EP0746319A4 - Acyclovir derivatives for topical use - Google Patents

Acyclovir derivatives for topical use

Info

Publication number
EP0746319A4
EP0746319A4 EP93913832A EP93913832A EP0746319A4 EP 0746319 A4 EP0746319 A4 EP 0746319A4 EP 93913832 A EP93913832 A EP 93913832A EP 93913832 A EP93913832 A EP 93913832A EP 0746319 A4 EP0746319 A4 EP 0746319A4
Authority
EP
European Patent Office
Prior art keywords
topical use
acyclovir derivatives
acyclovir
derivatives
topical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93913832A
Other languages
German (de)
French (fr)
Other versions
EP0746319A1 (en
Inventor
Karl Y Hostetler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0746319A1 publication Critical patent/EP0746319A1/en
Publication of EP0746319A4 publication Critical patent/EP0746319A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP93913832A 1993-05-12 1993-05-12 Acyclovir derivatives for topical use Withdrawn EP0746319A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004450 WO1994026273A1 (en) 1993-05-12 1993-05-12 Acyclovir derivatives for topical use

Publications (2)

Publication Number Publication Date
EP0746319A1 EP0746319A1 (en) 1996-12-11
EP0746319A4 true EP0746319A4 (en) 1997-11-05

Family

ID=22236586

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93913832A Withdrawn EP0746319A4 (en) 1993-05-12 1993-05-12 Acyclovir derivatives for topical use

Country Status (5)

Country Link
EP (1) EP0746319A4 (en)
JP (1) JPH08510236A (en)
AU (1) AU701574B2 (en)
CA (1) CA2162574A1 (en)
WO (1) WO1994026273A1 (en)

Families Citing this family (39)

