BRPI0509359A - compostos de porfirina substituìda por piridila e métodos de empregos destes - Google Patents
compostos de porfirina substituìda por piridila e métodos de empregos destesInfo
- Publication number
- BRPI0509359A BRPI0509359A BRPI0509359-7A BRPI0509359A BRPI0509359A BR PI0509359 A BRPI0509359 A BR PI0509359A BR PI0509359 A BRPI0509359 A BR PI0509359A BR PI0509359 A BRPI0509359 A BR PI0509359A
- Authority
- BR
- Brazil
- Prior art keywords
- pyridyl
- substituted porphyrin
- methods
- disease
- cancer
- Prior art date
Links
- -1 porphyrin compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 125000004076 pyridyl group Chemical group 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010058490 Hyperoxia Diseases 0.000 abstract 1
- 206010063837 Reperfusion injury Diseases 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000222 hyperoxic effect Effects 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 239000000203 mixture Chemical class 0.000 abstract 1
- 230000003680 myocardial damage Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
- C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
"COMPOSTOS DE PORFIRINA SUBSTITUìDA POR PIRIDILA E MéTODOS DE EMPREGO DESTES". A presente invenção refere-se aos compostos de Porfirina Substituídos por Piridila, composições compreendendo uma quantidade eficaz de um Composto de Porfirina Substituído por Piridila e métodos para tratamento ou prevenção de dano devido a exposição a uma espécie reativa, disfunção erétil devido a cirurgia, doença de pulmão, hiperoxia, doença neurode generativa, doença de fígado, dano do miocárdio durante cardioplegia, uma condição inflamatória, um dano de reperfusão, uma condição isquêmica, uma doença cardiovascular, diabetes, uma complicação diabética, câncer, um efeito colateral de quimioterapia de câncer, ou um dano induzido por radiação, ou para prolongar a meia-vida de um composto propenso a oxidação, compreendendo administrar a um indivíduo em necessidade deste uma quantidade eficaz de um Composto de Porfirina Substituíido por Piridila.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55755104P | 2004-03-29 | 2004-03-29 | |
US62846504P | 2004-11-16 | 2004-11-16 | |
PCT/US2005/010167 WO2005097123A2 (en) | 2004-03-29 | 2005-03-25 | Pyridyl-substituted porphyrin compounds and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509359A true BRPI0509359A (pt) | 2007-09-04 |
Family
ID=35125604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509359-7A BRPI0509359A (pt) | 2004-03-29 | 2005-03-25 | compostos de porfirina substituìda por piridila e métodos de empregos destes |
Country Status (11)
Country | Link |
---|---|
US (2) | US7432369B2 (pt) |
EP (1) | EP1740094A4 (pt) |
JP (1) | JP2007530695A (pt) |
KR (1) | KR20060135922A (pt) |
AU (1) | AU2005231336A1 (pt) |
BR (1) | BRPI0509359A (pt) |
CA (1) | CA2561266A1 (pt) |
EA (1) | EA010834B1 (pt) |
IL (1) | IL178331A0 (pt) |
MX (1) | MXPA06011244A (pt) |
WO (1) | WO2005097123A2 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
KR20060135922A (ko) * | 2004-03-29 | 2006-12-29 | 이노텍 파마슈티컬스 코포레이션 | 피리딜 치환된 포르피린 화합물 및 이의 사용 방법 |
GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
US7642250B2 (en) * | 2005-09-28 | 2010-01-05 | Inotek Pharmaceuticals Corporation | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof |
