BRPI0508233A - derivados de isoquinolina e métodos para emprego destes - Google Patents

derivados de isoquinolina e métodos para emprego destes

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Publication number
BRPI0508233A
BRPI0508233A BRPI0508233-1A BRPI0508233A BRPI0508233A BR PI0508233 A BRPI0508233 A BR PI0508233A BR PI0508233 A BRPI0508233 A BR PI0508233A BR PI0508233 A BRPI0508233 A BR PI0508233A
Authority
BR
Brazil
Prior art keywords
methods
disease
isoquinoline
isoquinoline derivatives
effective amount
Prior art date
Application number
BRPI0508233-1A
Other languages
English (en)
Inventor
Prakash Jagtap
Erkan Baloglu
John Henry Van Duzer
Csaba Szabo
Andrew L Salzman
Aloka Roy
William Williams
Alexander Nivorozhkin
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of BRPI0508233A publication Critical patent/BRPI0508233A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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    • C07D221/18—Ring systems of four or more rings

Abstract

DERIVADOS DE ISOQUINOLINA E MéTODOS PARA EMPREGO DESTES. A presente invenção refere-se a derivados de isoquinolina, composições compreendendo uma quantidade eficaz de um derivado de isoquinolina e métodos para tratar ou prevenir uma doença inflamatória, uma lesão de reperfusão, uma condição isquêmica, insuficiência renal, diabetes, uma complicação diabética, uma doença vascular, exceto uma doença cardiovascular, lesão de reoxigenação resultante de transplante de órgão, doença de Parkinson, ou câncer, compreedendo administrar a um animal em necessidade deste, uma quantidade eficaz de um derivado de isoquinolina.
BRPI0508233-1A 2004-02-26 2005-02-25 derivados de isoquinolina e métodos para emprego destes BRPI0508233A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54789904P 2004-02-26 2004-02-26
PCT/US2005/006243 WO2005082368A1 (en) 2004-02-26 2005-02-25 Isoquinoline derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0508233A true BRPI0508233A (pt) 2007-07-17

Family

ID=34910959

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508233-1A BRPI0508233A (pt) 2004-02-26 2005-02-25 derivados de isoquinolina e métodos para emprego destes

Country Status (14)

Country Link
US (1) US20050228007A1 (pt)
EP (2) EP1722797A4 (pt)
JP (1) JP2007527872A (pt)
KR (1) KR20060125909A (pt)
CN (1) CN1964716A (pt)
AU (1) AU2005216978A1 (pt)
BR (1) BRPI0508233A (pt)
CA (1) CA2557547A1 (pt)
EA (1) EA200601558A1 (pt)
IL (1) IL177650A0 (pt)
MX (1) MXPA06009701A (pt)
NO (1) NO20064328L (pt)
WO (1) WO2005082368A1 (pt)
ZA (1) ZA200607913B (pt)

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