BRPI0008614B8 - composto inibidor tricíclico de poli(adp-ribose) polimerase, e composição farmacêuticas contendo tal composto. - Google Patents

composto inibidor tricíclico de poli(adp-ribose) polimerase, e composição farmacêuticas contendo tal composto.

Info

Publication number
BRPI0008614B8
BRPI0008614B8 BRPI0008614A BR0008614A BRPI0008614B8 BR PI0008614 B8 BRPI0008614 B8 BR PI0008614B8 BR PI0008614 A BRPI0008614 A BR PI0008614A BR 0008614 A BR0008614 A BR 0008614A BR PI0008614 B8 BRPI0008614 B8 BR PI0008614B8
Authority
BR
Brazil
Prior art keywords
poly
compound
adp
ribose
tricyclic
Prior art date
Application number
BRPI0008614A
Other languages
English (en)
Other versions
BR0008614B1 (pt
BR0008614A (pt
Inventor
Girish Tikhe Jayashree
Henrik Thoresen Lars
S Canan-Koch Stacie
Evan Webber Stephen
Original Assignee
Agouron Pharma
Cancer Research Tech Ltd
Cancer Research Campaign Tech Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma, Cancer Research Tech Ltd, Cancer Research Campaign Tech Limited filed Critical Agouron Pharma
Publication of BR0008614A publication Critical patent/BR0008614A/pt
Publication of BR0008614B1 publication Critical patent/BR0008614B1/pt
Publication of BRPI0008614B8 publication Critical patent/BRPI0008614B8/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"compostos inibidores tricíclicos de poli(adp-ribose) polimerases, seus sais, pró-medicamentos, metabólitos ativos, ou solvatos farmaceuticamente aceitáveis, composições farmacêuticas, métodos de inibição da atividade de parp de uma enzima e metodos de inibição da atividade de enzima parp em tecido de mamífero". compostos da fórmula (i) são inibidores da poli(adpribosil)transferase (parp), e são úteis como agentes terapêuticos no tratamento do câncer e na melhora dos efeitos de acidente vascular cerebral, traumatismo craniano e doença neurodegenerativa. como agentes terapêuticos para o câncer , os compostos da invenção podem ser utilizados, por exemplo, em combinação com agentes citotóxicos e/ou radiação.
BRPI0008614A 1999-01-11 2000-01-10 composto inibidor tricíclico de poli(adp-ribose) polimerase, e composição farmacêuticas contendo tal composto. BRPI0008614B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11543199P 1999-01-11 1999-01-11
US60/115,431 1999-01-11
PCT/US2000/000411 WO2000042040A1 (en) 1999-01-11 2000-01-10 Tricyclic inhibitors of poly(adp-ribose) polymerases

Publications (3)

Publication Number Publication Date
BR0008614A BR0008614A (pt) 2001-10-16
BR0008614B1 BR0008614B1 (pt) 2014-11-25
BRPI0008614B8 true BRPI0008614B8 (pt) 2021-05-25

Family

ID=22361361

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0008614A BRPI0008614B8 (pt) 1999-01-11 2000-01-10 composto inibidor tricíclico de poli(adp-ribose) polimerase, e composição farmacêuticas contendo tal composto.

Country Status (40)

Country Link
US (4) US6495541B1 (pt)
EP (1) EP1140936B1 (pt)
JP (1) JP4093448B2 (pt)
KR (1) KR100632079B1 (pt)
CN (1) CN100418967C (pt)
AP (1) AP1538A (pt)
AT (1) ATE261963T1 (pt)
AU (1) AU781711B2 (pt)
BG (1) BG65210B1 (pt)
BR (1) BRPI0008614B8 (pt)
CA (1) CA2360003C (pt)
CZ (1) CZ302941B6 (pt)
DE (1) DE60009033T2 (pt)
DK (1) DK1140936T3 (pt)
EA (1) EA004989B1 (pt)
EE (1) EE05006B1 (pt)
ES (1) ES2218110T3 (pt)
GE (1) GEP20033055B (pt)
HK (1) HK1040992A1 (pt)
HR (1) HRP20010573B1 (pt)
HU (1) HU229875B1 (pt)
ID (1) ID30138A (pt)
IL (2) IL144112A0 (pt)
IS (1) IS5995A (pt)
LT (1) LT4936B (pt)
LV (1) LV12770B (pt)
MX (1) MXPA01007001A (pt)
NO (1) NO320343B1 (pt)
NZ (1) NZ512731A (pt)
OA (2) OA11749A (pt)
PL (1) PL210415B1 (pt)
PT (1) PT1140936E (pt)
RO (1) RO121778B1 (pt)
RS (1) RS50031B (pt)
SI (1) SI20691B (pt)
SK (1) SK287338B6 (pt)
TR (1) TR200102005T2 (pt)
UA (1) UA75034C2 (pt)
WO (1) WO2000042040A1 (pt)
ZA (1) ZA200105399B (pt)

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