CN101355876B (zh) | 2005-11-09 | 2012-09-05 | 康宾纳特克斯公司 | 一种适用于眼部给药的组合物 |
US20100120738A1 (en) * | 2006-09-11 | 2010-05-13 | Bernard Malfroy-Camine | Anti-apoptotic benzodiazepine receptor ligand inhibitors |
EP2056675B1 (en) | 2006-10-12 | 2019-01-09 | Galera Labs, LLC | Methods of treating oral mucositis |
KR20080047956A (ko) * | 2006-11-27 | 2008-05-30 | 주식회사 엠디바이오알파 | 발기부전의 치료 및 예방을 위한 약제 조성물 |
US8791099B2 (en) * | 2007-08-28 | 2014-07-29 | Technion Research And Development Foundation Ltd. | Transition metal complexes of corroles for preventing cardiovascular diseases or disorders |
KR101405823B1 (ko) * | 2007-12-24 | 2014-06-12 | 주식회사 케이티앤지생명과학 | 녹내장의 치료 및 예방을 위한 약제 조성물 |
KR20090071829A (ko) * | 2007-12-28 | 2009-07-02 | 주식회사 머젠스 | 신장질환의 치료 및 예방을 위한 약제 조성물 |
US20090257999A1 (en) * | 2007-12-31 | 2009-10-15 | Inotek Pharmaceuticals Corporation | Method of preventing contrast-induced nephropathy |
JP5669123B2 (ja) * | 2009-03-17 | 2015-02-12 | 国立大学法人 東京大学 | 発光によるビタミンc検出法及び定量法 |
JP4510929B1 (ja) * | 2009-04-09 | 2010-07-28 | パナソニック株式会社 | テロメラーゼ反応阻害方法およびそれに用いられるテロメラーゼ反応阻害剤 |
WO2010116423A1 (ja) * | 2009-04-09 | 2010-10-14 | パナソニック株式会社 | テロメラーゼ反応阻害方法 |
WO2012033916A1 (en) * | 2010-09-08 | 2012-03-15 | Southern Illinois University Edwardsville | Method for treating chronic pain |
EP2760874A4 (en) | 2011-09-26 | 2015-04-08 | Galera Therapeutics Llc | METHOD FOR THE TREATMENT OF ILLNESSES |
EP2911662A4 (en) * | 2012-10-25 | 2016-09-28 | Technion Res & Dev Foundation | METHOD OF TREATING A DISEASE |
US10188601B2 (en) * | 2013-09-22 | 2019-01-29 | Brenda Laster | Continuous long-term controlled release of telomerase inhibitors |
US9034596B1 (en) | 2014-04-17 | 2015-05-19 | Kuwait University | Method for fluorescent staining of cellular and intracellular membranes |
AU2019215032A1 (en) * | 2018-01-31 | 2020-09-10 | Board Of Regents Of The University Of Texas System | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4822899A (en) * | 1985-04-12 | 1989-04-18 | The University Of Michigan | Metallic porphyrin complexes as catalysts in epoxidation reactions |
US5990363A (en) * | 1987-01-02 | 1999-11-23 | Sun Company, Inc. | Method for oxidizing alkanes using novel porphyrins synthesized from dipyrromethanes and aldehydes |
US5227405A (en) * | 1987-03-31 | 1993-07-13 | Duke University | Superoxide dismutase mimic |
US5223538A (en) * | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
JPH0338587A (ja) | 1989-07-03 | 1991-02-19 | Doujin Kagaku Kenkyusho:Kk | 酸化反応を触媒する標識化合物 |
US6204259B1 (en) * | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US6127356A (en) * | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5747026A (en) | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
US5994339A (en) * | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
FR2717385B1 (fr) | 1994-03-21 | 1996-04-19 | Oreal | Composition cosmétique contenant en association une superoxyde dismutase et une porphyrine. |
US6245758B1 (en) * | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
WO1996009053A1 (en) * | 1994-09-20 | 1996-03-28 | Duke University | Oxidoreductase activity of manganic porphyrins |
US6013241A (en) * | 1995-01-23 | 2000-01-11 | Schering Aktiengesellschaft | Use of porphyrin-complex or expanded porphyrin-complex compounds as an infarction localization diagnosticum |
AU6031096A (en) | 1995-06-05 | 1996-12-24 | Duke University | Nitrosylated and nitrated superoxide oxidants and reductants |
