JPS6434988A - Azepinoindole derivative - Google Patents

Azepinoindole derivative

Info

Publication number
JPS6434988A
JPS6434988A JP62191435A JP19143587A JPS6434988A JP S6434988 A JPS6434988 A JP S6434988A JP 62191435 A JP62191435 A JP 62191435A JP 19143587 A JP19143587 A JP 19143587A JP S6434988 A JPS6434988 A JP S6434988A
Authority
JP
Japan
Prior art keywords
formula
compound
action
remedy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62191435A
Other languages
Japanese (ja)
Inventor
Masanori Somei
Toshiharu Ota
Masayuki Wakita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Priority to JP62191435A priority Critical patent/JPS6434988A/en
Publication of JPS6434988A publication Critical patent/JPS6434988A/en
Pending legal-status Critical Current

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I (R<1> is H, 2-6C alkyl or 2-6C acyl; R<2> is H or 1-3C alkyl; compound wherein both R<1> and R<2> are H is omitted). EXAMPLE:5-Ethyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole. USE:Having diuretic action, heart suppressing action, relaxing action on smooth muscle and sleep prolonging action, useful as a remedy for circulatory diseases, remedy for alimentary diseases and psychotropic agent. PREPARATION:A 4-cyanoindole derivative shown by formula II is hydrolyzed with a base such as triton B and subjected to ring closure to produce a compound shown by formula III. Then this compound is reduced with a reducing agent such as lithium aluminum hydride. The starting raw material shown by formula II is produced by reacting a compound shown by formula IV with a nitroalkane, hydrogenating and reducing the reaction product.
JP62191435A 1987-07-30 1987-07-30 Azepinoindole derivative Pending JPS6434988A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62191435A JPS6434988A (en) 1987-07-30 1987-07-30 Azepinoindole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62191435A JPS6434988A (en) 1987-07-30 1987-07-30 Azepinoindole derivative

Publications (1)

Publication Number Publication Date
JPS6434988A true JPS6434988A (en) 1989-02-06

Family

ID=16274571

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62191435A Pending JPS6434988A (en) 1987-07-30 1987-07-30 Azepinoindole derivative

Country Status (1)

Country Link
JP (1) JPS6434988A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042040A1 (en) * 1999-01-11 2000-07-20 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
JP2003502426A (en) * 1999-06-17 2003-01-21 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Indoloazepines as vasopressin receptor antagonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144286A (en) * 1981-03-02 1982-09-06 Takeda Chem Ind Ltd Azepinoindole derivative and its preparation
JPS6125278A (en) * 1984-07-12 1986-02-04 Matsushita Electric Ind Co Ltd Real time three dimensional image process device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144286A (en) * 1981-03-02 1982-09-06 Takeda Chem Ind Ltd Azepinoindole derivative and its preparation
JPS6125278A (en) * 1984-07-12 1986-02-04 Matsushita Electric Ind Co Ltd Real time three dimensional image process device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042040A1 (en) * 1999-01-11 2000-07-20 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
US6977298B2 (en) 1999-01-11 2005-12-20 Agouron Pharmacetucals, Inc. Tricyclic inhibitors of poly(ADP-ribose) polymerases
US7429578B2 (en) 1999-01-11 2008-09-30 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(ADP-ribose) polymerases
JP2003502426A (en) * 1999-06-17 2003-01-21 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Indoloazepines as vasopressin receptor antagonists

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