JPS6434988A - Azepinoindole derivative - Google Patents
Azepinoindole derivativeInfo
- Publication number
- JPS6434988A JPS6434988A JP62191435A JP19143587A JPS6434988A JP S6434988 A JPS6434988 A JP S6434988A JP 62191435 A JP62191435 A JP 62191435A JP 19143587 A JP19143587 A JP 19143587A JP S6434988 A JPS6434988 A JP S6434988A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- action
- remedy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound shown by formula I (R<1> is H, 2-6C alkyl or 2-6C acyl; R<2> is H or 1-3C alkyl; compound wherein both R<1> and R<2> are H is omitted). EXAMPLE:5-Ethyl-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indole. USE:Having diuretic action, heart suppressing action, relaxing action on smooth muscle and sleep prolonging action, useful as a remedy for circulatory diseases, remedy for alimentary diseases and psychotropic agent. PREPARATION:A 4-cyanoindole derivative shown by formula II is hydrolyzed with a base such as triton B and subjected to ring closure to produce a compound shown by formula III. Then this compound is reduced with a reducing agent such as lithium aluminum hydride. The starting raw material shown by formula II is produced by reacting a compound shown by formula IV with a nitroalkane, hydrogenating and reducing the reaction product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62191435A JPS6434988A (en) | 1987-07-30 | 1987-07-30 | Azepinoindole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62191435A JPS6434988A (en) | 1987-07-30 | 1987-07-30 | Azepinoindole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6434988A true JPS6434988A (en) | 1989-02-06 |
Family
ID=16274571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62191435A Pending JPS6434988A (en) | 1987-07-30 | 1987-07-30 | Azepinoindole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6434988A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042040A1 (en) * | 1999-01-11 | 2000-07-20 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
JP2003502426A (en) * | 1999-06-17 | 2003-01-21 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Indoloazepines as vasopressin receptor antagonists |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57144286A (en) * | 1981-03-02 | 1982-09-06 | Takeda Chem Ind Ltd | Azepinoindole derivative and its preparation |
JPS6125278A (en) * | 1984-07-12 | 1986-02-04 | Matsushita Electric Ind Co Ltd | Real time three dimensional image process device |
-
1987
- 1987-07-30 JP JP62191435A patent/JPS6434988A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57144286A (en) * | 1981-03-02 | 1982-09-06 | Takeda Chem Ind Ltd | Azepinoindole derivative and its preparation |
JPS6125278A (en) * | 1984-07-12 | 1986-02-04 | Matsushita Electric Ind Co Ltd | Real time three dimensional image process device |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042040A1 (en) * | 1999-01-11 | 2000-07-20 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
US6977298B2 (en) | 1999-01-11 | 2005-12-20 | Agouron Pharmacetucals, Inc. | Tricyclic inhibitors of poly(ADP-ribose) polymerases |
US7429578B2 (en) | 1999-01-11 | 2008-09-30 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(ADP-ribose) polymerases |
JP2003502426A (en) * | 1999-06-17 | 2003-01-21 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Indoloazepines as vasopressin receptor antagonists |
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