ATE306936T1 (de) * | 1995-06-07 | 2005-11-15 | Univ Duke | Faenger fuer oxidantien |
US6002026A (en) * | 1996-07-26 | 1999-12-14 | The Trustees Of Princeton University | Catalytic oxygenation of hydrocarbons by metalloporphyrin and metallosalen complexes |
DE19647640A1 (de) | 1996-11-18 | 1998-05-20 | Basf Ag | Monoverbrückte Porphyrin-Dimere und deren Metallkomplexe, Verfahren zu deren Herstellung sowie katalytische Verfahren unter Verwendung der Metallporphyrinkomplexe |
US6087493A (en) * | 1997-02-05 | 2000-07-11 | Regents Of The University Of Texas System | Porphyrin compounds as telomerase inhibitors |
IL135949A0 (en) * | 1997-11-03 | 2001-05-20 | Univ Duke | Substituted porphyrins |
US6194566B1 (en) * | 1997-12-02 | 2001-02-27 | Schering Aktiengesellschaft | Process for the production of metalloporphyrin-metal complex conjugates |
WO1999055388A1 (en) | 1998-04-24 | 1999-11-04 | Duke University | Substituted porphyrins |
IL126953A0 (en) * | 1998-11-08 | 1999-09-22 | Yeda Res & Dev | Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives |
JP4501128B2 (ja) * | 1999-01-25 | 2010-07-14 | ナショナル ジュウィッシュ ヘルス | 置換ポルフィリン |
US6448239B1 (en) | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
AU1087401A (en) * | 1999-10-13 | 2001-04-23 | Uab Research Foundation | Metalloporphyrin treatment of neurologic disease |
US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
US6403788B1 (en) * | 2000-07-11 | 2002-06-11 | Eukarion, Inc. | Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species |
US6573258B2 (en) * | 2000-09-27 | 2003-06-03 | Frontier Scientific, Inc. | Photodynamic porphyrin antimicrobial agents |
WO2002098431A1 (en) * | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
GB0114155D0 (en) | 2001-06-11 | 2001-08-01 | Unilever Plc | Complex for catalytically bleaching a substrate |
US20030086916A1 (en) * | 2001-10-12 | 2003-05-08 | Goligorsky Michael S. | Use of peroxynitrite scavengers or peroxynitrite formation inhibitors that do not diminish nitric oxide synthesis or activity to reverse or prevent premature vascular senescence |
FR2837202B1 (fr) | 2002-03-15 | 2007-08-31 | Centre Nat Rech Scient | Nouveaux derives de porphyrines, leur procede de preparation compositions pharmaceutiques et utilisations |
CN100420689C (zh) * | 2002-04-08 | 2008-09-24 | 巩宪昌 | 带有大取代基的卟啉衍生物、其制备方法及其作为小分子抗氧化剂的应用 |
US6650137B2 (en) * | 2002-04-11 | 2003-11-18 | Daimlerchrysler Corporation | Circuit for monitoring an open collector output circuit with a significant offset |
EP1513537A4 (en) * | 2002-06-07 | 2006-09-06 | Univ Duke | SUBSTITUTED PORPHYRINS |
WO2005077269A1 (en) * | 2004-02-09 | 2005-08-25 | Duke University | Substituted porphyrins |
KR20060135922A (ko) * | 2004-03-29 | 2006-12-29 | 이노텍 파마슈티컬스 코포레이션 | 피리딜 치환된 포르피린 화합물 및 이의 사용 방법 |
US7642250B2 (en) * | 2005-09-28 | 2010-01-05 | Inotek Pharmaceuticals Corporation | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof |
JP5203214B2 (ja) | 2005-11-30 | 2013-06-05 | イノテック ファーマシューティカルズ コーポレイション | プリン化合物およびその使用方法 |
-
2005
- 2005-03-25 KR KR1020067022445A patent/KR20060135922A/ko not_active Application Discontinuation
- 2005-03-25 EP EP05732040A patent/EP1740094A4/en not_active Withdrawn
- 2005-03-25 CA CA002561266A patent/CA2561266A1/en not_active Abandoned
- 2005-03-25 AU AU2005231336A patent/AU2005231336A1/en not_active Abandoned
