inverso e um supressor de apetite e uso da referida composição
CA2648884C (fr) 2006-04-24 2015-10-13 Allergan, Inc. Cannabidiols anormaux utiles comme agents destines a faire baisser la pression intraoculaire
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
WO2008019124A1 (fr) 2006-08-08 2008-02-14 Millennium Pharmaceuticals, Inc. Composés hétéroaryles utiles comme inhibiteurs des enzymes d'activation e1
PT2089024E (pt) 2006-11-28 2011-08-31 Novartis Ag Combinação de inibidores de iap e inibidores de flt3
DE102006056740A1 (de) 2006-12-01 2008-06-05 Bayer Healthcare Ag Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung
CN101195586A (zh) 2006-12-05 2008-06-11 中国科学院上海药物研究所 一类具有取代环戊烷结构的化合物、制备方法及其医学用途
JP2010513357A (ja) 2006-12-22 2010-04-30 ノバルティス アーゲー Ｄｐｐ−ｉｖ阻害剤としての１−アミノメチル−１−フェニル−シクロヘキサン誘導体
US8133895B2 (en) 2007-05-10 2012-03-13 Janssen Pharmaceutica N.V. Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
RU2553476C2 (ru) 2007-08-02 2015-06-20 Миллениум Фармасьютикалз, Инк. Способ синтеза ингибиторов е1-активирующего фермента
US8598165B2 (en) 2007-11-26 2013-12-03 University Of Kansas Morpholines as selective inhibitors of cytochrome P450 2A13
WO2009124103A2 (fr) 2008-04-02 2009-10-08 Schering Corporation Thérapies de combinaison comprenant des antagonistes de récepteur 1 activé par protéase (par1) associés à des antagonistes récepteur 4 activé par protéase (par4)
CA2721586A1 (fr) 2008-04-15 2009-10-22 Mallinckrodt Inc. Compositions contenant des composes antiviraux et leurs procedes d'utilisation
WO2009132453A1 (fr) 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Dérivés de cyclylamine utilisés comme agents bloquant le canal calcique
WO2010030858A1 (fr) 2008-09-15 2010-03-18 Enanta Pharmaceuticals, Inc. Dérivés de nucléosides 4'-allène-substitués
BRPI0919977A2 (pt) 2008-10-30 2015-08-25 Oncotherapy Science Inc Derivados de 7-hidróxi-benzoimidazol-4-il-metanona e inibidores de pbk contendo os mesmos
US8722082B2 (en) 2008-11-10 2014-05-13 Tekmira Pharmaceuticals Corporation Lipids and compositions for the delivery of therapeutics
CA2744012A1 (fr) 2008-11-20 2010-05-27 Oncotherapy Science, Inc. Inhibiteurs de glycogene synthase kinase-3 beta contenant des derives de 7-hydroxy-benzoimidazol-4-yl-methanone
CA2751458C (fr) 2009-02-06 2018-06-05 Rfs Pharma, Llc Promedicaments a base de purine nucleoside monophosphate pour le traitement du cancer et des infections virales
BRPI1009324A2 (pt) 2009-03-20 2015-11-24 Alios Biopharma Inc compostos e/ou farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e respectivos usos
EP2264169A1 (fr) 2009-06-15 2010-12-22 Qiagen GmbH SiNA modifié
WO2011005595A2 (fr) 2009-06-24 2011-01-13 Alios Biopharma, Inc. Analogues de 2-5a et leurs procédés d'utilisation
WO2011005860A2 (fr) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. Mimétiques de 5' phosphate
KR101049260B1 (ko) 2009-07-23 2011-07-13 주식회사 엘지화학 새로운 포스트 메탈로센형 전이금속 화합물
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
TW201118099A (en) 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
CN102498111A (zh) 2009-09-10 2012-06-13 诺瓦提斯公司 作为Bcl-2家族蛋白抑制剂用于癌症的治疗的磺酰胺化合物
WO2011057204A2 (fr) 2009-11-06 2011-05-12 The Johns Hopkins University Toxicité neuronale médiée par lrrk2
WO2011061590A1 (fr) 2009-11-17 2011-05-26 Hetero Research Foundation Nouveaux dérivés carboxamides comme inhibiteurs du vih
WO2011066482A2 (fr) 2009-11-25 2011-06-03 Cytokine Pharmasciences, Inc. Synthèse chirale d'isoxazolines, composés d'isoxazoline et utilisations de ceux-ci
BR112012018374B1 (pt) 2009-12-18 2021-09-21 Epics Therapeutics Derivados de ácido carboxílico de pirrolidina ou tiazolidina para distúrbios metabólicos como agonistas de receptor 43 acoplado à proteína g (gpr43), seu processo de preparação e composição farmacêutica
WO2011103441A1 (fr) 2010-02-18 2011-08-25 Schering Corporation Dérivés de pyridine et pyrimidine substitués et leur utilisation dans le traitement d'infections virales
WO2011133871A2 (fr) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. Dérivés d'extrémité 5'
KR101213733B1 (ko) 2010-04-23 2012-12-18 주식회사 엘지화학 신규한 촉매조성물 및 이를 이용한 올레핀 중합체의 제조방법
JP2013147430A (ja) 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
KR20110123657A (ko) 2010-05-07 2011-11-15 에스케이케미칼주식회사 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물
MX2012013879A (es) 2010-06-01 2013-04-03 Biotheryx Inc Derivados de hidroxipiridona, composiciones farmceuticas de los mismos y su uso terapeutico para tratar enfermedades proliferativas.
WO2012025857A1 (fr) 2010-08-23 2012-03-01 Hetero Research Foundation Dérivés de cycloalkyl méthoxybenzyl phényl pyrane en tant qu'inhibiteurs du cotransporteur de glucose sodium-dépendant (sglt2)
CA2810071A1 (fr) 2010-09-03 2012-03-08 Gruenenthal Gmbh Derives de tetrahydropyrrolopyrazines substituees
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
US20120070411A1 (en) 2010-09-22 2012-03-22 Alios Biopharma, Inc. Substituted nucleotide analogs
EP2621923B1 (fr) 2010-09-29 2017-03-29 Intervet International B.V. Composés n-hétéroarylés ayant une unité pontante cyclique pour le traitement de maladies parasitaires
CN103391939B (zh) 2010-12-03 2016-03-09 Epizyme股份有限公司 作为表观遗传酶调节剂的经取代的嘌呤和7-氮杂嘌呤化合物
CN103391931A (zh) 2011-02-25 2013-11-13 辉瑞有限公司 治疗肝纤维化的方法
EP2508511A1 (fr) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques
AR088140A1 (es) 2011-07-19 2014-05-14 Univ Idaho Sonda y metodo para direccionar acidos nucleicos
CN102924457A (zh) 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
BR112014006840A2 (pt) 2011-09-22 2017-04-04 Pfizer derivados de pirrolopirimidina e purina
CN103102345B (zh) 2011-11-14 2015-06-03 广东东阳光药业有限公司 氨基喹唑啉类衍生物及其盐和使用方法
WO2013096939A1 (fr) 2011-12-23 2013-06-27 Sri International Composés de liaison sélective
WO2013120040A1 (fr) 2012-02-10 2013-08-15 Children's Medical Center Corporation Inhibition d'une voie ciblée pour améliorer la structure, le fonctionnement et l'activité musculaires dans la dystrophie musculaire
WO2013151975A1 (fr) 2012-04-02 2013-10-10 Northeastern University Compositions et procédés d'inhibition de méthyltransférases
US9809616B2 (en) 2012-10-29 2017-11-07 Emory University Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer
WO2013188881A1 (fr) 2012-06-15 2013-12-19 President And Fellows Of Harvard College Composés, compositions et méthodes de traitement ou de prévention de troubles neurodégénératifs
AR092348A1 (es) 2012-07-11 2015-04-15 Hoffmann La Roche DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc
WO2014026198A1 (fr) 2012-08-10 2014-02-13 Epizyme, Inc. Inhibiteurs de protéine méthyltransférase de dot1l et leurs procédés d'utilisation
US9340538B2 (en) 2012-08-24 2016-05-17 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
RU2015125591A (ru) 2012-12-10 2017-01-16 Ф. Хоффманн-Ля Рош Аг БЕНЗИЛСУЛЬФОНАМИДНЫЕ ПРОИЗВОДНЫЕ КАК МОДУЛЯТОРЫ RORc
EP2968233A4 (fr) 2013-03-14 2016-08-03 Chdi Foundation Inc Inhibiteurs d'histone désacétylase, et compositions et méthodes d'utilisation associées
EP2968343A4 (fr) 2013-03-14 2016-11-02 Epizyme Inc Polythérapie pour traiter un cancer
MX364438B (es) 2013-03-15 2019-04-26 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
DK2989098T3 (en) 2013-03-15 2017-08-28 Cayman Chemical Co Inc LACTAM RELATIONS AS EP4 RECEPTOR SELECTIVE AGONISTS FOR USING THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
WO2015077360A2 (fr) 2013-11-20 2015-05-28 Idenix Pharmaceuticals, Inc. Analogues nucléosidiques renfermant un cyclopentane ou un cyclopentène pour le traitement de l'hépatite c
TWI608080B (zh) 2014-01-29 2017-12-11 達興材料股份有限公司 液晶化合物、液晶組成物以及液晶顯示元件
MA39317A1 (fr) * 2014-02-06 2018-01-31 Riboscience Llc Dérivés de nucléosides à substitution 4'-difluorométhyle utilisés en tant qu'inhibiteurs de la réplication de l'arn du virus de la grippe
EP3145912A1 (fr) 2014-05-23 2017-03-29 F. Hoffmann-La Roche AG Dérivés de benzène sulfonamide et leur utilisation comme modulateurs de rorc
CN104059674B (zh) 2014-06-06 2016-01-20 北京八亿时空液晶科技股份有限公司 一种含有二氟甲氧基桥键的液晶化合物及其应用
CN104087312B (zh) 2014-06-17 2016-07-06 北京八亿时空液晶科技股份有限公司 一种液晶组合物及其应用
EP3160475B1 (fr) * 2014-06-24 2024-01-03 Janssen Pharmaceuticals, Inc. Nucléosides et nucléotides substitués pour traiter les infections dues aux filoviridae
AR101214A1 (es) 2014-07-22 2016-11-30 Bayer Cropscience Ag Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas
KR20170033339A (ko) 2014-07-31 2017-03-24 메르크 파텐트 게엠베하 새로운 인돌리진 유도체 및 신경변성 질환에서의 이들의 용도
WO2016024185A1 (fr) 2014-08-12 2016-02-18 Pfizer Inc. Dérivés de pyrrolo[2,3-d]pyrimidine utiles pour inhiber la janus kinase
JP2017532312A (ja) 2014-09-17 2017-11-02 エピザイム，インコーポレイティド 癌を治療するための併用療法
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049524A1 (fr) 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibiteurs de protéines mutantes kras g12c
WO2016049565A1 (fr) 2014-09-25 2016-03-31 Araxes Pharma Llc Compositions et procédés pour inhiber la ras
AU2015320511B2 (en) * 2014-09-26 2020-11-12 Riboscience Llc 4'-vinyl substituted nucleoside derivatives as inhibitors of Respiratory Syncytial Virus RNA replication
EP3212201B1 (fr) 2014-10-28 2022-10-19 BCI Pharma Inhibiteurs de la kinase nucléoside
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
US10767112B2 (en) 2015-01-15 2020-09-08 The Trustees Of The Columbia University In The City Of New York Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control
WO2016145142A1 (fr) 2015-03-10 2016-09-15 Emory University Compositions thérapeutiques renfermant des nucléotides et des nucléosides et utilisations associées
FR3034767A1 (fr) 2015-04-07 2016-10-14 Centre Nat Rech Scient Reduction des fonctions carbonyles de glucides et derives de glucides en milieu aqueux par le dithionite de sodium
US10590070B2 (en) 2015-08-10 2020-03-17 Alzheon, Inc. Compositions and methods for treating and preventing neurodegenerative disorders
TWI791251B (zh) 2015-08-26 2023-02-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物
US9926277B2 (en) 2015-10-02 2018-03-27 Biotheryx, Inc. Pyridone compounds, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases
US11433047B2 (en) 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
US11866754B2 (en) 2015-10-16 2024-01-09 Modernatx, Inc. Trinucleotide mRNA cap analogs
EP3362460A1 (fr) 2015-10-16 2018-08-22 Modernatx, Inc. Analogues de coiffes arnm et procédés de coiffage d'arnm
WO2017066782A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffes d'arnm hydrophobes
WO2017066791A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm à substitution sucre
WO2017066789A1 (fr) 2015-10-16 2017-04-20 Modernatx, Inc. Analogues de coiffe d'arnm avec sucre modifié
US20190218546A1 (en) 2015-10-16 2019-07-18 Modernatx, Inc. Mrna cap analogs with modified phosphate linkage
WO2017099969A1 (fr) 2015-12-10 2017-06-15 Merck Sharp & Dohme Corp. Modulateurs allostériques positifs du récepteur muscarinique m1 tétrahydroquinoxaline
WO2017117433A1 (fr) 2015-12-31 2017-07-06 Braskem America, Inc. Système de catalyseur de type non-phtalate et son utilisation dans la polymérisation des oléfines
EP3426664B1 (fr) 2016-03-10 2021-06-30 Janssen Pharmaceutica NV Analogues de nucléoside substitués pour une utilisation en tant qu'inhibiteurs de prmt5
CA2969295A1 (fr) 2016-06-06 2017-12-06 Pfizer Inc. Derives de carbonucleosides substitues et leur utilisation comme inhibiteur de prmt5
WO2017211307A1 (fr) 2016-06-08 2017-12-14 四川海思科制药有限公司 Dérivé de benzène, procédé de préparation et application pharmaceutique associés
US10035789B2 (en) 2016-07-27 2018-07-31 Blueprint Medicines Corporation Compounds useful for treating disorders related to RET
WO2018024188A1 (fr) 2016-08-02 2018-02-08 上海迪诺医药科技有限公司 Composé polycyclique et procédé de fabrication, composition pharmaceutique et application de celui-ci
CN107674029A (zh) 2016-08-02 2018-02-09 上海迪诺医药科技有限公司 多环化合物、其药物组合物及应用
CN107793409B (zh) 2016-09-05 2022-09-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
WO2018065353A1 (fr) 2016-10-03 2018-04-12 Umicore Ag & Co. Kg Article catalyseur et procédé de réduction d'ammoniac et d'oxydes d'azote
WO2018065365A1 (fr) * 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Nouveaux analogues de carbanucléoside substitués par un système cyclique, monocyclique et bicyclique destinés à être utilisés en tant qu'inhibiteurs de prmt5
JP2018070512A (ja) 2016-10-31 2018-05-10 住友化学株式会社 有害節足動物防除組成物
WO2018081863A1 (fr) 2016-11-04 2018-05-11 University Of Wollongong Dérivés à substitution en position 6 de l'hexaméthylène amiloride en tant qu'inhibiteurs de upa et leurs utilisations
WO2018085818A1 (fr) * 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
CN108276463A (zh) 2017-01-06 2018-07-13 米文君 一类新的化合物及其用途
WO2018152548A1 (fr) 2017-02-20 2018-08-23 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
WO2018152501A1 (fr) 2017-02-20 2018-08-23 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
ES2971035T3 (es) 2017-02-27 2024-06-03 Janssen Pharmaceutica Nv Uso de biomarcadores en la identificación de pacientes con cáncer que mostrarán respuesta al tratamiento con un inhibidor de prmt5
WO2018160824A1 (fr) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Inhibiteurs sélectifs de la protéine arginine méthyltransférase 5 (prmt5)
EP3592739A1 (fr) 2017-03-07 2020-01-15 H. Hoffnabb-La Roche Ag Oxadiazole en tant qu'inhibiteurs de canaux potentiels de récepteur transitoire
WO2018213258A1 (fr) 2017-05-15 2018-11-22 Millennium Pharmaceuticals, Inc. Traitement de tumeurs déficientes en merlin à l'aide d'inhibiteurs de nae
JP7088965B2 (ja) 2017-06-09 2022-06-21 ブリストル－マイヤーズ スクイブ カンパニー アリール複素環ピペリジノンホルミルペプチド２受容体およびホルミルペプチド１受容体アゴニスト
AU2018381004B2 (en) 2017-12-05 2021-04-29 Angex Pharmaceutical, Inc. Heterocyclic compounds as PRMT5 inhibitors
RS63623B1 (sr) * 2017-12-13 2022-10-31 Lupin Ltd Supstituisana biciklična heterociklična jedinjenja kao inhibitori prmt5
KR20190076339A (ko) 2017-12-22 2019-07-02 한미약품 주식회사 신규한 2,6-나프티리딘 2-옥시드 유도체 화합물 및 이의 용도
WO2019177873A1 (fr) 2018-03-13 2019-09-19 Merck Sharp & Dohme Corp. Inhibiteurs d'arginase et procédés d'utilisation
CN110386954B (zh) 2018-04-16 2020-08-21 中国科学院化学研究所 含不对称稠环吡啶亚胺基配合物及其制备方法与应用
SG11202010790XA (en) 2018-04-30 2020-11-27 Oric Pharmaceuticals Inc Cd73 inhibitors
US11981701B2 (en) 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors
EP3833668A4 (fr) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
CA3108388A1 (fr) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
EP3833669A4 (fr) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. Inhibiteurs de prmt5
CN113473985A (zh) 2018-09-18 2021-10-01 百时美施贵宝公司 作为lpa拮抗剂的环戊酸
AU2020256166A1 (en) * 2019-04-02 2021-10-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
CN110423265A (zh) 2019-04-03 2019-11-08 中国药科大学 一种环肽类trf2抑制剂的制备方法和用途

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US11198699B2 (en) 2021-12-14
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CA3134613A1 (fr) 2020-10-08
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