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US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5576313A (en) * 1994-08-29 1996-11-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU722214B2 (en) 1995-06-07 2000-07-27 Centre National De La Recherche Scientifique (Cnrs) Nucleosides with anti-hepatitis B virus activity
US6242474B1 (en) * 1997-06-27 2001-06-05 Fujisawa Pharmaceutical Co., Ltd. Aromatic ring derivatives
ES2276515T3 (en) 1998-02-25 2007-06-16 Emory University 2'-FLUORONUCLEOSIDS.
MXPA01001507A (en) 1998-08-10 2003-09-10 Novirio Pharmaceuticals Ltd beta-L-2'-DEOXY-NUCLEOSIDES FOR THE TREATMENT OF HEPATITIS B.
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
ATE287268T1 (en) 1998-11-02 2005-02-15 Gilead Sciences Inc COMBINATION THERAPY FOR THE TREATMENT OF HEPATITIS B INFECTIONS
ATE339211T1 (en) 2000-03-29 2006-10-15 Univ Georgetown L-FMAU FOR THE TREATMENT OF HEPATITIS DELTA VIRUS INFECTION
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
JP5230052B2 (en) 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド Methods and compositions for the treatment of flaviviruses and pestiviruses
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
EP1411954B1 (en) 2000-10-18 2010-12-15 Pharmasset, Inc. Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
CA2690137C (en) 2001-03-01 2012-11-13 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
TW200500374A (en) 2002-06-28 2005-01-01 Idenlx Cayman Ltd 2' and 3' -nucleoside produrgs for treating flavivridae infections
WO2004002422A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
WO2004024095A2 (en) 2002-09-13 2004-03-25 Idenix (Cayman) Limited ß-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
CA2506129C (en) 2002-11-15 2015-02-17 Idenix (Cayman) Limited 2'-branched nucleosides and flaviviridae mutation
WO2005003147A2 (en) 2003-05-30 2005-01-13 Pharmasset, Inc. Modified fluorinated nucleoside analogues
WO2005009418A2 (en) 2003-07-25 2005-02-03 Idenix (Cayman) Limited Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c
ES2629682T3 (en) 2004-03-29 2017-08-14 University Of South Florida Effective treatment of tumors and cancer with triciribin phosphate
SI3109244T1 (en) 2004-09-14 2019-06-28 Gilead Pharmasset Llc Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
ES2617582T3 (en) 2005-09-26 2017-06-19 Gilead Pharmasset Llc 4'-Nucleosides modified as antiviral agents
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
EP2268288A4 (en) 2008-04-15 2012-05-30 Rfs Pharma Llc Nucleoside derivatives for treatment of caliciviridae infections, including norovirus infections
CL2009002207A1 (en) 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compounds derived from 3-hydroxy-5- (9h-purin-9-yl) tetrahydrofuran-2-yl, an inhibitor of the replication of arn-dependent viral arn; pharmaceutical composition; use for the treatment of hepatitis c.
WO2010075517A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (en) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 Nucleoside phosphoramidates
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
JP6069215B2 (en) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー Compound
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CA3131037A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
ES2900570T3 (en) 2013-08-27 2022-03-17 Gilead Pharmasset Llc Combination formulation of two antiviral compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457253A (en) * 1965-06-01 1969-07-22 Upjohn Co 5',5'-di-(ara)-nucleoside phosphates
EP0095813A2 (en) * 1982-06-01 1983-12-07 THE PROCTER & GAMBLE COMPANY Penetrating topical pharmaceutical compositions containing 9-(2-hydroxyethoxymethyl) guanine
EP0121635A1 (en) * 1982-12-03 1984-10-17 Synthelabo 3',5',-Diarabinosides, their preparation and their therapeutical application
EP0165164A1 (en) * 1984-06-06 1985-12-18 Merck & Co. Inc. Anti-viral compounds, their preparation and anti-viral compositions
DE3543346A1 (en) * 1984-12-07 1986-06-12 Boryung Pharmaceutical Co., Ltd., Seoul NEW NUCLEOSIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
EP0350287A2 (en) * 1988-07-07 1990-01-10 NeXstar Pharmaceuticals, Inc. Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
EP0381533A2 (en) * 1989-02-02 1990-08-08 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457253A (en) * 1965-06-01 1969-07-22 Upjohn Co 5',5'-di-(ara)-nucleoside phosphates
EP0095813A2 (en) * 1982-06-01 1983-12-07 THE PROCTER & GAMBLE COMPANY Penetrating topical pharmaceutical compositions containing 9-(2-hydroxyethoxymethyl) guanine
EP0121635A1 (en) * 1982-12-03 1984-10-17 Synthelabo 3',5',-Diarabinosides, their preparation and their therapeutical application
EP0165164A1 (en) * 1984-06-06 1985-12-18 Merck & Co. Inc. Anti-viral compounds, their preparation and anti-viral compositions
DE3543346A1 (en) * 1984-12-07 1986-06-12 Boryung Pharmaceutical Co., Ltd., Seoul NEW NUCLEOSIDE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
EP0350287A2 (en) * 1988-07-07 1990-01-10 NeXstar Pharmaceuticals, Inc. Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
EP0381533A2 (en) * 1989-02-02 1990-08-08 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DARBY G. ET AL: "Sensitivity of Viruses to Phosphorylated 9-(2-hydroxyehtoxymethyl)guanine Revealed in TK-transformed cells", J. GEN. VIROL. (ENGLAND), vol. 48, no. 2, 1980, pages 451 - 454, XP000654218 *
PRISBE E.J. ET AL: "Synthesis and Antiherpes Virus Activity of Phosphate and Phosphonate Derivatives of 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine", J. MED. CHEM., vol. 29, 1986, pages 671 - 675, XP002035409 *
See also references of WO9426273A1 *

Also Published As

Publication number Publication date
EP0746319A1 (en) 1996-12-11
AU701574B2 (en) 1999-02-04
JPH08510236A (en) 1996-10-29
WO1994026273A1 (en) 1994-11-24
AU4372193A (en) 1994-12-12
CA2162574A1 (en) 1994-11-24

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Legal Events

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