BR0312286A - pró-medicamentos de 2' e 3' - nucleosìdeo modificado para tratamento de infecções por flaviviridae - Google Patents
pró-medicamentos de 2' e 3' - nucleosìdeo modificado para tratamento de infecções por flaviviridaeInfo
- Publication number
- BR0312286A BR0312286A BRPI0312286-7A BR0312286A BR0312286A BR 0312286 A BR0312286 A BR 0312286A BR 0312286 A BR0312286 A BR 0312286A BR 0312286 A BR0312286 A BR 0312286A
- Authority
- BR
- Brazil
- Prior art keywords
- prodrugs
- flaviviridae infections
- treatment
- modified nucleoside
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Abstract
PRó-MEDICAMENTOSDE 2' E 3' - NUCLEOSìDEO MODIFICADO PARA TRATAMENTO DE INFEçõES POR FLAVIVIRIDAE São descritos pró-medicamentos 2' e/ou 3' de 1', 2', 3' ou 4' -nucleosídeos ramificados, e seus sais farmaceuticamente aceitáveis e derivados. Esses pró-medicamentos são úteis na prevenção e tratamento de infecções por Flaviviridae, incluindo infecção por HCV, e outros problemas médicos relacionados. São descritos compostos e composições dos pró-medicamentos da presente invenção. Também são fornecidos métodos e usos que incluem a administração de uma quantidade eficaz dos pró-medicamentos da presente invenção, ou de seus sais ou derivados farmaceuticamente aceitáveis. Esses medicamentos podem opcionalmente ser administrados em combinação ou alternância com agente antivirais adicionais para evitar ou tratar infecções por Flaviviridae e outros problemas médicos relacionados.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39235002P | 2002-06-28 | 2002-06-28 | |
US39235102P | 2002-06-28 | 2002-06-28 | |
US46619403P | 2003-04-28 | 2003-04-28 | |
US47094903P | 2003-05-14 | 2003-05-14 | |
PCT/IB2003/003246 WO2004002999A2 (en) | 2002-06-28 | 2003-06-27 | Modified 2' and 3' -nucleoside produgs for treating flaviridae infections |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312286A true BR0312286A (pt) | 2007-06-19 |
Family
ID=30003988
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0312286-7A BR0312286A (pt) | 2002-06-28 | 2003-06-27 | pró-medicamentos de 2' e 3' - nucleosìdeo modificado para tratamento de infecções por flaviviridae |
BRPI0312271-9A BR0312271A (pt) | 2002-06-28 | 2003-06-27 | compostos, composições e seus usos para o tratamento de infecções por flaviviridae |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0312271-9A BR0312271A (pt) | 2002-06-28 | 2003-06-27 | compostos, composições e seus usos para o tratamento de infecções por flaviviridae |
Country Status (27)
Country | Link |
---|---|
EP (3) | EP2799442A1 (pt) |
JP (7) | JP2005533817A (pt) |
KR (1) | KR20050048544A (pt) |
CN (6) | CN103319554A (pt) |
AP (1) | AP2005003212A0 (pt) |
AR (2) | AR043101A1 (pt) |
AU (1) | AU2003247084B9 (pt) |
BR (2) | BR0312286A (pt) |
CA (1) | CA2490191C (pt) |
CY (2) | CY1115417T1 (pt) |
DE (1) | DE14169110T1 (pt) |
DK (1) | DK1523489T3 (pt) |
ES (1) | ES2469569T3 (pt) |
HK (3) | HK1204624A1 (pt) |
IL (1) | IL165893A0 (pt) |
MA (1) | MA27375A1 (pt) |
MX (1) | MXPA04012709A (pt) |
MY (1) | MY140819A (pt) |
NO (3) | NO330755B1 (pt) |
PE (3) | PE20040636A1 (pt) |
PL (1) | PL374831A1 (pt) |
PT (1) | PT1523489E (pt) |
RS (1) | RS114004A (pt) |
RU (1) | RU2483075C2 (pt) |
TW (3) | TW200500375A (pt) |
UY (3) | UY27874A1 (pt) |
WO (1) | WO2004002999A2 (pt) |
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