- 2005-03-25 JP JP2007506402A patent/JP2007530695A/ja active Pending
- 2005-03-25 MX MXPA06011244A patent/MXPA06011244A/es active IP Right Grant
- 2005-03-25 WO PCT/US2005/010167 patent/WO2005097123A2/en active Application Filing
- 2005-03-25 EA EA200601803A patent/EA010834B1/ru not_active IP Right Cessation
- 2005-03-25 BR BRPI0509359-7A patent/BRPI0509359A/pt not_active IP Right Cessation
- 2005-03-25 US US11/090,447 patent/US7432369B2/en not_active Expired - Fee Related
-
2006
- 2006-09-27 IL IL178331A patent/IL178331A0/en unknown
-
2007
- 2007-07-19 US US11/880,068 patent/US20080009473A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2007530695A (ja) | 2007-11-01 |
EA010834B1 (ru) | 2008-12-30 |
EP1740094A2 (en) | 2007-01-10 |
MXPA06011244A (es) | 2007-04-13 |
AU2005231336A1 (en) | 2005-10-20 |
IL178331A0 (en) | 2007-02-11 |
CA2561266A1 (en) | 2005-10-20 |
EA200601803A1 (ru) | 2007-10-26 |
WO2005097123A2 (en) | 2005-10-20 |
US7432369B2 (en) | 2008-10-07 |
US20080009473A1 (en) | 2008-01-10 |
WO2005097123A3 (en) | 2005-12-22 |
EP1740094A4 (en) | 2008-09-03 |
KR20060135922A (ko) | 2006-12-29 |
US20060003982A1 (en) | 2006-01-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0509359A (pt) | compostos de porfirina substituìda por piridila e métodos de empregos destes | |
WO2007038630A3 (en) | N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof | |
BRPI0607240A2 (pt) | derivados de maleimida, composições farmacêuticas e métodos para tratamento de cáncer | |
BRPI0508233A (pt) | derivados de isoquinolina e métodos para emprego destes | |
JP2009538897A5 (pt) | ||
SMT201300096B (it) | Inibitori di prolil idrossilasi | |
JP2008535902A5 (pt) | ||
EA200600689A1 (ru) | Замещённые бензазолы и их применение в качестве ингибиторов raf киназы | |
JP2008535903A5 (pt) | ||
ATE551060T1 (de) | Zusammensetzungen und verfahren zur behandlung von neovaskulären erkrankungen | |
HK1145839A1 (en) | N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors | |
EA200602197A1 (ru) | Пуриновые производные в качестве агонистов аденозиновых арецепторов и способы их применения | |
ECSP10010589A (es) | Farmaco contra el cancer de higado | |
ATE531377T1 (de) | Purin-derivate und anwendungsverfahren | |
AR057295A1 (es) | Combinaciones y procedimientos para usar un compuestos de indolinona | |
MY143568A (en) | 11b-hsd1 inhibitors for the treatment of diabetes | |
AR069244A1 (es) | Metodos para administrar n-( 5- ter- butil- isoxixasol-3-il) -n'- (4(7-(2- morfolin-4-il- etoxi) imidazo (2,1-b) (1,3) benzotiazol -2-il) fenil) urea para tratar una enfermedad proliferante y composicion farmaceutica | |
NO20074737L (no) | Isokinolinforbindelser og fremgangsmater for anvendelse derav | |
JP2009510165A5 (pt) | ||
BRPI0508052A (pt) | derivados de lactamo tetracìclico e seus usos | |
RU2011150250A (ru) | Антагонисты пути hedgehog и их терапевтическое применение | |
BRPI0606191A2 (pt) | compostos de amino e carboxamido tetracìclicos e métodos do seu uso | |
ATE419249T1 (de) | Inhibitoren von mitotischem kinesin | |
AR048573A1 (es) | Compuesto de 8-azoniabiciclo[3.2.1]octano sustituido en la posicion 3, composicion farmceutica que lo comprende y su uso para preparar esta ultima | |
AR054888A1 (es) | Derivados de quinolina como agentes antibacterianos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |